Preparation and pre-clinical evaluation of flagellin-adjuvanted NOM vaccine candidate formulated with Spike protein against SARS-CoV-2 in mouse modelArticle Published on 2022-10-012022-11-15 Journal: Microbial pathogenesis [Category] COVID19(2023년), SARS, 진단, [키워드] 3D structure acute respiratory syndrome Analysis anti-S Antigen Antisera bind Cell Cell-mediated immune responses chimeric China Cluster coronavirus cytokine develop docking effective elicit ELISA ENhance evaluated expressed flagellin groups humoral IFN-γ IgG IL-10 IL-17 IL-22 IL-6 immune response immunoinformatics indicated Infection Interaction mice Ni-NTA NOM protein ORF3a outbreak performed pneumonia case preparation promoted Protein purified raised receptor S protein Salmonella SARS-CoV-2 significantly increased spike spleen TLR5 TNF-α Total vaccination Vaccine vaccine candidate vaccine candidates was selected were assessed Wuhan [DOI] 10.1016/j.micpath.2022.105736 PMC 바로가기
Flagellin From Pseudomonas aeruginosa Modulates SARS-CoV-2 Infectivity in Cystic Fibrosis Airway Epithelial Cells by Increasing TMPRSS2 ExpressionImmunology Published on 2021-12-072022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, SARS, [키워드] Activation AEC airway angiotensin-converting enzyme 2 Calu-3 cell calu-3 cells CFTR chronic respiratory disease coronavirus disease Course COVID-19 COVID-19 severity COVID19 Critical Cystic cystic fibrosis deficiency develop epithelial cell Factor fibrosis flagella flagellin Health host protease identify immune response increase Increasing infect Infection Infectivity MAPK modulation P. aeruginosa Patient patients populations protease Protein Pseudomonas aeruginosa receptor recommendation reduce released risk of COVID-19 SARS-CoV-2 SARS-COV-2 infection susceptibility TLR5 TMPRSS2 TMPRSS2 expression transmembrane transmembrane serine protease urgency virus particle [DOI] 10.3389/fimmu.2021.714027 PMC 바로가기 [Article Type] Immunology
Effects of Bacille Calmette Guerin (BCG) vaccination during COVID-19 infectionResearch article Published on 2021-11-012022-10-05 Journal: Computers in biology and medicine [Category] SARS, 바이오마커, 변종, [키워드] activities acute respiratory syndrome ADORA3 analysed Analysis Bacille calmette guerin (BCG) BCG BCG vaccination caused CCL4 CCR2 CD33 Comorbidity condition contagious coronavirus coronavirus disease COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 patient COVID‐19 Critical CXCL1 CXCL8 cytokine DEGs differentially expressed gene Differentially expressed genes driving drug candidate Drug molecules Effect elements enrichment analysis expression expression pattern finding functional Functional enrichment analysis Gene ontology Genes Genetic IFNg IL-17 Infection Interaction investigated ITGB2 miRNA molecular mononuclear cell more difficult Mortality network analysis Novel coronavirus pandemic pathway Pathways PBMC Peripheral blood PPI PTGS2 Regulatory Research SARS-CoV-2 SARS-COV-2 infection severity significantly Spread TFS therapeutic TLR5 transcriptomic vaccination Vaccine virus spread [DOI] 10.1016/j.compbiomed.2021.104891 [Article Type] Research article
Evaluation of the Effect of Inactivated Transmissible Gastroenteritis Virus Vaccine with Nano Silicon on the Phenotype and Function of Porcine Dendritic CellsArticle Published on 2021-10-262022-10-28 Journal: Viruses [Category] Coronavirus, MERS, [키워드] Activation characterized coronavirus cytokine cytokine receptor DCs dendritic cell disease Effect ENhance function gastroenteritis help IFN-α IL-12 IL-1β IL-6 immature immune responses inactivated inactivated TGEV vaccine indicated Innate immunity mechanism MSN nano silicon phenotype Research Safe significantly higher silicon TGEV TLR10 TLR3 TLR5 TLR7 TLR9 TNF-α Vaccine virus [DOI] 10.3390/v13112158 PMC 바로가기 [Article Type] Article
