The accurate diagnosis for COVID-19 variants using nearly initial-rough setsResearch Article Published on 2024-05-172024-09-05 Journal: Heliyon [Category] update2024, [키워드] 54A10 68U01 68U35 68W25 92C50 COVID-19 Initial-neighborhoods Nearly open sets Rough sets Topology [DOI] 10.1016/j.heliyon.2024.e31288 PMC 바로가기 [Article Type] Research Article
Small-molecule screening identifies Syk kinase inhibition and rutaecarpine as modulators of macrophage training and SARS-CoV-2 infectionArticle Published on 2022-10-042022-11-16 Journal: Cell Reports [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome chromosomal Compound coronavirus Coronavirus infection CP: Immunology Effect Effects highlighting human macrophages identify induce influenza A inhibit inhibitor innate immune innate immune training LPS LPS tolerance Macrophage memory modulate modulation Necrosis NFAT-2 OC43 pro-inflammatory cytokine pro-inflammatory cytokines promote promoter prophylactic treatment reported rutaecarpine. SARS-CoV-2 SARS-COV-2 infection secretion small molecule susceptibility Syk inhibition TNF Tolerance Topology variant [DOI] 10.1016/j.celrep.2022.111441 PMC 바로가기
Antigenic cartography of SARS-CoV-2 reveals that Omicron BA.1 and BA.2 are antigenically distinctArticle Published on 2022-09-232022-11-15 Journal: Science Immunology [Category] SARS, 변종, 진단, [키워드] Affect antigenic Antisera Beta booster Calu-3 Calu-3 cell cell line Characteristics Cluster Clustering Delta Efficacy Gamma Genetic human airway Map Neutralization assay not affect omicron outliers Primary infection replacing reveal SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sequence spike mutations Spread Topology Vaccine vaccine-induced antibody response Vaccines variant viruses [DOI] 10.1126/sciimmunol.abq4450 PMC 바로가기
Blood gene expression predicts intensive care unit admission in hospitalised patients with COVID-19Article Published on 2022-09-202022-11-16 Journal: Frontiers in Immunology [Category] 유전자 메커니즘, [키워드] activated Admission Alpha Biomarkers Blood Cohort COVID-19 COVID-19 pandemic Critical care defined EGFR epidermal expression First wave Gene Expression gene expression signature gene signature growth factor healthcare Healthcare system hospital hospitalised hospitalised patient ICU admission individual information intensive care intensive care unit naïve outcomes pathway Patient patients with COVID-19 peroxisome predict predicted Predictive Prognosis prognostic receptor resource RNA RNA sequencing RNA-Seq RNA-seq - RNA sequencing ROC tested TGF-β topological data analysis Topology Transcriptome transforming growth factor Treatment was measured Whole blood with COVID-19 [DOI] 10.3389/fimmu.2022.988685 PMC 바로가기
AIRRscape: An interactive tool for exploring B-cell receptor repertoires and antibody responsesArticle Published on 2022-09-202022-11-15 Journal: PLoS Computational Biology [Category] SARS, 진단, [키워드] antibody antibody repertoire Antibody Response antibody sequence B-cell BCR browser CDR3 comparison Coverage dataset dengue virus Exploratory analyses Github HIV-1 Humoral immunity immune Immunoglobulin monoclonal antibody motif Pathogens Patient receptor repertoire responses reveal SARS-CoV-2 selected sequence Sequencing subset Topology Vaccine [DOI] 10.1371/journal.pcbi.1010052 PMC 바로가기
Integrated bioinformatics-cheminformatics approach toward locating pseudo-potential antiviral marine alkaloids against SARS-CoV-2-MproSARS-CoV-2-Mpro에 대한 유사 잠재적 항바이러스 해양 알칼로이드를 찾기 위한 통합 생물정보학-화학정보학 접근Article Published on 2022-09-012022-09-11 Journal: Proteins [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 added Alpha analyzed Antiviral antiviral marine alkaloids approach ATB AutoDock B.1.1.529 B.1.1.7 B.1.351 B.1.617.2 Beta binding energy candidate carried complex complexes contagious Coronavirus-2 darunavir docking docking study drug drug-likeness drug-likeness profiles prediction Entropy enzyme exhibit free energy H-bond highest Initially investigated Ligand literature review Lopinavir lowest MD simulation MM/PBSA molecular molecular docking molecular docking simulation molecular dynamics Molecular mechanics Molecular Orbital morbidity morbidity and mortality MPro omicron pharmacokinetics pharmacological physicochemical predicted profile profiles protease Protein Protein Data Bank retrieved RMSD RMSF SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 main protease selected Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2-Mpro. surface area thermodynamic Topology Toxicity variants Virtual screening were assessed were recorded [DOI] 10.1002/prot.26341 PMC 바로가기 [Article Type] Article
