TNFAIP3 – Communicable Diseases Research

A Previously Undiscovered Circular RNA, circTNFAIP3, and Its Role in Coronavirus Replication

Research Article

Published on 2021-11-162022-10-29
Journal: mBio [Category] Coronavirus,

Antiviral and Immunomodulatory Effects of Pelargonium sidoides DC. Root Extract EPs® 7630 in SARS-CoV-2-Infected Human Lung Cells

Pharmacology

Published on 2021-10-252022-10-31
Journal: Frontiers in Pharmacology [Category] COVID-19,

[키워드] accompanied Affect Anti-inflammatory Antiviral antivirals assessment Calu-3 Calu-3 cell candidate CCL5 CD40L cell line cellular entry chemokine clinical study comparable Concentration coronavirus CoV COVID-19 COVID-19 therapeutics CXCL10 CXCL9 cytokine cytokine secretion Cytokine storm derivatives disease drug Duration of infection Effect elevated exhibited Extract fraction growth growth factor highly pathogenic Human human lung IC50 IL-13 IL-1β IL-6 IL-8 IL1B IL6 immune immunomodulatory function immunomodulatory properties in vitro in vivo Inflammatory response inhibited inhibiting innate immune response MERS-CoV modulation non-toxic oligomerization Particle PDGF Pelargonium pelargonium root extract (EPs® 7630) Phytomedicine Post-infection pro-inflammatory cytokine pro-inflammatory gene Prodelphinidin pseudovirus purine reduced reducing Regulation root SARS-CoV SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 propagation separated shown significantly symptom severity TNF-α TNFAIP3 upper respiratory upregulation Viral load viruses
[DOI] 10.3389/fphar.2021.757666 PMC 바로가기 [Article Type] Pharmacology

SARS-CoV-2 early infection signature identified potential key infection mechanisms and drug targets

SARS-CoV-2 조기 감염 시그니처는 잠재적인 주요 감염 메커니즘 및 약물 표적 식별

Research Article

Published on 2021-02-182022-09-10
Journal: BMC Genomics [Category] MERS, 신약개발, 유전자 메커니즘,

[키워드] addition antidepressants association atorvastatin BALF BALF cells bimodal biopsies Bronchoalveolar lavage fluid Bronchoalveolar lavage fluid cells candidate Candidates caused Cell characterized COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 outbreak COVID-19 treatments cultured cell cultured cells database dataset deaths Differential gene expression disease drug drug target early infection effective Efficacy expression profile Gene Expression gene signature HDAC healthy healthy and infected patients highlighting ibuprofen identify IFIT2 Immune cell immune cells infected patient infected with SARS-CoV-2 Infection infection mechanism inhibitors investigated ketoconazole lung lung biopsies mechanism moderate mononuclear cell mononuclear cells Mortality NFKBIA PBMC PBMCs Peripheral blood Peripheral blood mononuclear cells PPP1R15A Previous studies previous study public health Result robust safety profile SARS-CoV-2 SARS-CoV-2 gene expression signature SARS-COV-2 infection Sequencing severely infected patient severely infected patients severity shown signature single-cell supplementary material the disease the SARS-CoV-2 therapy TNFAIP3 transcriptional activity treating SARS-CoV-2 infection Treatment Vaccine
[DOI] 10.1186/s12864-021-07433-4 PMC 바로가기 [Article Type] Research Article

COVID‐19, varying genetic resistance to viral disease and immune tolerance checkpoints

코로나19, 바이러스성 질병에 대한 다양한 유전적 저항성과 면역관용 체크포인트

Review

Published on 2020-11-232022-09-10
Journal: Immunology and Cell Biology [Category] Fulltext, MERS, SARS, 유전자 메커니즘, 조류인플루엔자, 진단,

[키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive adaptive immune responses America antibody Antibody responses Asymptomatic CD8 T cell CD8 T cells cGAS colonization core coronavirus coronavirus disease Coronavirus disease 2019 COVID‐19 cowpox crisis CTLA‐4 difference Genes Genetic genetic mechanism genetic resistance genomic technology Human immunodeficiency virus immune immune responses immune tolerance Infection Influenza interferon knowledge lethal limit MARK mechanism myxoma neutralizing antibody responses outcome pandemic parameter pathology PD‐1 plague problem problems pyroptosis respiratory responsible SARS‐CoV‐2 severe acute respiratory syndrome Coronavirus smallpox T cells threshold TNFAIP3 Tolerance Vaccine Viral viral disease virus virus transmission viruses zoonose zoonoses zoonosis
[DOI] 10.1111/imcb.12419 PMC 바로가기 [Article Type] Review

The NF-κB-dependent and -independent transcriptome and chromatin landscapes of human coronavirus 229E-infected cells

Research Article

Published on 2017-03-292022-10-29
Journal: PLoS Pathogens [Category] Coronavirus, MERS,

[키워드] A20 A549 activated acute respiratory distress adjust approach ARDS attenuate Cell cells cellular change characterized chromatin combinations Complete Concentration contribute coronavirus coronavirus-infected cells correlated cytoplasm cytoplasmic de novo gene Degradation enhancer enhancer region Epigenetic event example expected expression expression level expression of gene Factor fine-tune Gene Expression Genes genes encoding Genome genome-wide investigation genomic region HCoV-229E HKU1 Host host cell host cell cytoplasm host response human coronavirus 229E humans identify IKK IKKβ IL-1 immunomodulatory factor immunomodulatory function infected cell infections Inflammatory Inflammatory cytokine involved IκBα Lung disease mechanism mechanisms MERS-CoV metabolic processes Modification molecular molecular basis motif NEMO NF-κB NF-κB signaling NL63 nuclear nuclear chromatin nucleus OC43 p65 pathogenic Pathogens pathology promote promoter Protein provide recruited recruitment regulatory region Replication required restrict RNA Polymerase II RNA virus SARS-CoV second shown Signaling subunit syndrome These cells TNFAIP3 transcribed Transcription transcription factor Transcriptome Treatment Trigger upper respiratory tract upregulated gene upregulation variety viral replication virus virus replication Virus-host interactions Zoonotic coronavirus
[DOI] 10.1371/journal.ppat.1006286 PMC 바로가기 [Article Type] Research Article