Consider TLR5 for new therapeutic development against COVID-19Comment Published on 2020-11-012023-07-11 Journal: Journal of medical virology [Category] SARS, [키워드] COVID-19 therapeutic development. TLR5 [DOI] 10.1002/jmv.25997 PMC 바로가기 [Article Type] Comment
Attenuated Subcomponent Vaccine Design Targeting the SARS-CoV-2 Nucleocapsid Phosphoprotein RNA Binding Domain: In Silico AnalysisResearch Article Published on 2020-09-172022-10-29 Journal: Journal of Immunology Research [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome analyzed Antigen antigenic antigenic peptide antigenicity B cell binding domain C-terminal caused CD4 CD8 chimeric coronavirus COVID-19 creating effective Efficiency expression humans hypersensitivity reaction immunogenic In silico cloning in viral linear epitope MHC-I MHC-II alleles molecular docking molecular interaction N-terminal novel coronavirus disease nucleocapsid protein pandemic peptide Phosphoprotein predicted provide public health Replication Research RNA Safe SARS-CoV-2 selected Selected epitopes T cell epitope targeting the SARS-CoV-2 the vaccine TLR5 Toxicity translation triggered Vaccine was performed [DOI] 10.1155/2020/2837670 PMC 바로가기 [Article Type] Research Article
Microneedle array delivered recombinant coronavirus vaccines: Immunogenicity and rapid translational developmentResearch paper Published on 2020-04-022022-11-01 Journal: EBioMedicine [Category] COVID-19, MERS, SARS, [키워드] 2019-nCoV agonists antibody antigen-specific antibody building characteristic clinical development clinical trials coronavirus Coronavirus infection COVID-19 COVID-19 disease COVID-19 vaccines develop Diseases domain effort elicited ELISA evidenced finding fused Health immune immune response immunization immunogenicity in vivo induce infectious agent injection long-lasting MERS MERS-CoV MERS-CoV S1 MERS-CoV vaccine MERS-CoV vaccines mice Microneedle microneedle array Middle East MNA MOST Novel coronavirus Outbreaks Pandemics produced Progressive Protein protein subunit vaccine respiratory response responses SARS-CoV SARS-CoV-2 SARS-CoV-2 S1 sequence serum specific IgG antibody subcutaneously Subunit vaccine subunit vaccines Support tested the SARS-CoV-2 TLR4 TLR5 translational trimeric trimerization Vaccine variant viral envelope virus virus neutralization assays [DOI] 10.1016/j.ebiom.2020.102743 PMC 바로가기 [Article Type] Research paper
In vivo effect of a TLR5 SNP (C1205T) on Salmonella enterica serovar Typhimurium infection in weaned, specific pathogen-free Landrace pigletsarticle Published on 2018-06-302024-09-01 Journal: Microbiology and Immunology [Category] 살모넬라증, [키워드] pig salmonellosis Salmonella Typhimurium Single nucleotide polymorphism TLR5 [Article Type] article
Polymorphism of TLR5 rs5744174 is associated with disease progression in Chinese patients with chronic HBV infectionArticle Published on 2017-08-012023-06-16 Journal: Apmis [Category] B형 간염, [키워드] Chinese Hepatitis B virus PCR Sequencing Single nucleotide polymorphism TLR5 [DOI] 10.1111/apm.12707
Flagellin-dependent TLR5/caveolin-1 as a promising immune activator in immunosenescence면역노화에서 유망한 면역 활성제인 플라젤린 의존 TLR5/카베올린-1Original Article Published on 2015-10-302024-08-04 Journal: Aging Cell [Category] 폐렴구균 감염증, [키워드] caveolin-1 flagellin immunosenescence TLR5 vaccine adjuvant [DOI] 10.1111/acel.12383 PMC 바로가기 [Article Type] Original Article