Targeting Myeloid Differentiation Primary Response Protein 88 (MyD88) and Galectin-3 to Develop Broad-Spectrum Host-Mediated Therapeutics against SARS-CoV-2Review Published on 2024-08-012024-09-05 Journal: International Journal of Molecular Sciences [Category] update2024, [키워드] COVID-19 cytokine galectin-3 IFNs MYD88 NLRP3 PRR SARS-CoV-2 TLRs [DOI] 10.3390/ijms25158421 PMC 바로가기 [Article Type] Review
NLRC5 senses NAD + depletion to form a PANoptosome driving PANoptosis and inflammationArticle Published on 2024-06-122024-09-05 Journal: Cell [Category] update2024, [키워드] Apoptosis ASC caspase caspase-1 caspase-3 caspase-7 caspase-8 Colitis creatinine DAMP DSS gasdermin D gasdermin E heme Hemolysis hemophagocytic lymphohistiocytosis Inflammasome Inflammation Inflammatory cell death LPS MLKL necroptosis nicotinamide adenine dinucleotide NLRC5 NLRP12 NLRP3 Pam3CSK4 PAMP PANoptosis PANoptosome Phenylhydrazine poly(I:C) pyroptosis RIPK3 ROS TLR2 TLR4 TLRs TNF [DOI] 10.1016/j.cell.2024.05.034 PMC 바로가기 [Article Type] Article
TLR2/4 are novel activating receptors for SARS-CoV-2 spike protein on NK cellsImmunology Original Research Published on 2024-05-312024-09-05 Journal: Frontiers in immunology [Category] update2024, [키워드] NK-cell SARS-CoV2 spike glycoprotein TLRs variants of concerns [DOI] 10.3389/fimmu.2024.1368946 PMC 바로가기 [Article Type] Immunology Original Research
The Spike protein of SARS-CoV-2 signals via Tlr2 in zebrafishArticle Published on 2023-03-012023-07-11 Journal: Developmental and comparative immunology [Category] COVID19(2023년), [키워드] Hematopoiesis Inflammation interleukin-1 Spike protein TLRs zebrafish [DOI] 10.1016/j.dci.2022.104626 PMC 바로가기
Translational vaccinomics and structural filtration algorithm to device multiepitope vaccine for catastrophic monkeypox virusArticle Published on 2023-02-012023-06-09 Journal: Computers in biology and medicine [Category] Fulltext, 원숭이두창, [키워드] immunoinformatics Monkeypox virus multiepitope vaccine reverse vaccinology TLRs [DOI] 10.1016/j.compbiomed.2022.106497 PMC 바로가기
The TLR-NF-kB axis contributes to the monocytic inflammatory response against a virulent strain of Lichtheimia corymbifera, a causative agent of invasive mucormycosisArticle Published on 2022-10-132022-11-15 Journal: Frontiers in Immunology [Category] 진단, [키워드] 24 hours activated Activation Apoptosis apoptotic cascade caused Cell cell damage characterized contribute COVID-19 CTLs Cytokines Diabetes Mellitus Diagnosis Diseases ENhance exhibit fungal Fungal infection fungi Hematological malignancies host cell Host immune response host inflammatory response host-pathogen interactions human monocyte human monocytes IL-1β IL-6 increase in individual Infection Inflammatory Inflammatory response inflammatory signaling Interaction invasive killing life-threatening modulation monocyte mortality rate Mucorales Mucormycosis NF-kB Occurrence organ pathogenic phagocyte phagocytosis priming pro-inflammatory cytokine produced progression PRRs receptor receptors regulate secreted signaling pathway spore susceptible synergistic therapy TLR TLR4 TLRs TNF-α Toll-like receptor transcription factor virulent [DOI] 10.3389/fimmu.2022.882921 PMC 바로가기
Toll-like Receptor Mediation in SARS-CoV-2: A Therapeutic ApproachArticle Published on 2022-09-142022-11-15 Journal: International Journal of Molecular Sciences [Category] SARS, 치료제, [키워드] Activation Antiviral assist binding cascade cell damage cell membrane components COVID-19 COVID-19 infection Cytokines Defense downregulate drug expression facilitate food help highlight host cells immune immune signature immune system in viral Infection Inflammation inflammatory chemokine Inflammatory response innate immune response innate immune system interfere intracellular signaling involved ligands mechanism mediation modulate molecular pathogen invasion pathogenic Protein recognizing responsible RNA SARS-CoV-2 signaling pathway therapeutic agent Therapeutic approach TLR TLR agonists TLRs Toll-like receptor type 1 interferon [DOI] 10.3390/ijms231810716 PMC 바로가기
