CpG DNA-triggered upregulation of TLR9 expression affects apoptosis and immune responses in human plasmacytoid dendritic cells isolated from chronic hepatitis B patientsArticle Published on 2023-04-012023-06-13 Journal: Archives of physiology and biochemistry [Category] B형 간염, [키워드] Apoptosis CpG DNA immune response pDCs. TLR9 [DOI] 10.1080/13813455.2020.1822414
Nucleic acid-sensing toll-like receptors: Important players in Sjögren’s syndromeReview Published on 2022-10-312023-07-10 Journal: Frontiers in Immunology [Category] COVID19(2023년), [키워드] Autoimmunity COVID-19 nucleic acid-sensing TLRs Sjögren’s syndrome systemic lupus erythematosus TLR7 TLR8 TLR9 [DOI] 10.3389/fimmu.2022.980400 PMC 바로가기 [Article Type] Review
Individual genetic variability mainly of Proinflammatory cytokines, cytokine receptors, and toll-like receptors dictates pathophysiology of COVID-19 disease주로 전염증성 사이토카인, 사이토카인 수용체 및 톨 유사 수용체의 개별 유전적 다양성이 COVID-19 질병의 병태생리를 좌우합니다Review Published on 2022-09-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, [키워드] acquired immunity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Alter B cells chemokine chemokines Clinical outcome clinical outcomes coding gene coding genes condition coronavirus coronavirus disease Coronavirus disease-19 Coronavirus-2 COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 severity cytokine Cytokine storm Cytokines determine exacerbate Gene Expression genes encoding Genetic genetic variability Genetic variation Genetic variations Host IL10 IL17 IL4 IL6 IL7 immune immune response immune responses Immunity individual Infection Inflammation Innate interferons Monocytes Mutation natural killer cell Natural killer cells Neutrophils nucleotide pathophysiology Patient polymorphism proinflammatory cytokines receptors respiratory symptoms response SARS-COV-2 infection Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe respiratory symptoms severity of COVID-19 Single nucleotide polymorphism single nucleotide polymorphisms SNP SNPs susceptibility T cells the patient TLR TLR3 TLR7 TLR9 TLRs TNF Toll-like receptor Toll-like receptors understanding variants of concern Variation viral infection viral infections VOCs [DOI] 10.1002/jmv.27849 PMC 바로가기 [Article Type] Review
Nanoparticle-delivered TLR4 and RIG-I agonists enhance immune response to SARS-CoV-2 subunit vaccine나노입자 전달 TLR4 및 RIG-I 작용제는 SARS-CoV-2 소단위 백신에 대한 면역 반응을 향상시킵니다Article Published on 2022-07-012022-09-11 Journal: Journal of controlled release : official journal o [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] activated Adaptive immune response adjuvant adjuvants agonist Anti-spike anti-Spike IgG Antibody titer Antibody titers Antigen antigen-presenting cell antigen-presenting cells APC APCS B cell B cells BAL Bcl6 Blood bronchoalveolar CD4 CD44 Cell cell population characterized Combination adjuvant COVID-19 COVID-19 protein subunit vaccine CpG DLNs draining lymph node draining lymph nodes Efficacy ENhance follicular Germinal center GL7 helper cell humoral immune responses IgA IgG immune immune response immune responses Immunity IMPROVE in vitro in vivo Increases increases in Infection intramuscular intramuscular vaccination intranasal Intranasal versus intramuscular vaccination intranasally lead lung Lungs lymphocyte memory T memory T cell mice molecular Monophosphoryl lipid A MPLA Native neutralizing antibody titers Pattern recognition pattern recognition receptor Pattern recognition receptors Polymer Population Proinflammatory cytokine Protein subunit protein subunit vaccine Protein subunit vaccines PRR PRRs PUUC reaction receptor receptors responses against retinoic acid retinoic acid-inducible gene I RIG-I robust S1 subunit SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein secretion spike IgA Spike protein stabilized spike protein stimulate subunit Subunit vaccine T cell T cell proliferation the S1 subunit TLR TLR4 TLR7 TLR7/8 TLR9 TLRs Toll-like receptor Toll-like receptors Transmission unique Vaccine vaccine availability vaccine responses variants [DOI] 10.1016/j.jconrel.2022.05.023 PMC 바로가기 [Article Type] Article
Receptor-binding domain recombinant protein on alum-CpG induces broad protection against SARS-CoV-2 variants of concernAlum-CpG의 수용체 결합 도메인 재조합 단백질은 우려되는 SARS-CoV-2 변이체에 대한 광범위한 보호를 유도합니다Article Published on 2022-06-092022-09-11 Journal: Vaccine [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] (Alpha) (Beta) addition adjuvant Alpha alum aluminum aluminum hydroxide Antibody titer Antibody titers B.1.1.529 B.1.1.7 B.1.351 B.1.617.2 benefit Beta Cellular immune response conducted Controller convalescent plasma Corbevax COVID-19 CpG Delta dose drug Emergency use authorization evaluated exceeded hydroxide immune response immunized induce Infection intramuscularly mice neutralization Neutralizing antibodies neutralizing antibody neutralizing antibody titers omicron other variants preclinical studies preclinical study Protein Receptor-binding domain reported SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 variant second dose subunit Subunit vaccine TLR9 TLR9 adjuvant Vaccine vaccine candidate variant variants variants of concern Virus neutralization Wuhan Wuhan isolate yeast [DOI] 10.1016/j.vaccine.2022.05.007 PMC 바로가기 [Article Type] Article
