An engineered 5-helix bundle derived from SARS-CoV-2 S2 pre-binds sarbecoviral spike at both serological- and endosomal-pH to inhibit virus entrySARS-CoV-2 S2에서 파생된 조작된 5나선 번들은 바이러스 진입을 억제하기 위해 혈청학적 pH와 엔도솜 pH 모두에서 사베코바이러스 스파이크를 사전 결합합니다.Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, [키워드] 5-helix bundle (5HB) acute respiratory syndrome acute respiratory syndrome coronavirus bind binding Broad-spectrum inhibition can not cell membrane construction coronavirus Evidence feature fusion heptad repeat highlighting host cell host cells IC50 infections inhibit neutralize peptide peptides pre-fusion predominant Protein sarbecovirus Sarbecoviruses SARS-CoV-2 SARS-CoV-2 pseudovirus SARS-CoV-2 S2 SARS-CoV-2 variant SARS-CoV-2 variants serological severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 structural basis These data Treatment viral entry viral spike virus entry virus infection [DOI] 10.1080/22221751.2022.2095308 PMC 바로가기 [Article Type] Article
Analysis of ACE2 and TMPRSS2 coding variants as a risk factor for SARS-CoV-2 from 946 whole-exome sequencing data in the Turkish populationArticle Published on 2022-11-012022-11-16 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] ACE2 ACE2 variant allele frequency Analysis analyzed calculated coding coding variant Cohort conducted contribute COVID-19 database defined filtered Frequency functional Genetic Genome host cell increase infected patient Intronic lack majority National nonsynonymous variant Population populations Protective retrospective risk factor SARS-CoV-2 SARS-COV-2 infection susceptibility Symptom These data TMPRSS2 variant variants Variation whole-exome sequencing with COVID-19 [DOI] 10.1002/jmv.27976 PMC 바로가기
Aerosolized Hydrogen Peroxide Decontamination of N95 Respirators, with Fit-Testing and Viral Inactivation, Demonstrates Feasibility for Reuse during the COVID-19 PandemicArticle Published on 2022-10-262022-11-15 Journal: mSphere [Category] COVID19(2023년), SARS, 진단, [키워드] absorbed acute respiratory syndrome aerosolized hydrogen peroxide Aerosols Bacterial baseline Biosafety Level 3 BSL3 Care Clinical use comparable coronavirus COVID-19 COVID-19 pandemic coxsackievirus Critical CURIS decontamination develop Disinfection effective Efficiency evaluated experimental validation External filtering facepiece (FFP) respirators (FFR) filtration fit-testing greater Health Health care worker herpes simplex HSV-1 hydrogen hydrogen peroxide inactivation include indicated limit limitation Multiple N95 respirator N95 respirators occupational pandemic pathogen peroxide Personal protective equipment Protective provided Quantitative Research Respirator respirators respiratory droplet Result reuse Safe Safety SARS-CoV-2 SARS-CoV2 spores Sterilization These data transmitted Treatment viral inactivation virologic testing virus while [DOI] 10.1128/msphere.00303-22 PMC 바로가기
Time Series Analysis of SARS-CoV-2 Genomes and Correlations among Highly Prevalent MutationsArticle Published on 2022-10-262022-11-16 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome Analysis arising caused characterized Cluster Clustering computational tool contribute coronavirus correlated correlation correlation coefficient COVID-19 Deleterious Effect effort Evolution Frequency Genome genomes Hierarchical hierarchical clustering identify imperative in viral Meta-analysis Mutation mutations negative correlation Neutral NSP2 Nsp3 nucleotide ORF3a protein P323L pandemic Pearson Pearson correlation performed positive Protein protein dynamics. Q57H RdRP replaced RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 genome SARS-CoV-2 genomic sequence SARS-CoV-2 isolate SARS-CoV-2 sequences Scientific community Sery shown similarity stabilizing effect statistical T85I These data time UTR viral evolution viral genomes viral pathogenesis viral replication viral strains wild type wild-type [DOI] 10.1128/spectrum.01219-22 PMC 바로가기
Computational Design and Experimental Validation of ACE2-Derived Peptides as SARS-CoV-2 Receptor Binding Domain InhibitorsArticle Published on 2022-10-202022-11-16 Journal: The journal of physical chemistry. B [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 binding Algorithm Alpha variant bind binding binding affinity candidate caused Concentration concentrations COVID-19 pandemic demonstrated disrupt domain ELISA assays entry of SARS-CoV-2 experiments expressed globe host cells human cells inhibitory initial insoluble Interaction moderate Molecular dynamics simulation molecule peptidase peptide Prevent Protein RBD SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2-RBD sequence spike the RBD the SARS-CoV-2 therapeutic These data validation variants virus entry was used Wuhan-Hu-1 α1 helix [DOI] 10.1021/acs.jpcb.2c03918 PMC 바로가기