Individual genetic variability mainly of Proinflammatory cytokines, cytokine receptors, and toll-like receptors dictates pathophysiology of COVID-19 disease주로 전염증성 사이토카인, 사이토카인 수용체 및 톨 유사 수용체의 개별 유전적 다양성이 COVID-19 질병의 병태생리를 좌우합니다Review Published on 2022-09-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, [키워드] acquired immunity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Alter B cells chemokine chemokines Clinical outcome clinical outcomes coding gene coding genes condition coronavirus coronavirus disease Coronavirus disease-19 Coronavirus-2 COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 severity cytokine Cytokine storm Cytokines determine exacerbate Gene Expression genes encoding Genetic genetic variability Genetic variation Genetic variations Host IL10 IL17 IL4 IL6 IL7 immune immune response immune responses Immunity individual Infection Inflammation Innate interferons Monocytes Mutation natural killer cell Natural killer cells Neutrophils nucleotide pathophysiology Patient polymorphism proinflammatory cytokines receptors respiratory symptoms response SARS-COV-2 infection Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe respiratory symptoms severity of COVID-19 Single nucleotide polymorphism single nucleotide polymorphisms SNP SNPs susceptibility T cells the patient TLR TLR3 TLR7 TLR9 TLRs TNF Toll-like receptor Toll-like receptors understanding variants of concern Variation viral infection viral infections VOCs [DOI] 10.1002/jmv.27849 PMC 바로가기 [Article Type] Review
Nanoparticle-delivered TLR4 and RIG-I agonists enhance immune response to SARS-CoV-2 subunit vaccine나노입자 전달 TLR4 및 RIG-I 작용제는 SARS-CoV-2 소단위 백신에 대한 면역 반응을 향상시킵니다Article Published on 2022-07-012022-09-11 Journal: Journal of controlled release : official journal o [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] activated Adaptive immune response adjuvant adjuvants agonist Anti-spike anti-Spike IgG Antibody titer Antibody titers Antigen antigen-presenting cell antigen-presenting cells APC APCS B cell B cells BAL Bcl6 Blood bronchoalveolar CD4 CD44 Cell cell population characterized Combination adjuvant COVID-19 COVID-19 protein subunit vaccine CpG DLNs draining lymph node draining lymph nodes Efficacy ENhance follicular Germinal center GL7 helper cell humoral immune responses IgA IgG immune immune response immune responses Immunity IMPROVE in vitro in vivo Increases increases in Infection intramuscular intramuscular vaccination intranasal Intranasal versus intramuscular vaccination intranasally lead lung Lungs lymphocyte memory T memory T cell mice molecular Monophosphoryl lipid A MPLA Native neutralizing antibody titers Pattern recognition pattern recognition receptor Pattern recognition receptors Polymer Population Proinflammatory cytokine Protein subunit protein subunit vaccine Protein subunit vaccines PRR PRRs PUUC reaction receptor receptors responses against retinoic acid retinoic acid-inducible gene I RIG-I robust S1 subunit SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein secretion spike IgA Spike protein stabilized spike protein stimulate subunit Subunit vaccine T cell T cell proliferation the S1 subunit TLR TLR4 TLR7 TLR7/8 TLR9 TLRs Toll-like receptor Toll-like receptors Transmission unique Vaccine vaccine availability vaccine responses variants [DOI] 10.1016/j.jconrel.2022.05.023 PMC 바로가기 [Article Type] Article
Immunoinformatic approach for the construction of multi-epitopes vaccine against omicron COVID-19 variant오미크론 COVID-19 변이체에 대한 다중 에피토프 백신 구축을 위한 면역정보학적 접근Article Published on 2022-07-012022-09-11 Journal: Virology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] added adjuvant antigenic antigenic epitope antigenic epitopes applied approach B cell epitope B cell epitopes B-cell B.1.1.529 CD4 CD8 chimeric Chimeric vaccine model codon optimization complexes computational tool computational tools concern construction country COVID-19 COVID-19 omicron variant effective epitope Epitopes expression Final flexible Health Organization help highly antigenic Host IFN-γ immune mechanism immunogenic in-silico increasingly inducer initiative linker MEV MHC-II molecular molecular docking molecular dynamics mutagenic N-terminal non-allergenic non-toxic omicron Omicron variant overlapping peptide peptide-based planet Protein reverse vaccinology SARS-CoV-2 SARS-CoV-2 infections SARS-CoV-2 variant Scientific community Simulation spike Spike protein stability suggested T-cell T-cell epitopes TLR TLR2 TLR4 TLRs toxic treat unique vaccination Vaccine vaccine candidate variant VoC WHO World Health Organization [DOI] 10.1016/j.virol.2022.05.001 PMC 바로가기 [Article Type] Article