thrombi – Communicable Diseases Research

Evidence of SARS-CoV-2 spike protein on retrieved thrombi from COVID-19 patients

COVID-19 환자로부터 회수된 혈전에서 SARS-CoV-2 스파이크 단백질의 증거

Article

Published on 2022-08-162022-09-11
Journal: Journal of Hematology & Oncology [Category] SARS, 치료기술, 치료법,

Platelets in the NETworks interweaving inflammation and thrombosis

염증과 혈전을 뒤섞는 NETworks의 혈소판

Review

Published on 2022-08-012022-09-11
Journal: Frontiers in Immunology [Category] 치료기술, 치료제,

[키워드] activate Bacterial Capillaries capillary characterized chemokine chemokines chromatin Clinical outcome Coagulation factors contribute contributing to Course COVID-19 COVID-19 pandemic COVID-19 patient Cytokine storm disease DNA engage ENhance Evidence expression Extracellular extracellular space Growth factors hemorrhage Hemostasis histone Histones host innate immunity immune response immunothrombosis IMPROVE increased mortality induce infiltration Inflammation Inflammatory diseases inflammatory signaling Interaction interface kill lesion lung majority mechanism microthrombi molecular mechanism NET NETs neutrophil neutrophil activation Neutrophil extracellular trap Neutrophil extracellular traps neutrophil infiltration Neutrophils other tissue other tissues pathogen Pathogens Pathways Patient Pattern recognition Pattern recognition receptors Platelet Platelets procoagulant Protein Proteins provide provided resulting signaling pathway subsequent surface expression survival target thrombi thrombosis thrombotic TLR2 TLR4 Topic TRAP Treatment vascular beds virus
[DOI] 10.3389/fimmu.2022.953129 PMC 바로가기 [Article Type] Review

Platelet activation and partial desensitization are associated with viral xenophagy in patients with severe COVID-19

혈소판 활성화 및 부분 탈감작은 중증 COVID-19 환자의 바이러스 이종과 관련이 있습니다

Article

Published on 2022-07-122022-09-11
Journal: Blood advances [Category] COVID19(2023년), SARS, 치료법,

[키워드] activated Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 aggregation Alter assays autophagy Bacterial sepsis changes in Combination Complication coronavirus Critically ill critically ill patients Cytokines decrease develop exhibited flow cytometry fraction Gene Expression GPVI healthy healthy donor healthy donors immunofluorescence indicated infected patient infected patients intensive care intensive care unit interactions intracellular vesicle investigated labeling leukocyte Localization lung marker mass spectrometry Microscopy Nucleocapsid proteins parameter Patient patients with COVID-19 plasma Platelet platelet activation platelet aggregation platelet-rich thrombi Platelets Proinflammatory cytokine proinflammatory cytokines prospective cohort Protein reduction SARS-CoV-2 SARS-CoV-2 particle SARS-CoV-2 particles secretion selective Sepsis severe acute respiratory syndrome Coronavirus severe COVID-19 shown spike Stimulation Structure Tandem mass spectrometry These data thrombi thrombocytopenia transmission electron microscopy Xenophagy
[DOI] 10.1182/bloodadvances.2022007143 PMC 바로가기 [Article Type] Article

Cerebral Venous Sinus Thrombosis following COVID-19 Vaccination: Analysis of 552 Worldwide Cases

Review

Published on 2022-02-032022-10-28
Journal: Vaccines [Category] COVID-19,

Complement Activation via the Lectin and Alternative Pathway in Patients With Severe COVID-19

중증 COVID-19 환자의 렉틴 및 대체 경로를 통한 보완 활성화

Immunology

Published on 2022-02-022022-09-11
Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술,

[키워드] activate activated Activation Acute kidney injury acute respiratory syndrome addition Alternative pathway alveolar alveolar septa analyzed Autopsy both groups both lungs C1q C3c C5b-9 causes cerebral hemorrhage CFD characterized collateral tissue complement Complement activation complement deposition Control correlated correlation COVID-19 COVID-19 patient COVID-19 patients Critically ill Critically ill patient critically ill patients Cytokines Defense deposit deposition deregulated died edema Factor followed by hyaline membrane hyaline membranes Immune cell immune cells immune system immunohistochemistry in both groups indicated Inflammatory response Injury investigated involved kidney kidneys lectin lectin pathway Local lung Lung injury Lungs MASP-2 membranes Mortality MPO myeloperoxidase neutrophil Neutrophils occurred Pathogens Patient patients with COVID-19 peritubular capillaries peritubular capillary positive Prevent pro-inflammatory cytokines Pulmonary embolism respiratory SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 virus SARS-CoV-2 virus particle SARS-CoV-2 virus particles semi-quantitative Severe acute respiratory syndrome severe COVID-19 SIGN significantly significantly higher significantly more Spike protein subsequent thrombi tissue damage tissue injury Treatment with COVID-19 worsening
[DOI] 10.3389/fimmu.2022.835156 PMC 바로가기 [Article Type] Immunology

Neutrophils predominate the immune signature of cerebral thrombi in COVID-19 stroke patients

호중구는 Covid-19 뇌졸중 환자에서 뇌 혈전의 면역 시그니처를 우세합니다.

