A triple-RBD-based mucosal vaccine provides broad protection against SARS-CoV-2 variants of concernArticle Published on 2022-11-012022-11-15 Journal: Cellular and Molecular Immunology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] antibodies antigenic chimeric correlated Delta effective elicit flagellin Flagellin adjuvant human ACE2 IgA immunization Infection initial intranasal intranasal immunization Lower lung mucosal mucosal vaccine Mutation nasal neutralizing antibody neutralizing immunity omicron pathology Protein provide RBD reduce SARS-CoV-2 SARS-CoV-2 variant secretory IgA significantly specificity Spread tissue pathology transgenic mice transmission potential Triple-RBD Vaccine vaccine candidate variant variant of concern Viral RNA [DOI] 10.1038/s41423-022-00929-3 PMC 바로가기
A systematic analysis of ultrastructural lesions in the Plasmodium coatneyi splenectomized rhesus macaque model of severe malariaArticle Published on 2022-09-302024-09-10 Journal: Vet Pathol [Category] 말라리아, [키워드] malaria Plasmodium coatneyi rhesus macaque tissue pathology ultrastructure. PMC 바로가기
The Delta SARS-CoV-2 Variant of Concern Induces Distinct Pathogenic Patterns of Respiratory Disease in K18-hACE2 Transgenic Mice Compared to the Ancestral Strain from WuhanDelta SARS-CoV-2 변종은 우한의 조상 균주와 비교하여 K18-hACE2 형질전환 마우스에서 호흡기 질환의 뚜렷한 병원성 패턴을 유도합니다Article Published on 2022-06-282022-09-11 Journal: mBio [Category] COVID19(2023년), SARS, 변종, [키워드] Analysis B cells Brain caused CD45 Cell cells clinical disease concern coronavirus COVID-19 COVID-19 pandemic COVID-19 vaccine COVID-19 vaccines Cytokines Delta delta variant dendritic cell dendritic cells disease dissemination hACE2 help Immune escape immune response Increased Infection infiltration Inflammatory inflammatory monocytes intestinal wall intestine K18-hACE2 K18-hACE2 mice K18-hACE2 transgenic mice kidney lung Lungs manifestation mice Monocytes mouse model multiple tissues no significant difference observation Pathogenesis pathogenicity pattern perivascular inflammation Proinflammatory cytokine proinflammatory cytokines provide respiratory SAME AS SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants severe COVID-19 shown significant difference significantly lower strain T cells the disease therapeutic intervention therapeutic interventions Therapies tissue damage tissue pathology Transmissibility Treatment strategies two groups variant Wuhan [DOI] 10.1128/mbio.00683-22 PMC 바로가기 [Article Type] Article
Intravenous administration of BCG protects mice against lethal SARS-CoV-2 challengeBCG의 정맥 투여는 치명적인 SARS-CoV-2 공격으로부터 마우스를 보호합니다Brief Definitive Report Published on 2022-02-072022-09-10 Journal: The Journal of Experimental Medicine [Category] COVID19(2023년), MERS, SARS, 변종, [키워드] addition Administered alteration Analysis bacille Calmette-Guérin BCG BCG vaccination Cell cellular compartment clinically COVID-19 cytokine cytokine production Host immunopathology increase in Inflammatory inflammatory cell innate response intravenous Intravenous administration long-lasting mechanism mice Multivariate analysis myeloid cell nonspecific Pathogens pediatric phenomenon promote PROTECT provide pulmonary immune response recruitment reduced viral load reduced viral loads reducing reductions reductions in reported SARS-CoV-2 SARS-COV-2 infection subcutaneous route tissue pathology transgenic mice Tuberculosis vaccination variant Viral Viral load virus while [DOI] 10.1084/jem.20211862 PMC 바로가기 [Article Type] Brief Definitive Report
JIB-04 Has Broad-Spectrum Antiviral Activity and Inhibits SARS-CoV-2 Replication and Coronavirus PathogenesisResearch Article Published on 2022-01-182022-10-29 Journal: mBio [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] 50% effective concentration activity acute respiratory syndrome administration Antiviral antiviral activity Antiviral agents approach bronchial epithelial cells cell types compound screening coronavirus Coronavirus infection DNA and RNA gastroenteritis global public health greater highlight in vitro in vivo inhibited inhibitor JIB-04 reduced Replication reporter SARS-CoV-2 SARS-CoV-2 replication specificity survival tissue pathology utility Vero E6 cell viral pathogens virus virus infection viruses [DOI] 10.1128/mbio.03377-21 PMC 바로가기 [Article Type] Research Article
Hamster organotypic modeling of SARS-CoV-2 lung and brainstem infectionArticle Published on 2021-10-042022-10-04 Journal: Nature Communications [Category] SARS, 유전자 메커니즘, 치료제, [키워드] acute respiratory syndrome Anti-viral antivirals Apoptosis Brain can be used cause caused cell death Central nervous system characterized complex compounds COVID-19 Culture Evidence Ex vivo global pandemic granular hamster immune response induce infect Infection innate immune response Interaction interferon Local lung lung tissue necroptosis neurological neurons offer organ pyroptosis SARS-CoV-2 spread to tissue pathology unique viral infection viral pathogenesis viral tropism virus [DOI] 10.1038/s41467-021-26096-z PMC 바로가기 [Article Type] Article
Aging and Interferons: Impacts on Inflammation and Viral Disease OutcomesReview Published on 2021-03-232022-10-31 Journal: Cells [Category] COVID-19, SARS, [키워드] Adaptive immune response aging antiviral response cause COVID-19 Critical death dendritic cell disease pathology dysregulation Elderly patient Evidence exacerbated function global pandemic IFN IFN response IFNs immune activation immune response Immune-mediated immunopathology immunosuppressive Impact impairment implication individual individuals Infection Inflammation Inflammatory inflammatory immune responses interferon involved Macrophage magnitude majority monocyte/macrophages outcome pathology Prevent promote Regulation response Severe infection Support tissue pathology treat type I Type I IFN type II IFN Type III IFN understanding viral infection viral replication [DOI] 10.3390/cells10030708 PMC 바로가기 [Article Type] Review