Pre-existing humoral immunity to low pathogenic human coronaviruses exhibits limited cross-reactive antibodies response against SARS-CoV-2 in childrenArticle Published on 2022-10-192022-11-15 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, [키워드] acute respiratory syndrome analyzed anti-S IgG antibody Antigen antigen specific antibody Asymptomatic cause children collected coronavirus cross-react cross-reactive cross-reactive antibody exhibit HCoV-OC43 Hospitalization Humoral immunity IgG antibody Infection low pathogenic human coronaviruses median age mild symptoms Mutant SARS-CoV-2 Neutralizing activity neutralizing antibody nucleocapsid occurred outbreak pathogenic pathogenic human coronavirus question Re-infection reached Receptor binding domain SARS-CoV-2 seropositive sample serum sample Seven SRAS-CoV-2 These data wild-type [DOI] 10.3389/fimmu.2022.1042406 PMC 바로가기
Interpreting global variations in the toll of COVID-19: The case for context and nuance in hypothesis generation and testingArticle Published on 2022-10-192022-11-16 Journal: Frontiers in Public Health [Category] COVID19(2023년), SARS, 변종, [키워드] affecting aggregate aggregates Analysis analyzed benefit Biomarker Biomarkers cause-specific mortality country covariate COVID COVID-19 COVID-19 pandemic database domain domains driver ecological events extension Factor Factors flexible Health health economics Health policy Hypothesis Interaction interactions Interpreting Isolation joint Lifestyle factors machine learning morbidity National obesity OLS omicron outcome outcomes pandemic Policy Population populations potential risk response SARS-CoV-2 socioeconomics statistical statistical methods. These data variant variants Variation while [DOI] 10.3389/fpubh.2022.1010011 PMC 바로가기
Learning from the COVID-19 pandemic for future epidemics and pandemics preparedness and response in Guinea: Findings from a scoping reviewArticle Published on 2022-10-172022-11-16 Journal: Frontiers in Public Health [Category] COVID19(2023년), SARS, 변종, [키워드] activities Analysis anticipated applied boost conducted counterproductive country COVID-19 COVID-19 pandemic database distress Epidemic Epidemics epidemiological finding FIVE generate globe Guinea health system health system preparedness and response implementation IMPROVE information learning measure Measures mechanism media National Novel coronavirus outbreak pandemic Pandemics policy decisions provide Research Resilience responses SARS-CoV-2 These data triggered vaccination variant [DOI] 10.3389/fpubh.2022.879850 PMC 바로가기
[Adherence to influenza vaccination campaign 2020/21 in the pandemic SARS-CoV-2. Context analysis in management changes: A pilot study]Article Published on 2022-10-012022-11-16 Journal: Semergen [Category] COVID19(2023년), SARS, 치료기술, [키워드] Administered Analysis anti-vaccine Antivacunas applied Campaña de vacunación carried Cobertura vacunal Context Coverage dose English Estrategias de implementación vacunal evaluate evaluated extension favor Final Gripe Health implementation Influenza Influenza virus introduced management material Pandemia pandemic Patient patients older SARS-CoV-2 SARS-CoV-2 pandemic shown significant difference Spanish Support These data vaccination Vaccination campaign vaccination coverage Vaccine Vaccine implementation strategies. zone [DOI] 10.1016/j.semerg.2022.03.012 PMC 바로가기
Projection in genomic analysis: A theoretical basis to rationalize tensor decomposition and principal component analysis as feature selection toolsArticle Published on 2022-09-292022-11-16 Journal: PLoS ONE [Category] 유전자 메커니즘, [키워드] addition adjusted applied Biomarker Cancer Cluster Conventional COVID-19 Critical data set data sets described differentially expressed gene distribution Drug discovery gaussian distribution Genes genomic identifying kidney null hypothesis P-value PCA principal component analysis projection pursuit Sample size statistical statistical test Tensor These data threshold treated vector [DOI] 10.1371/journal.pone.0275472 PMC 바로가기