SEMgsa: topology-based pathway enrichment analysis with structural equation modelsSEMgsa: 구조 방정식 모델을 사용한 토폴로지 기반 경로 강화 분석Article Published on 2022-08-172022-09-11 Journal: BMC Bioinformatics [Category] 유전자 메커니즘, [키워드] Activation Algorithm coronavirus disease COVID-19 dataset disease DNA methylation dysregulation enrichment enrichment analysis estimate evaluate expression data followed by framework frontotemporal dementia functional Gene Expression generate Genes GEO identify information mechanism metabolites node novel pathway Pathway enrichment analysis Pathway topology Pathways power prioritization Protein R package RNA-seq dataset SEM SEMgsa sensitivity Simulation specific disease Statistical power statistically subset text Topology type I type I error Type I error. were used [DOI] 10.1186/s12859-022-04884-8 PMC 바로가기 [Article Type] Article
Potential Material Basis of Yupingfeng Powder for the Prevention and Treatment of 2019 Novel Coronavirus Pneumonia: A Study Involving Molecular Docking and Molecular Dynamic Simulation Technology2019년 신종 코로나바이러스 폐렴의 예방 및 치료를 위한 Yupingfeng 분말의 잠재적 재료 기반: 분자 도킹 및 분자 동적 시뮬레이션 기술 관련 연구Article Published on 2022-06-242022-09-11 Journal: BioMed Research International [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] 2019 novel coronavirus 2019 novel coronavirus pneumonia Algorithm Analysis analyzed AutoDock Basis binding Chinese common disease complexes component Coronavirus pneumonia Cytoscape software database disease DisGeNET docking dynamic enrichment analysis free energy Free energy calculation Free energy calculations Gene ontology GeneCard generate HIF-1 hydrogen Hydrogen bond identify ingredient Interaction investigated Involving KEGG pathway MAPK material mechanism molecular molecular docking molecular dynamic simulations novel Novel coronavirus novel coronavirus pneumonia Pathways performed Pneumonia Potential potential mechanism powder predict Predictive prevention protease Protein protein-protein interaction receptor retrieved SARS-CoV-2 selected Simulation STRING database T cell T cell receptor target target gene Target genes TCMSP technology TNF Toll-like receptor Topology Traditional Chinese medicine Treatment VEGF VEGF signaling was used were used [DOI] 10.1155/2022/7892397 PMC 바로가기 [Article Type] Article
Multivalent 9-O-Acetylated-sialic acid glycoclusters as potent inhibitors for SARS-CoV-2 infectionSARS-CoV-2 감염에 대한 강력한 억제제로서의 다가 9-O-아세틸화-시알산 글리코클러스터Article Published on 2022-05-102022-09-11 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] affinity angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Angiotensin-converting enzyme 2 receptor Anti-viral atomic bind binding Cell develop event Factor glycans Host host cell Infection inhibition Inhibition assays inhibitor Microscopy moderate molecular multivalent Perspective receptor residues SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant sialic acid therapeutic purpose therapeutic purposes Topology Treatment virus while [DOI] 10.1038/s41467-022-30313-8 PMC 바로가기 [Article Type] Article
Quantifying agent impacts on contact sequences in social interactionsArticle Published on 2022-03-032022-10-29 Journal: Scientific Reports [Category] Coronavirus, MERS, SARS, [키워드] applied collected Complex networks Contact determine effective highlight Human Human behaviour Impact individual individuals Interaction interactions Metrics pathogen SARS-CoV-2 sequence social interaction Spread temporal variability Topology Transmission [DOI] 10.1038/s41598-022-07384-0 PMC 바로가기 [Article Type] Article