Finding a Mentor While “Storm” Chasing with Howard YoungArticle Published on 2022-12-012023-07-10 Journal: Journal of interferon & cytokine research : the of [Category] COVID19(2023년), [키워드] cytokine Cytokine storm Howard Young immunologist interferon mentorship Sepsis Toxic shock syndrome [DOI] 10.1089/jir.2022.0157
Multisystem Inflammatory Syndrome in Children and Long COVID: The SARS-CoV-2 Viral Superantigen Hypothesis소아 및 장기 코로나의 다기관 염증 증후군: SARS-CoV-2 바이러스 초항원 가설Article Published on 2022-07-072022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료기술, [키워드] addition Alter attribute autoantibodies autoantibody autoimmune responses Autoimmunity Bacterial binding Cell change children children with MIS-C circulating computational studies conjunctivitis conserved contribute COVID COVID-19 develop elevated exposure to feature febrile Fever Gastrointestinal glycoprotein Gut high affinity hyperinflammation immune response Immunosequencing Inflammatory inflammatory disease initial Kawasaki disease Long Long COVID MHC class II MHC Class II proteins MIS-C MIS-C multisystem inflammatory syndrome in children motif Multiorgan Neurological complication Neurological complications Neurological symptom Neurological symptoms neuronal neurotoxin neurotoxin-like segment oral mucosa PASC Patient patients pediatric Peripheral blood peripheral blood samples persistence persistent fever Post-acute sequelae of COVID-19 (PASC) prolonged exposure promote Proteins rashes resulting SAgs SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA SARS-CoV-2 spike SARS-CoV-2 virus SEB Sequence analysis serum cytokine levels severity Shock similarity staphylococcal enterotoxin staphylococcal enterotoxin B strawberry strawberry tongue Structure superantigen superantigen-like motif. syndrome systemic hyperinflammation T-cell receptor TCR TCRs the SARS-CoV-2 the SARS-CoV-2 virus Toxic shock Toxic shock syndrome TRBV11-2 triggered TSS unique β variable [DOI] 10.3389/fimmu.2022.941009 PMC 바로가기 [Article Type] Article
Multisystem Inflammatory Syndrome in Children: Unique Disease or Part of the Kawasaki Disease Spectrum?Pediatrics Published on 2021-06-042022-10-31 Journal: Frontiers in Pediatrics [Category] COVID-19, [키워드] abdominal pain administration children clinical feature conditions COVID-19 COVID-19 pandemic develop diarrhea Disease spectrum Evidence favor glucocorticoid Hypothesis illness Inflammatory instances Interpretation Intravenous immunoglobulin Kawasaki disease less macrophage activation syndrome MIS-C multiorgan failure multisystem inflammatory syndrome in children myocardial involvement myocarditis Occurrence overlapping Part Patient SARS-CoV-2 Shock Symptom syndrome Toxic shock syndrome [DOI] 10.3389/fped.2021.680813 PMC 바로가기 [Article Type] Pediatrics
A fatal toxic shock-like syndrome post COVID-19 infection in a child어린이의 COVID-19 감염 후 치명적인 독성 쇼크 유사 증후군Case Reports Published on 2021-06-022022-09-10 Journal: Italian Journal of Pediatrics [Category] MERS, 바이오마커, [키워드] abdominal pain affected Cardiac output catecholamine Child children condition coronavirus disease Coronavirus disease 2019 Coronavirus infection Corticosteroid COVID-19 COVID-19 infection Definition echocardiography Ejection Ejection fraction Fever fresh frozen plasma frozen plasma heart failure High dose Hypotension Immunoglobulin Inflammatory inflammatory markers intensive care Intravenous immunoglobulin Kawasaki disease lesions life-threatening lymphopenia Manifestations MIS-C Multi-system inflammatory syndrome multiple organ dysfunction multiple organ failure organ dysfunction outcome Patient pediatric pericardial effusion persistent fever plasma presenting receiving SARS-COV-2 infection Severe case severe cases Shock Symptom syndrome Toxic shock syndrome TSS: toxic shock syndrome valvular Vasopressor vasopressors [DOI] 10.1186/s13052-021-01070-z PMC 바로가기 [Article Type] Case Reports
