Monkeypox infection: The past, present, and futureReview Published on 2022-12-012023-06-09 Journal: International immunopharmacology [Category] Fulltext, 원숭이두창, [키워드] Etiopathology Infection Monkeypox prevention therapeutic targets Vaccines. [DOI] 10.1016/j.intimp.2022.109382 PMC 바로가기 [Article Type] Review
Galectin-3 binding protein stimulated IL-6 expression is impeded by antibody intervention in SARS-CoV-2 susceptible cell linesArticle Published on 2022-10-112022-11-15 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 진단, [키워드] Activation affected antibody binding cell line cell types Colon contribute COVID-19 COVID-19 patients described disease epithelial expression galectin-3 global pandemic identify IL-6 IL-6 expression inflammatory cells Intervention lung epithelial marker monoclonal antibody pathophysiology pro-inflammatory cytokine Protein receptor Research SARS-CoV-2 severe cases severe COVID-19 patients severe disease severity stimulate stimulated susceptible cell the cytokine storm therapeutic targets Treatment was reduced [DOI] 10.1038/s41598-022-20852-x PMC 바로가기
Increased percentage of apoptotic and CTLA-4 (CD152) expressing cells in CD4+/CD8+ cells in COVID-19 patientsArticle Published on 2022-09-232022-11-15 Journal: Medicine [Category] 바이오마커, 치료제, [키워드] addition analyzed Apoptosis apoptotic apoptotic cell association blood cell C-reactive protein can be used CD4+ cell CD8+ cell Cell cell count cells characterized Chest CT Clinical severity confirmed case correlated correlation COVID-19 COVID-19 case COVID-19 patient COVID-19 patients CRP CTLA-4 cytotoxic T-lymphocyte antigen-4 detect Diagnosis diagnostic Dyspnea eosinophil expressing expression ferritin flow cytometry healthy control healthy volunteer In-patients Increased Infectious disease lymphocyte Lymphocyte count lymphopenia neutrophil Patient patients Platelet proportion reduced severity significant difference significantly therapeutic targets Total up-regulated WBCs while white with COVID-19 [DOI] 10.1097/MD.0000000000030650 PMC 바로가기
Preclinical findings: The pharmacological targets and molecular mechanisms of ferulic acid treatment for COVID-19 and osteosarcoma via targeting autophagyArticle Published on 2022-09-202022-11-15 Journal: Frontiers in Endocrinology [Category] SARS, 변종, 유전자 메커니즘, 진단, [키워드] 2019 coronavirus disease activities acute respiratory disease applied autophagy Bioinformatics analysis characterized clinical coronavirus COVID-19 deficiency determine develop Effectiveness Evidence ferulic acid Genes impacted individuals MAPK1 mechanism mechanisms medication methodology molecular docking molecular docking analysis molecular mechanism network pharmacology number of infected Ontology osteosarcoma pandemic pathway enrichment Patient Patients with cancer pharmacological pharmacological target PIK3R1 Population potential therapeutic target Preclinical Protein regulatory subunit SARS-CoV-2 STAT3 target targets therapeutic therapeutic targets therapeutic targets. Transcription treat treatment for COVID-19 variant [DOI] 10.3389/fendo.2022.971687 PMC 바로가기
Multiomics approach reveals the ubiquitination-specific processes hijacked by SARS-CoV-2Article Published on 2022-09-072022-11-15 Journal: Signal Transduction and Targeted Therapy [Category] SARS, 유전자 메커니즘, 치료제, [키워드] activated addition Analysis Anti-inflammation Antiviral antiviral drug approach caused conducted coronavirus 2 COVID-19 disrupting E3 ligase E3 ubiquitin ligase effective ENhance enzyme global pandemic Health highlighting Host Infection Inflammatory responses innate immune response Innate immunity interferon lung epithelial cell Lung epithelial cells mechanism modulate multiomics pathogenesis of SARS-CoV-2 promote Protein proteomic respiratory reveal SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 protein significantly Spread targets the epidemic the Spike therapeutic targets transcriptomic Vaccine viral infection [DOI] 10.1038/s41392-022-01156-y PMC 바로가기
Role of the PD-1 and PD-L1 axis in COVID-19COVID-19에서 PD-1 및 PD-L1 축의 역할Editorial Published on 2022-09-012022-09-11 Journal: Future Microbiology [Category] 바이오마커, [키워드] Abstract adaptive adaptive immune cells COVID-19 COVID-19 patient dysregulated expression immune immune cells immune checkpoint molecules Innate immune cells innate immune cells. Ligand PD-1 PD-L1 Prognostic marker Prognostic markers role SARS-CoV-2 Severe case severe cases therapeutic target therapeutic targets [DOI] 10.2217/fmb-2022-0103 PMC 바로가기 [Article Type] Editorial
