Persistent olfactory dysfunction after COVID-19 is associated with reduced perfusion in the frontal lobeCOVID-19 이후 지속되는 후각 기능 장애는 전두엽의 감소된 관류와 관련이 있습니다Article Published on 2022-08-012022-09-11 Journal: Acta neurologica Scandinavica [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute infection analysis Anosmia association Brain Brain mapping brain region Central nervous system changes in conducted COVID-19 dysfunction evaluate identification labeling MRI nasal Neuroimaging olfactory olfactory dysfunction olfactory test paranasal Paranasal sinuses pathophysiology Patient performed persistence persistent post-COVID syndrome. reduced Region SARS-COV-2 infection sequence Smell statistically significant Symptom syndrome Test tissue tissue perfusion Volume Voxel were assessed White matter [DOI] 10.1111/ane.13627 PMC 바로가기 [Article Type] Article
The interacting physiology of COVID-19 and the renin-angiotensin-aldosterone system: Key agents for treatmentCOVID-19와 레닌-안지오텐신-알도스테론 시스템의 상호작용 생리: 치료의 핵심 인자Review Published on 2022-02-012022-09-11 Journal: Pharmacology Research & Perspectives [Category] COVID19(2023년), SARS, 신약개발, [키워드] ACE2 Activation aldosterone alteration Ang II angiotensin Angiotensin II Angiotensin-converting enzyme angiotensin-converting enzyme 2 Arm circulating circulation circulatory system contrary conversion COVID-19 destruction dysregulated Effect Effects enzyme fluids homeostasis Host host response Infection Inflammation Inflammatory response Injury limit maintain metabolism Pathogenesis pathogenesis of COVID-19 peptide pro-inflammatory action pro-inflammatory actions RAAS receptor regulated Renin renin-angiotensin system renin-angiotensin-aldosterone system respond responsible SARS-CoV-2 steroid steroid hormone Therapies therapies. tissue tissue perfusion trauma Treatment turn viral infection Volume [DOI] 10.1002/prp2.917 PMC 바로가기 [Article Type] Review
Efficacy and safety of intramuscular administration of allogeneic adipose tissue derived and expanded mesenchymal stromal cells in diabetic patients with critical limb ischemia with no possibility of revascularization: study protocol for a randomized controlled double-blind phase II clinical trial (The NOMA Trial)혈관재생 가능성이 없는 위독한 사지 허혈이 있는 당뇨병 환자에서 동종 지방 조직 유래 및 확장 중간엽 기질 세포의 근육내 투여의 효능 및 안전성: 무작위 대조 이중 맹검 2상 임상 시험을 위한 연구 프로토콜(The NOMA Trial)Study Protocol Published on 2021-09-062022-09-10 Journal: Trials [Category] SARS, 비임상, 임상, [키워드] adipose Adipose tissue Adipose-derived mesenchymal stromal cells Administered administration Advanced therapy medicinal products adverse event adverse events Allogeneic Angiogenesis animal model animal models antiplatelet assigned breath Cell Cell therapy chronic clinical development Clinical practice clinical trial control group Critical Critical limb ischemia current data set demonstrated develop diabetes Diabetes Mellitus diabetic patient dose double-blind Efficacy eligible patient evaluate evaluated feasibility Health Organization health problem humans IMPROVE induce intramuscular Ischemia life limb lower limb Mesenchymal stromal cells multicenter outcome parameters Patient Phase II clinical trial placebo-controlled trial Primary outcome protocol public health Quality of life Randomized Randomly Registration Research revascularization secondary Secondary outcomes shown statins step stromal cell stromal cells study period Study protocol Tertiary the disease therapeutic therapeutic option therapeutic options therapy tissue tissue perfusion Treatment treatment group Trial registration type 2 diabete Type 2 diabetes mellitus World Health Organization [DOI] 10.1186/s13063-021-05430-2 PMC 바로가기 [Article Type] Study Protocol