Has the human biological interaction with SARS ‐ CoV2 variants entered a pliant “Faustian bargain”?Commentary Published on 2024-07-092024-09-05 Journal: Pharmacology Research & Perspectives [Category] update2024, [키워드] COVID‐19 Gibbs free energy Thermodynamics [DOI] 10.1002/prp2.1244 PMC 바로가기 [Article Type] Commentary
Calorimetric analysis of AdcR and its interactions with zinc(II) and DNAarticle Published on 2023-10-312024-09-01 Journal: Journal of Inorganic Biochemistry [Category] 폐렴구균 감염증, [키워드] differential scanning calorimetry enthalpy metal binding Thermodynamics transcription factor [Article Type] article
Systems analysis shows that thermodynamic physiological and pharmacological fundamentals drive COVID‐19 and response to treatmentReview Published on 2022-02-012023-06-14 Journal: Pharmacology Research & Perspectives [Category] COVID19(2023년), MERS, SARS, [키워드] ACE2 affinity complex systems COVID‐19 Dissociation constant Gibbs free energy Innate immunity Kinetics law of mass action MERS pandemic Pharmacology Physiology renin angiotensin system SARS‐CoV‐1 SARS‐CoV‐2 Thermodynamics tropism variants virus [DOI] 10.1002/prp2.922 PMC 바로가기 [Article Type] Review
On the use of aggregated human mobility data to estimate the reproduction numberArticle Published on 2021-12-022022-10-29 Journal: Scientific Reports [Category] COVID-19, SARS, [키워드] average changes in Contact described disease epidemiological estimate Evolution explain Google Infectious disease lockdown lockdown policies mitigate Mobility network predict reduce reduction Reproduction number risk SARS-CoV-2 Statistical physics Thermodynamics variables viral infection [DOI] 10.1038/s41598-021-02760-8 PMC 바로가기 [Article Type] Article
Dynamics prediction of emerging notable spike protein mutations in SARS-CoV-2 implies a need for updated vaccinesSARS-CoV-2에서 떠오르는 주목할만한 스파이크 단백질 돌연변이의 역학 예측은 업데이트된 백신의 필요성을 의미합니다Article Published on 2021-12-012022-09-11 Journal: Biochimie [Category] SARS, 변종, 진단, [키워드] addition Alpha antigenicity B.1.1.7 B.1.351 B.1.617.2 Beta binding cause clade cleavage conformational change COVID-19 D614G Delta dominant variant Dynamics Efficacy exhibited flexibility furin furin cleavage Gamma human cell include lack molecular molecular dynamics Mutation mutation D614G neutralization Nextstrain notable other variant other variants P.1 pathogenicity polybasic predict previous study Protein question RBD Receptor-binding domain SARS-CoV-2 spike Spike protein stability structural biology Structure Superimposition the antibody the receptor-binding domain the spike protein Thermodynamics Vaccine Vaccines variant variants virus wild type Wuhan [DOI] 10.1016/j.biochi.2021.08.011 PMC 바로가기 [Article Type] Article
Methodological notes on pandemic virus SARS-CoV-2 research대유행 바이러스 SARS-CoV-2 연구에 대한 방법론적 참고사항Article Published on 2021-10-012022-09-11 Journal: Theory in biosciences = Theorie in den Biowissensc [Category] SARS, 변종, [키워드] affected Bacteria can not cell entry China complexes correlation country COVID-19 COVID-19 pandemic dust Environment explain Formulation Health Infection Italy mathematical methodological molecular Nanoparticles New coronavirus new coronavirus SARS-CoV-2 pandemic virus Particulate Particulate matter Pathways pollen Pollution Population predict Prophylaxis SARS-CoV-2 SARS-CoV-2 coronavirus SARS-CoV-2 research species spike Spike proteins spikes spores Spread systematic error the spike protein Thermodynamics Thermodynamics. threshold viral particle viral variant viruses [DOI] 10.1007/s12064-021-00355-5 PMC 바로가기 [Article Type] Article
D614G mutation in the SARS-CoV-2 spike protein enhances viral fitness by desensitizing it to temperature-dependent denaturationAccelerated Communication Published on 2021-09-242022-10-30 Journal: The Journal of Biological Chemistry [Category] COVID-19, MERS, SARS, [키워드] 3DVA, three-dimensional variability analysis ACE2, angiotensin converting enzyme 2 Alter approach binding Characteristics cold-induced unfolding conformational conjugate COVID-19 pandemic Cryo-electron microscopy CTF, contrast transfer function D614G D614G mutation demonstrated denaturation differential scanning fluorimetry dominant DSC, differential scanning calorimetry DSF, differential scanning fluorimetry ENhance exceptional exhibited host receptor mechanism Microscopy molecular basis Multiple Mutation NSEM, negative staining electron microscopy analysis physiological protein stability RBD, receptor-binding domain RBDs RBM, receptor-binding motif Receptor-binding domain SARS-CoV-2 SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 significantly Spike protein stability staining the SARS-CoV-2 the spike protein thermal stability Thermodynamics Vaccine development variant viral fitness Viral protein virus WT, wild type [DOI] 10.1016/j.jbc.2021.101238 PMC 바로가기 [Article Type] Accelerated Communication
Possible effects of air temperature on COVID‐19 disease severity and transmission ratesResearch Article Published on 2021-05-032022-11-01 Journal: Journal of medical virology [Category] COVID-19, SARS, [키워드] acute respiratory syndrome Air temperature airway available data body temperature contribute core body temperature coronavirus coronavirus disease Course COVID‐19 COVID‐19 decrease disease severity Effect in vitro increase increase in Increased Infection initiate lower airway occur outcomes progression of disease promote prophylactic treatment reductions in Replication SARS‐CoV‐2 severe disease stability Support temperature the disease Thermodynamics Transmission transmission rate upper airway viral growth viral titer Virology [DOI] 10.1002/jmv.27042 PMC 바로가기 [Article Type] Research Article
The dimer-monomer equilibrium of SARS-CoV-2 main protease is affected by small molecule inhibitorsSARS-CoV-2 주요 프로테아제의 이량체-단량체 평형은 소분자 억제제에 의해 영향을 받습니다Article Published on 2021-04-292022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 유전자 메커니즘, 치료제, [키워드] Affect affected angle antiviral drug Biophysics cleave Computational biology and bioinformatics coronavirus coronavirus SARS-CoV-2 COVID-19 pandemic Dissociation constant Drug discovery enzymatic activity etiological agent feature functional homodimer information inhibitor knowledge leads M pro maturation Molecular biology molecular mechanism opposite polyproteins protease protein concentration residue SARS-CoV-2 SARS-CoV-2 main protease selected small molecule small molecule inhibitor Small molecules solution temperature therapeutic intervention thermodynamic Thermodynamics Virtual screening X-ray [DOI] 10.1038/s41598-021-88630-9 PMC 바로가기 [Article Type] Article
Tuning Proton Transfer Thermodynamics in SARS-CoV-2 Main Protease: Implications for Catalysis and Inhibitor DesignLetter Published on 2021-04-262022-10-31 Journal: The journal of physical chemistry letters [Category] COVID-19, MERS, SARS, [키워드] activated Activation approach catalysis catalytic complex covalent binding Cys145 desolvation ENhance enzyme feasibility His41 identify inhibitor inhibitors proton reduce reduction Region required SARS-CoV-2 SARS-CoV-2 main protease selective significantly thermodynamic Thermodynamics transfer tuning water molecules [DOI] 10.1021/acs.jpclett.1c00425 PMC 바로가기 [Article Type] Letter