Differential gene expression profiling reveals potential biomarkers and pharmacological compounds against SARS-CoV-2: Insights from machine learning and bioinformatics approachesArticle Published on 2022-08-172022-11-15 Journal: Frontiers in Immunology [Category] SARS, 바이오마커, 치료기술, 치료제, [키워드] acid approach bioinformatics caused Comorbidities complex interplay Compound contribute coronavirus 2 COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients COVID-19 progression Critical cyclosporine DEGs detect develop differentially expressed gene disease disease pathogenesis dysregulated E2F1 effort EGR1 expressed Factor functional functional enrichment Gene expression profiling Gene regulatory networks Genetic Genomics healthy controls healthy individual humans identify indicated individual individuals insight inter-individual Interaction machine learning approach MAX Mental mental retardation miRNA expression miRNAs nasopharyngeal network analysis offer Ontology overexpressed pandemic pathophysiology pathway pharmacological Potential biomarker Regulatory respiratory responsible reveal RNA-Seq RNA-seq data SARS-CoV-2 SARS-COV-2 infection Spread SRF TFS the SARS-CoV-2 therapeutic option therapeutic target therapeutic targets therapeutic targets. Vaccine Variability with COVID-19 YY1 [DOI] 10.3389/fimmu.2022.918692 PMC 바로가기
A validated LC-MS/MS method for determination of antiviral prodrug molnupiravir in human plasma and its application for a pharmacokinetic modeling study in healthy Egyptian volunteers인간 혈장에서 항 바이러스 전구 약물 Molnupiravir의 결정을위한 검증 된 LC-MS/MS 방법 및 건강한 이집트 자원 봉사자들의 약동학 적 모델링 연구에 대한 적용Article Published on 2022-08-152022-08-31 Journal: Journal of chromatography. B, Analytical technolog [Category] COVID19(2023년), MERS, SARS, 치료기술, 치료제, [키워드] acetic acetic acid acetonitrile Agilent analyte analyzed Antiviral approach AUC C max Concentration confidence interval detection determine develop dosage dose Eclipse Efficacy ESI evaluate extraction FDA flow rate geometric mean geometric mean ratios Geometric means GMR Guidance healthy healthy volunteer healthy volunteers Human plasma LC-MS/MS Linear regression linearity m/z mass spectrometer mass spectrometry maximum concentration metabolite mixture molnupiravir N-hydroxycytidine NHC pharmacokinetic pharmacokinetic data plasma Population Population Pharmacokinetic Modeling positive protein precipitation pumped recommendation required ribavirin SARS-CoV-2 SARS-CoV-2. Simulation solvent subjects therapeutic target therapeutic targets Treatment triple quadrupole mass spectrometer United State United States Volunteer was performed was used were used [DOI] 10.1016/j.jchromb.2022.123363 PMC 바로가기 [Article Type] Article
Possible Role of Matrix Metalloproteinases and TGF-β in COVID-19 Severity and SequelaeCOVID-19 중증도 및 후유증에서 기질 금속단백분해효소 및 TGF-β의 가능한 역할Review Published on 2022-08-012022-09-11 Journal: Journal of interferon & cytokine research : the of [Category] COVID19(2023년), SARS, 바이오마커, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 analyzed Antiviral agents ARDS available data Biomarker Biomarkers Clinical features clinical form complex interplay convalescence convalescent COVID-19 patients coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 COVID-19 pathogenesis cytokine Cytokines death Diagnosis ECM elicited exacerbated Extracellular matrix Factor fibrosis growth hallmark immune response immune responses Immunity immunological implication Infection Inflammation knowledge Lungs mandatory Manifestations matrix matrix metalloproteinase matrix metalloproteinases MMPs molecular other respiratory infection other respiratory infections paradox Participation pathobiology of COVID-19 Prognosis provide pulmonary fibrosis pulmonary fibrosis. reduce remark required Research respiratory respiratory infections role SARS-CoV-2 sequela serological Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 severe COVID-19 TGF-β the disease therapeutic target therapeutic targets therapy tissue injury transforming growth factor Treatment wound healing [DOI] 10.1089/jir.2021.0222 PMC 바로가기 [Article Type] Review
Host genomics of SARS-CoV-2 infectionSARS-CoV-2 감염의 숙주 유전체학Review Published on 2022-08-012022-09-11 Journal: European Journal of Human Genetics [Category] COVID19(2023년), SARS, 바이오마커, 변종, 신약개발, 유전자 메커니즘, 치료제, [키워드] acute infection approach approaches association Asymptomatic causal variant complications COVID-19 COVID-19 pneumonia demographic disease disease severity downstream Exome explain exploration Factor fraction functional genetic determinant genetic determinants Genetic variant Genome sequencing Genome-wide association studies genomic study highlighting host-virus interactions Human human genetic variation immune function individuals International involved life-threatening locus management Mild outcome pandemic Pathogenesis pathway Pathways Pneumonia Region required SARS-CoV-2 SARS-CoV-2 infected individuals SARS-COV-2 infection SARS-CoV-2 pathogenesis severe cases shown therapeutic targets type I interferon type I interferon response Variability with COVID-19 [DOI] 10.1038/s41431-022-01136-4 PMC 바로가기 [Article Type] Review