Multicenter Study

Published on 2022-02-012022-09-10
Journal: Acta Neuropathologica Communications [Category] COVID19(2023년), Fulltext, MERS, SARS, 진단, 치료기술,

[키워드] ACE2 expression cells Chain Reaction characterized complement complex conducted Control control patients controls coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients docking Endovascular treatment Evidence expressed expression level Factor Features FIBRIN immune signature increased risk infected with COVID-19 Ischemic Stroke large vessel lymphocyte macrophages molecular Monocytes monocytes/macrophage monocytes/macrophages mortality rates MPO NETs neutrophil Neutrophil extracellular trap Neutrophil extracellular traps Neutrophils pathological analysis Patient patients Platelet Platelets polymerase chain polymerase chain reaction Ratio receptor ACE2 red blood cells retrieved ROC analysis SARS-CoV-2 SARS-CoV2 Sequencing severity stroke supplementary material the SARS-CoV-2 thrombi thrombosis thrombotic Thrombotic events Thrombus von Willebrand factor
[DOI] 10.1186/s40478-022-01313-y PMC 바로가기 [Article Type] Multicenter Study

Eculizumab in patients with severe coronavirus disease 2019 (COVID-19) requiring continuous positive airway pressure ventilator support: Retrospective cohort study

지속적인 양압 인공호흡기 지원이 필요한 중증 코로나바이러스 질환 2019(COVID-19) 환자의 에쿨리주맙: 후향적 코호트 연구

Observational Study

Published on 2021-12-202022-09-12
Journal: PLoS ONE [Category] Coronavirus, MERS, 임상, 진단,

[키워드] 95% CI age baseline baseline characteristics blockade change changes in Characteristics cohort study Complement activation Complication complications confirmation contribute Control controls coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 patient CPAP creatinine discharge discharged disease dose dysfunction eculizumab Endpoint Ex vivo finding IMPROVE IQR limitation lung dysfunction median Mortality outcome over Patient patients patients died positive airway pressure pressure Primary outcome Randomised controlled trials receiving respiratory rate Result SC5b-9 secondary Secondary outcomes serum creatinine severe coronavirus disease severe COVID-19 Sex significantly small sample size Standard therapy Support thrombi ventilator
[DOI] 10.1371/journal.pone.0261113 PMC 바로가기 [Article Type] Observational Study

Histopathological Evaluation of Deceased Persons in Lusaka, Zambia With or Without Coronavirus Disease 2019 (COVID-19) Infection: Results Obtained From Minimally Invasive Tissue Sampling

코로나바이러스 감염증 2019(COVID-19) 감염 여부에 관계없이 잠비아 루사카에서 사망한 사람의 조직병리학적 평가: 최소 침습적 조직 샘플링에서 얻은 결과

Supplement Articles

Published on 2021-12-152022-09-10
Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 치료기술,

[키워드] 48 hour 48 hours abnormality Acute kidney injury age AIDS alveolar damage Analysis Autopsy Chain Reaction collected Community coronavirus disease Coronavirus disease 2019 country COVID-19 cycle threshold death Deceased diabete diabetes Diagnosis died diffuse Diffuse alveolar damage eligible enrolled hepatic steatosis Human Human immunodeficiency virus immunodeficiency virus individual individuals infections information interstitial invasive kidney kidneys limitation liver lung lung abnormalities male median age minimally invasive tissue sampling Morgue MOST Nasopharyngeal swab nasopharyngeal swab specimen nonspecific occurred offer open pathologic pathological change pathological changes pathology pathophysiology Patient PCR performed Person pneumonias polymerase chain polymerase chain reaction Postmortem prevalent pulmonary Quantitative respiratory Result reverse transcriptase reverse transcriptase PCR Sample sampling subject Surveillance syndrome Teaching threshold thrombi tissue tissue biopsy Tuberculosis university Vascular Viral Viral pneumonia viral pneumonias
[DOI] 10.1093/cid/ciab858 PMC 바로가기 [Article Type] Supplement Articles

Mechanisms of thrombosis in ANCA-associated vasculitis

ANCA 관련 혈관염에서 혈전증의 기전

Review

Published on 2021-12-012022-09-11
Journal: Clinical Rheumatology [Category] MERS, SARS, 바이오마커, 진단, 치료기술,

[키워드] Activated neutrophils Activation anti-neutrophil cytoplasmic antibody Anti-neutrophil cytoplasmic antibody-associated vasculitis antibodies antibody antiphospholipid antibodies antiphospholipid antibody APL Blood caused circulation clotting cocaine contribute coronavirus disease Coronavirus disease 2019 COVID-19 cytoplasmic Deep vein Deep vein thrombosis described driving drug Embolism Embolism and thrombosis endothelial injury Endothelium ENhance expressing Extracellular greater homeostatic hydralazine Injury Levamisole mechanism Microparticle NET NETosis NETs neutrophil neutrophil activation Neutrophil extracellular trap Neutrophil extracellular traps Neutrophils occur pandemic pathogenic Patient Propylthiouracil Remission report resulting risk thrombi thrombogenesis thrombosis thrombotic thrombotic event Thrombotic events tissue Tissue Factor Trigger Vascular endothelium Vasculitis venous
[DOI] 10.1007/s10067-021-05790-9 PMC 바로가기 [Article Type] Review

Clinicopathological findings in patients with COVID-19-associated ischaemic enterocolitis

코로나19 관련 허혈성 장염 환자의 임상병리학적 소견

Article

Published on 2021-12-012022-09-11
Journal: Histopathology [Category] SARS, 유전자 메커니즘,

[키워드] Abnormalities affecting aims bowel characteristic Cohort coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection D-dimer level D-dimer levels decompensation elevated evaluate Evidence evidence of examined feature FIBRIN fibrin thrombi Gastrointestinal gastrointestinal tract histological histopathological finding histopathological findings hypercoagulable Hypercoagulable state intubation ischaemic enterocolitis mechanism microthrombi Most patient Most patients muscularis propria Necrosis neutrophil Patient patients perivascular pneumatosis proliferation required respiratory tract infection severe COVID-19 Severe COVID-19 Infection significantly more small intestine small vessel surgery thrombi vessel with COVID-19
[DOI] 10.1111/his.14457 PMC 바로가기 [Article Type] Article