Incidence of thromboembolic complications in hospitalized COVID-19 patients in a medical ward in Japan: A single-center retrospective and prospective observational studyObservational Study Published on 2022-08-192022-10-05 Journal: Medicine [Category] 임상, [키워드] 95% CI addition Admission age Asian Asymptomatic body mass index complications of COVID-19 conducted COVID-19 COVID-19 patient Critical determine died events hallmark higher risk hospital hospitalized COVID-19 patient identify incidence intensive care IQR Ischemia Japan Japanese limb median Mild moderate Myocardial infarction occurred Patient Prevalence Primary outcome prospective cohort study prospective observational study Prospective Study retrospective Severe case severe COVID-19 severe COVID-19 patient severity of COVID-19 single-center stroke symptomatic the median thromboembolic complication thromboembolic complications transferred Venous Thromboembolism women [DOI] 10.1097/MD.0000000000029933 PMC 바로가기 [Article Type] Observational Study
Dysregulation of the kallikrein-kinin system in bronchoalveolar lavage fluid of patients with severe COVID-19Research article Published on 2022-08-052022-10-05 Journal: EBioMedicine [Category] SARS, 바이오마커, 유전자 메커니즘, 진단, 치료기술, [키워드] ACE2 acute respiratory syndrome angiotensin-converting enzyme 2 BAL BAL fluid bind Biomarker Bronchoalveolar lavage Bronchoalveolar lavage fluid Coagulation system complexes contribute coronavirus COVID COVID-19 Critical dysregulation explain extracellular traps finding funding help hydrolytic activity Hypothesis increased vascular permeability inflammatory chemokines kallikrein-kinin Kallikrein-kinin system Kallikreins Kinins Leuven mechanically ventilated mechanically ventilated patient median myeloperoxidase NETs Neutrophil extracellular trap observation occur oedema Patient patients without COVID-19 peptide peptides plasma potential treatment option receptor Research SARS-CoV-2 severe COVID-19 severe pulmonary disease Support thromboembolic complication thromboembolic complications Thromboinflammation tissue [DOI] 10.1016/j.ebiom.2022.104195 [Article Type] Research article
Thromboembolic events in COVID-19 ambulatory patients: An observational study about incidence, and thromboprophylaxis outcomesObservational Study Published on 2022-08-042022-10-05 Journal: PLoS ONE [Category] 임상, [키워드] age ambulatory patients Cohort Complication complications conducted COVID-19 defined described eight event FIVE Hemorrhagic hemorrhagic event high risk incidence LMWH management occurred outcome Patient prophylactic strategy rivaroxaban thromboembolic complication Thromboprophylaxis venous venous thromboembolic [DOI] 10.1371/journal.pone.0270195 PMC 바로가기 [Article Type] Observational Study
Anticoagulation Strategies in Critically Ill Patients With SARS-CoV-2 Infection: The Role of Direct Thrombin InhibitorsObservational Study Published on 2022-08-012022-10-05 Journal: Journal of cardiothoracic and vascular anesthesia [Category] SARS, 임상, [키워드] acute respiratory syndrome addition Anticoagulant anticoagulation bivalirudin bleeding bleeding event Cohort comparable coronavirus Critical Critical care Critically ill patient Direct effective extracorporeal membrane oxygenation hospital Ill Infection intensive care intravenous measurement Mortality mortality risk no difference Occurrence participant Patient patients treated receiving role Safe SARS-CoV-2 SARS-COV-2 infection Strategy subgroup analysis Support thromboembolic complication thrombotic complication university hospital [DOI] 10.1053/j.jvca.2022.03.004 PMC 바로가기 [Article Type] Observational Study
Hemi- and Central Retinal Vein Occlusion Associated with COVID-19 Infection in Young Patients without Known Risk FactorsResearch article Published on 2022-06-012022-10-05 Journal: Ophthalmology. Retina [Category] 바이오마커, 변종, [키워드] age Anti-VEGF association Case series case sery Clinical course Complete Confirmed COVID-19 infection coronavirus disease counting fingers COVID-19 COVID-19 diagnosis COVID-19 infection diabetes edema event exclusion criteria eye Factor Final Follow-up follow-up period Hemi Hospitalization Hospitalized hypercoagulable states hypertension Infection Injections Intubated intubation macular edema measure median median age median time multicenter obesity ocular ophthalmic Patient potential risk presenting raise raised ranged reported Result Retinal vascular disease retinal vein retinal vein occlusion retrospective Symptom thromboembolic complication treated Vascular Venous Thromboembolism visual acuity with COVID-19 [DOI] 10.1016/j.oret.2022.02.004 [Article Type] Research article