HLA class I-associated expansion of TRBV11-2 T cells in multisystem inflammatory syndrome in children어린이의 다기관 염증 증후군에서 TRBV11-2 T 세포의 HLA 클래스 I 관련 확장Article Published on 2021-05-172022-09-11 Journal: The Journal of Clinical Investigation [Category] SARS, 유전자 메커니즘, [키워드] Activation allele Antigen Bacterial CDR3 characterized children clinical feature Clinical features clone complementarity-determining region correlated COVID-19 distribution HLA HLA class I HLA class I alleles Hyperinflammatory syndrome immunology indicated Inflammatory Interaction mechanism MIS-C motif Patient residue SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 spike glycoprotein serum cytokine levels severity Shock specificity spike glycoprotein superantigen syndrome T cell T cell receptor T cells TCR Toxic shock Toxic shock syndrome TRBV11-2 triggered [DOI] 10.1172/JCI146614 PMC 바로가기 [Article Type] Article
Toxic shock syndrome with a cytokine storm caused by Staphylococcus simulans : a case report스태필로코쿠스 시뮬란스에 의한 사이토카인 폭풍을 동반한 독성 쇼크 증후군: 사례 보고Case Report Published on 2021-01-062024-07-30 Journal: BMC Infectious Diseases [Category] 폐렴구균 감염증, [키워드] Coagulase-negative staphylococcus Cytokine storm Staphylococcus simulans Toxic shock syndrome [DOI] 10.1186/s12879-020-05731-y PMC 바로가기 [Article Type] Case Report
Correlation between takotsubo cardiomyopathy and SARS-CoV-2 infectionReview Published on 2021-01-012023-07-13 Journal: Med Hypotheses [Category] SARS, [키워드] COVID-19 Kawasaki disease SARS-CoV-2 Takotsubo cardiomyopathy Toxic shock syndrome [DOI] 10.1016/j.mehy.2020.110454 PMC 바로가기 [Article Type] Review
Severe manifestations of SARS-CoV-2 in children and adolescents: from COVID-19 pneumonia to multisystem inflammatory syndrome: a multicentre study in pediatric intensive care units in SpainResearch Published on 2020-11-262022-11-01 Journal: Critical Care [Category] COVID-19, SARS, [키워드] C-reactive protein carried Characteristics children clinical collected Corticosteroid COVID-19 criteria Critical care Critically ill described diarrhea discharged distress dysfunction fatigue feature Fever Gastrointestinal symptom had no healthy Immunoglobulin immunomodulator Inflammatory intensive care unit invasive ventilation IQR Kawasaki disease Laboratory LDH less Lymphocyte count manifestation mechanical ventilation median MIS-C Most patient multicentre National neutrophil count Older Patient patients patients died pediatric Pediatric multisystem inflammatory syndrome temporally associated with COVID-19 Pneumonia presenting Prevalence procalcitonin proportion receive recruited Result SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 PCR Shock Spain syndrome therapeutic Toxic shock syndrome treated vasoactive drug vomit with COVID-19 [DOI] 10.1186/s13054-020-03332-4 PMC 바로가기 [Article Type] Research
Multisystem Inflammatory Syndrome in Children, the Real Disease of COVID-19 in Pediatrics – A Multicenter Case Series From Al-Ahsa, Saudi ArabiaPediatrics Published on 2020-10-202022-10-31 Journal: Cureus [Category] COVID-19, [키워드] Care children coronavirus disease Course COVID-19 develop disease disease entity exhibit Fever GI symptoms Health identify Infection Inflammatory Kawasaki Mild MIS-C msi-c Patient pediatric pediatrics Population risk factor Saudi Arabia Sery syndrome systemic inflammatory response Toxic shock syndrome [DOI] 10.7759/cureus.11064 PMC 바로가기 [Article Type] Pediatrics
Superantigenic character of an insert unique to SARS-CoV-2 spike supported by skewed TCR repertoire in patients with hyperinflammation530 Published on 2020-10-132022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, MERS, SARS, [키워드] Activation acute respiratory syndrome Adaptive immune response adaptive immune system adult COVID-19 patient adult COVID-19 patients Bacterial binding binding epitope caused children complex coronavirus Coronaviruses COVID-19 COVID-19 patient Cytokine storm disease Escalation European Excessive activation exhibit explain glycoprotein histocompatibility complex hyperinflammation Hyperinflammatory Hyperinflammatory syndrome implication include Infection Interaction intercellular MHCII MIS-C motif Mutation Pandemics pathogenic Patient residue SARS virus SARS-CoV-2 SARS-CoV-2 S SARS-CoV-2 spike SARS-related coronaviruses selected sequence severe COVID-19 patients Shock Significance skewed staphylococcal superantigen Support supported Symptom syndrome T cell T cell receptor T cell receptors TCR TCR binding TCRs the cytokine storm the receptor-binding domain the SARS-CoV-2 therapeutic approaches Toxic shock syndrome triggered TSS unique virus with COVID-19 [DOI] 10.1073/pnas.2010722117 PMC 바로가기 [Article Type] 530