Investigation of the Effect of Hafnium Chloride on Sperm Viability and Motility in Normospermic Cases: An In Vitro StudyOther Published on 2024-06-102024-09-05 Journal: Cureus [Category] update2024, [키워드] hafnium chloride Semen analysis sperm motility sperm viability toxicology [DOI] 10.7759/cureus.62084 PMC 바로가기 [Article Type] Other
Hepatitis A Virus Infection in Cynomolgus Monkeys Confounds the Safety Evaluation of a Drug CandidateOriginal Article Published on 2024-03-192024-09-05 Journal: International Journal of Toxicology [Category] update2024, [키워드] cynomolgus monkey Drug development hepatic pathology hepatitis A virus hepatotoxicity non-human primate safety evaluation toxicology [DOI] 10.1177/10915818241237992 PMC 바로가기 [Article Type] Original Article
Clinical formulation development of Plasmodium falciparum malaria vaccine candidates based on Pfs48/45, Pfs230, and PfCSPArticle Published on 2024-03-192024-08-29 Journal: Vaccine [Category] 말라리아, [키워드] Drug Product Formulation malaria Manufacture toxicology Vaccine [DOI] 10.1016/j.vaccine.2024.02.043
Armeniacae semen amarum : a review on its botany, phytochemistry, pharmacology, clinical application, toxicology and pharmacokineticsPharmacology Review Published on 2024-01-232024-09-05 Journal: Frontiers in Pharmacology [Category] update2024, [키워드] Armeniacae semen amarum Clinical application ethnopharmacology Pharmacology phytochemistry Prunus armeniaca L. toxicology Traditional Chinese medicine [DOI] 10.3389/fphar.2024.1290888 PMC 바로가기 [Article Type] Pharmacology Review
The NIH Comparative Genomics Resource: addressing the promises and challenges of comparative genomics on human healtharticle Published on 2023-09-272024-09-05 Journal: BMC Genomics [Category] update2024, [키워드] annotation bioinformatics human health Microbiome NIH Comparative Genomics Resource (CGR) oncology Sequence contamination toxicology xenotransplantation zoonotic disease [DOI] 10.1186/s12864-023-09643-4 PMC 바로가기 [Article Type] article
Generalized Tetanus with Opisthotonosarticle Published on 2023-06-302024-09-01 Journal: The Journal of Emergency Medicine [Category] 파상풍, [키워드] Opisthotonos Risus Sardonicus Tetanus toxicology trismus [Article Type] article
Activation of the urotensin-II receptor by remdesivir induces cardiomyocyte dysfunctionarticle Published on 2023-05-122024-09-05 Journal: Communications Biology [Category] update2024, [키워드] cardiovascular diseases Cell signalling Drug safety toxicology [DOI] 10.1038/s42003-023-04888-x PMC 바로가기 [Article Type] article
FDA and industry collaboration: Identifying opportunities to further reduce reliance on nonhuman primates for nonclinical safety evaluationsArticle Published on 2023-02-012023-07-11 Journal: Regulatory toxicology and pharmacology : RTP [Category] COVID19(2023년), [키워드] 3Rs Developmental and reproductive toxicity Nonclinical safety nonhuman primate toxicology Toxicology study designs. [DOI] 10.1016/j.yrtph.2022.105327
Towards understanding respiratory particle transport and deposition in the human respiratory system: Effects of physiological conditions and particle propertiesArticle Published on 2022-10-052023-07-10 Journal: Journal of hazardous materials [Category] COVID19(2023년), [키워드] COVID-19 deposition Fly ash Respiration toxicology [DOI] 10.1016/j.jhazmat.2022.129669 PMC 바로가기
Comprehensive Nonclinical Safety Assessment of Nirmatrelvir Supporting Timely Development of the SARS-COV-2 Antiviral Therapeutic, Paxlovid™SARS-COV-2 항바이러스 치료제 Paxlovid™의 적시 개발을 지원하는 Nirmatrelvir의 포괄적인 비임상 안전성 평가Article Published on 2022-08-012022-09-11 Journal: International journal of toxicology [Category] 치료제, [키워드] 3CL administration Antiviral Arrhythmias assessment blood pressure cardiovascular caused clinical development Clinical pathology coagulation time Comprehensive conducted COVID-19 COVID-19 patient COVID-19 patients death decrease decreases development dose Drug safety Effect Efficacy Endpoint enhancer enzyme functional heart rate high risk highest dose Hospitalization Increases increases in induce Infection locomotor male MPro nervous system Nirmatrelvir not affect pathology Paxlovid pharmacokinetic Potential produced profile protease RATs Replication respiratory rate Ritonavir Safety safety pharmacology SARS-CoV-2 SARS-CoV-2 virus Support Supporting target tested the SARS-CoV-2 virus toxicities Toxicity toxicology transaminase transaminases Treatment treatment of COVID-19 were assessed [DOI] 10.1177/10915818221095489 PMC 바로가기 [Article Type] Article