Preclinical In Silico Evidence Indicates the Pharmacological Targets and Mechanisms of Mogroside V in Patients With Ovarian Cancer and Coronavirus Disease 20192019년 난소암 및 코로나바이러스 질환 환자에서 모그로사이드 V의 약리학적 표적 및 메커니즘을 나타내는 전임상 인 실리코 증거Article Published on 2022-04-062022-09-11 Journal: Frontiers in Endocrinology [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 anticancer biological processe China clinical clinical observations coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19-related death docking drug target Effects endothelial enrichment analysis growth factor Hsp90 HSP90AA1 IL2 indicated ingredient Injury mechanism medication Mitigation Mogroside mogroside V molecular docking network pharmacology observation ovarian ovarian cancer pathway Pathways Patient Preclinical preclinical report PRKCA PRKCB reduce remedial targets. reported SARS-CoV-2 Siraitia STAT3 suggested target target protein targets therapeutic therapeutic agent therapeutic efficacy TLR7 TLR9 Transmission Vaccine variant Vascular VEGFA with COVID-19 [DOI] 10.3389/fendo.2022.845404 PMC 바로가기 [Article Type] Article
STING agonist diABZI induces PANoptosis and DNA mediated acute respiratory distress syndrome (ARDS)STING 효능제 diABZI, PANoptosis 및 DNA 매개 급성 호흡 곤란 증후군(ARDS) 유도Article Published on 2022-03-252022-09-11 Journal: Cell Death & Disease [Category] SARS, 치료법, [키워드] Activation acute lung inflammation acute respiratory distress AIM2 airway amplification amplifying Apoptosis apoptosis induction ARDS CASP8 caspase-3 cell death cGAS cleavage complex contribute Cytokines cytoplasm DDX41 dinucleotide Disruption DNA DNase I double-stranded dsDNA ENhance epithelial extracellular DNA followed by gasdermin D IFN IFN-I IFNAR1 IL-1β IL-6 immune response immune responses induce Infection inflammasomes Inflammation Inflammatory Inflammatory cytokine Inflammatory cytokines Inflammatory response interferon IRF3 low dose lung Lung inflammation mice MLKL necroptosis NET NETosis neutrophilic neutrophilic response NF-kB NF-kB pathway NLRP3 NLRP3 inflammasome nucleotide pathway Phosphorylation priming pro-inflammatory cytokine pro-inflammatory cytokines pyroptosis receptor RIPK3 SARS-COV-2 infection severe ARDS signaling pathway silica smoke stimulator STING subsequent suggested syndrome TBK1 therapeutic strategy TLR9 TNFR1 TNFα Treatment triggered Tumor tumors Type I IFN type I IFN response type I interferon upregulation viral infection ZBP1 [DOI] 10.1038/s41419-022-04664-5 PMC 바로가기 [Article Type] Article
Innate Immune Responses of Vaccinees Determine Early Neutralizing Antibody Production After ChAdOx1nCoV-19 VaccinationImmunology Published on 2022-01-252022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, [키워드] Activation adaptive adenoviral vector vaccine adenovirus vector vaccine age antibody Antibody titer association AZD1222 B cell CD14 CD27 CD3 CD56 CD86 Cell ChAdOx1 nCoV-19 collected connection correlated CpG Critical cytokine production double-negative B cell enrolled Ex vivo expression first vaccination FIVE flow cytometry granzyme B IFN-γ IGD imiquimod Immune cell immune response Immunity immunosenescence information Innate innate immune innate immune activation innate immune response Innate immunity LPS marker memory B cell monocyte naïve naïve B cell natural killer neutralization Neutralizing antibodies neutralizing antibody NK cell Older pattern recognition receptor Production response responses Result SARS-CoV-2 vaccines SARS-CoV2 serum significantly higher stimulated subject sVNT TLR TLR agonist TLR stimulation TLR9 Toll-like receptor vaccination vaccinee Virus neutralization were measured [DOI] 10.3389/fimmu.2022.807454 PMC 바로가기 [Article Type] Immunology
Evaluation of the Effect of Inactivated Transmissible Gastroenteritis Virus Vaccine with Nano Silicon on the Phenotype and Function of Porcine Dendritic CellsArticle Published on 2021-10-262022-10-28 Journal: Viruses [Category] Coronavirus, MERS, [키워드] Activation characterized coronavirus cytokine cytokine receptor DCs dendritic cell disease Effect ENhance function gastroenteritis help IFN-α IL-12 IL-1β IL-6 immature immune responses inactivated inactivated TGEV vaccine indicated Innate immunity mechanism MSN nano silicon phenotype Research Safe significantly higher silicon TGEV TLR10 TLR3 TLR5 TLR7 TLR9 TNF-α Vaccine virus [DOI] 10.3390/v13112158 PMC 바로가기 [Article Type] Article
Single-cell RNA sequencing of blood antigen-presenting cells in severe COVID-19 reveals multi-process defects in antiviral immunity Research Published on 2021-05-102022-10-05 Journal: Nature cell biology [Category] 바이오마커, 치료기술, [키워드] Admission Antigen presentation antigen-presenting cell Antiviral antiviral immunity APC APCS Blood COVID-19 dataset DCs decrease dendritic cell DHX36 downregulation effector explain healthy donors High-resolution histocompatibility complex immune inflammatory mediator intensive care interferon-stimulated gene life-threatening mechanism MHC MHC class monocyte pathway Patient patients with moderate pDC pDCs plasmacytoid DC pro-apoptotic Respiratory failure reveal RNA sequencing severe COVID-19 Severe COVID-19 pneumonia Single-cell RNA-sequencing subset TLR9 unique Viral load [DOI] 10.1038/s41556-021-00681-2 [Article Type] Research