Genetic determinants of mannose-binding lectin activity predispose to thromboembolic complications in critical COVID-19 Research Published on 2022-05-272022-10-05 Journal: Nature Immunology [Category] 유전자 메커니즘, 치료법, [키워드] COVID-19 Critical genetic determinant thromboembolic complication [DOI] 10.1038/s41590-022-01227-w [Article Type] Research
Reply to: Hultström et al., Genetic determinants of mannose-binding lectin activity predispose to thromboembolic complications in critical COVID-19. Mannose-binding lectin genetics in COVID-19 Research Published on 2022-05-272022-10-05 Journal: Nature Immunology [Category] 유전자 메커니즘, 임상, [키워드] COVID-19 Critical genetic determinant genetics Reply thromboembolic complication [DOI] 10.1038/s41590-022-01228-9 [Article Type] Research
COVID-19 and thrombosis: The role of hemodynamicsReview article Published on 2022-04-012022-10-05 Journal: Thrombosis research [Category] COVID19(2023년), SARS, 진단, [키워드] addition addressed adverse outcome Affect Brain characterized classical coronavirus disease COVID-19 COVID-19 case Critical crux Cytokine storm diagnostic Disseminated intravascular coagulation dysfunction Effect endothelial injury expressed Factor growth hemodynamic Hemodynamics hypercoagulability hypothese increased risk Injury investigated kidneys Lungs mechanism Microvascular thrombosis neutrophil offer organ pathway Patient Patient care platelet activation responsible sepsis-induced coagulopathy severe COVID-19 Shear stress Stress the disease therapeutic option thromboembolic complication Thromboembolic events Thromboembolism thrombosis thrombotic thrombotic event thrombus formation venous while [DOI] 10.1016/j.thromres.2022.02.016 [Article Type] Review article
SARS-CoV-2 Spike Protein 1 Activates Microvascular Endothelial Cells and Complement System Leading to Platelet AggregationSARS-CoV-2 스파이크 단백질 1은 미세혈관 내피 세포 및 보체 시스템을 활성화하여 혈소판 응집을 유도합니다Article Published on 2022-03-072022-09-11 Journal: Frontiers in Immunology [Category] SARS, 치료기술, [키워드] ACE2 Activation addition adhesive molecule aggregate aggregation AMPK amplified Analysis angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 antibody blockade blocking antibody Blot C3a C5a circulating complement Complement activation complement inhibitors complement system complexity conditions coronavirus disease Coronavirus disease 2019 COVID-19 detection element ELISA endothelial Endothelial cell endothelial cells endothelial damage Endothelial dysfunction enzyme evaluated Exocytosis experiment expression human host immunofluorescence incubated induce infect Inflammation Inflammatory inhibitors investigated leading leukocyte lung Microvascular thrombosis microvasculature Mortality multiorgan failure P-selectin performed phenotype Platelet platelet aggregation pro-inflammatory recruitment replicate robust S1 protein SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 spike protein 1 selectin sera severe COVID-19 patient severe COVID-19 patients significant level spike Spike protein System thromboembolic thromboembolic complication thromboembolic complications thrombomodulin thrombosis thrombotic thrombotic complication Thrombotic complications viral infection von Willebrand factor were assessed western blot Western blot analysis [DOI] 10.3389/fimmu.2022.827146 PMC 바로가기 [Article Type] Article
Proposed mechanism for rare thrombotic events after use of some Covid-19 vaccinesResearch article Published on 2022-02-012022-10-05 Journal: Medical Hypotheses [Category] 변종, [키워드] Adenoviridae Adenovirus affected antibody binding caused Coagulation complex COVID-19 vaccines described DNA Factor X healthcare immune response Immunity Impaired impairment individuals mechanism Mutation offer option Platelet platelet activation PROTECT Protein stimulate thrombocytopenia thromboembolic complication Thromboembolic event thrombotic event Vaccine Vaccines Venous thrombosis virus [DOI] 10.1016/j.mehy.2021.110756 [Article Type] Research article