NLRC5 senses NAD + depletion to form a PANoptosome driving PANoptosis and inflammationArticle Published on 2024-06-122024-09-05 Journal: Cell [Category] update2024, [키워드] Apoptosis ASC caspase caspase-1 caspase-3 caspase-7 caspase-8 Colitis creatinine DAMP DSS gasdermin D gasdermin E heme Hemolysis hemophagocytic lymphohistiocytosis Inflammasome Inflammation Inflammatory cell death LPS MLKL necroptosis nicotinamide adenine dinucleotide NLRC5 NLRP12 NLRP3 Pam3CSK4 PAMP PANoptosis PANoptosome Phenylhydrazine poly(I:C) pyroptosis RIPK3 ROS TLR2 TLR4 TLRs TNF [DOI] 10.1016/j.cell.2024.05.034 PMC 바로가기 [Article Type] Article
Mechanistic insights into SARS-CoV-2 spike protein induction of the chemokine CXCL10Article Published on 2024-05-162024-09-05 Journal: Scientific Reports [Category] update2024, [키워드] biomedical engineering CXCL10 (IP-10) Glycogen synthase kinase-3 IRF NF-κB SARS-CoV-2-Spike Protein Target identification TLR2 viral infection [DOI] 10.1038/s41598-024-61906-6 PMC 바로가기 [Article Type] Article
SARS-CoV-2 envelope protein triggers depression-like behaviors and dysosmia via TLR2-mediated neuroinflammation in micearticle Published on 2023-05-082024-09-05 Journal: Journal of Neuroinflammation [Category] update2024, [키워드] COVID-19 Depression dysosmia E protein TLR2 [DOI] 10.1186/s12974-023-02786-x PMC 바로가기 [Article Type] article
An epithelial-immune circuit amplifies inflammasome and IL-6 responses to SARS-CoV-2Article Published on 2023-02-082023-07-11 Journal: Cell Host & Microbe [Category] COVID19(2023년), [키워드] AIM2 IL-1β IL-6 Inflammasome NLRP1 NLRP3 SARS-CoV-2 STING TLR2 [DOI] 10.1016/j.chom.2022.12.005 PMC 바로가기
Toll-like receptor-2 (TLR-2) rs111200466 variant offers protection against SARS-CoV-2 infections and mortality: a worldwide epidemiological correlation analysisArticle Published on 2023-01-012023-07-11 Journal: Nucleosides, nucleotides & nucleic acids [Category] COVID19(2023년), [키워드] correlation COVID-19 Infection Mortality rs111200466. SARS-CoV-2 TLR2 [DOI] 10.1080/15257770.2022.2151015
Mycoplasma pneumoniae Compared to Streptococcus pneumoniae Avoids Induction of Proinflammatory Epithelial Cell Responses despite Robustly Inducing TLR2 Signaling마이코플라스마 폐렴균은 스트렙토코쿠스 폐렴균에 비해 강력하게 TLR2 신호를 유도하면서도 염증성 상피 세포 반응의 유도를 피한다.Article Published on 2022-08-182024-08-24 Journal: Infection and Immunity [Category] 폐렴구균 감염증, [키워드] host response IL-33 IL-8 Mycoplasma pneumoniae Pneumonia primary bronchial epithelial cells Respiratory pathogens Streptococcus pneumoniae TLR10 TLR2
Bioinformatics analysis of potential pathogenesis and risk genes of immunoinflammation-promoted renal injury in severe COVID-19Article Published on 2022-08-162022-11-15 Journal: Frontiers in Immunology [Category] 바이오마커, [키워드] activated addition Algorithm ALOX5 Analysis bioinformatics caused CD38 Cell characterized clinical utility correlated COVID-19 COVID-19 patient COVID-19 patients cytokine cytokine receptor dataset dendritic cells enrichment analysis expression expression pattern gene co-expression network Genes glomerular filtration rate HCK identify immune Immune cell Immune cell infiltration Including independent data set indicated Inflammation Inflammatory Injury Interaction involved ischemia-reperfusion injury ITGAX KEGG LYN macrophages MAPK3 Mild Miner moderate NCF4 necroptosis network analysis Neutrophils nomogram Pathogenesis pathway Pathways performed Peripheral blood poor prognosis PPI progression promoted protein-protein interaction random renal renal injury risk screened SELP Sequencing analysis severe COVID-19 SPI1 STEM TLR2 TLR4 toll-like receptor signaling transcriptomic Viral protein WGCNA [DOI] 10.3389/fimmu.2022.950076 PMC 바로가기
Platelets in the NETworks interweaving inflammation and thrombosis염증과 혈전을 뒤섞는 NETworks의 혈소판Review Published on 2022-08-012022-09-11 Journal: Frontiers in Immunology [Category] 치료기술, 치료제, [키워드] activate Bacterial Capillaries capillary characterized chemokine chemokines chromatin Clinical outcome Coagulation factors contribute contributing to Course COVID-19 COVID-19 pandemic COVID-19 patient Cytokine storm disease DNA engage ENhance Evidence expression Extracellular extracellular space Growth factors hemorrhage Hemostasis histone Histones host innate immunity immune response immunothrombosis IMPROVE increased mortality induce infiltration Inflammation Inflammatory diseases inflammatory signaling Interaction interface kill lesion lung majority mechanism microthrombi molecular mechanism NET NETs neutrophil neutrophil activation Neutrophil extracellular trap Neutrophil extracellular traps neutrophil infiltration Neutrophils other tissue other tissues pathogen Pathogens Pathways Patient Pattern recognition Pattern recognition receptors Platelet Platelets procoagulant Protein Proteins provide provided resulting signaling pathway subsequent surface expression survival target thrombi thrombosis thrombotic TLR2 TLR4 Topic TRAP Treatment vascular beds virus [DOI] 10.3389/fimmu.2022.953129 PMC 바로가기 [Article Type] Review
CLEC5A and TLR2 are critical in SARS-CoV-2-induced NET formation and lung inflammationArticle Published on 2022-07-112023-07-10 Journal: Journal of Biomedical Science [Category] COVID19(2023년), [키워드] acute respiratory distress syndrome CLEC2 CLEC5A COVID-19 immunothrombosis Neutrophil extracellular traps Platelets SARS-CoV-2 Spike protein TLR2 [DOI] 10.1186/s12929-022-00832-z PMC 바로가기
Immunoinformatic approach for the construction of multi-epitopes vaccine against omicron COVID-19 variant오미크론 COVID-19 변이체에 대한 다중 에피토프 백신 구축을 위한 면역정보학적 접근Article Published on 2022-07-012022-09-11 Journal: Virology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] added adjuvant antigenic antigenic epitope antigenic epitopes applied approach B cell epitope B cell epitopes B-cell B.1.1.529 CD4 CD8 chimeric Chimeric vaccine model codon optimization complexes computational tool computational tools concern construction country COVID-19 COVID-19 omicron variant effective epitope Epitopes expression Final flexible Health Organization help highly antigenic Host IFN-γ immune mechanism immunogenic in-silico increasingly inducer initiative linker MEV MHC-II molecular molecular docking molecular dynamics mutagenic N-terminal non-allergenic non-toxic omicron Omicron variant overlapping peptide peptide-based planet Protein reverse vaccinology SARS-CoV-2 SARS-CoV-2 infections SARS-CoV-2 variant Scientific community Simulation spike Spike protein stability suggested T-cell T-cell epitopes TLR TLR2 TLR4 TLRs toxic treat unique vaccination Vaccine vaccine candidate variant VoC WHO World Health Organization [DOI] 10.1016/j.virol.2022.05.001 PMC 바로가기 [Article Type] Article