[Virtual screening of active ingredients of traditional Chinese medicine in treating COVID-19 based on molecular docking and molecular dynamic simulation]Article Published on 2022-10-252023-07-10 Journal: Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = [Category] COVID19(2023년), [키워드] COVID-19 molecular docking molecular dynamics simulations traditional Chinese medicines Virtual screening Xambioona. [DOI] 10.7507/1001-5515.202205021 PMC 바로가기
The regulation of ISG20 expression on SARS-CoV-2 infection in cancer patients and healthy individualsArticle Published on 2022-09-132022-11-15 Journal: Frontiers in Immunology [Category] SARS, 변종, 치료제, [키워드] analyzed anti-SARS-CoV-2 anticancer Bone marrow Cancer cancer cell cancer cell lines cancer patient Cancer patients chemokine combating cordycepin cordycepin (CD). correlated COVID-19 COVID-19 pandemic domain exhibited expression functional healthy healthy individual highest immune Immune cell infiltration immune infiltration individuals information inhibit Invasion ISG20 ISG20 expression isoform less Lymphocytes lymphoid tissues marker Methylation MHC molecule mRNA expression mutant N6 N6-dimethyladenosine (m 6 2A) outcome overexpression promoter receptors Regulation SARS-CoV-2 SARS-COV-2 infection significantly significantly increased significantly lower small molecule survival survival rate susceptibility the median therapeutic potential tissue tissues traditional Chinese medicines treat tumorigenesis underlie virus were used [DOI] 10.3389/fimmu.2022.958898 PMC 바로가기
Efficient discovery of potential inhibitors for SARS-CoV-2 3C-like protease from herbal extracts using a native MS-based affinity-selection method천연 MS 기반 친화성 선택 방법을 사용하여 허브 추출물에서 SARS-CoV-2 3C 유사 프로테아제에 대한 잠재적 억제제의 효율적인 발견Article Published on 2022-02-052022-09-11 Journal: Journal of pharmaceutical and biomedical analysis [Category] COVID19(2023년), SARS, 치료제, [키워드] 3CL 3CL Protease 3CLpro acquisition acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 applied baicalein binding affinity characterized China Cirsium Complexes Compound compounds conducted Coronaviral coronavirus COVID-19 COVID-19 therapy Data acquisition Data processing Effectiveness efficient effort flavonoids Forsythia fraction Fractions Glycyrrhiza uralensis identify incubated Infection inhibitor investigated life cycle Ligand Lonicera japonica Native Native MS natural natural product outcomes protease protein-ligand resources SARS-CoV-2 scutellarein Scutellaria baicalensis severe acute respiratory syndrome Coronavirus small molecule Standard TCM therapy Traditional Chinese medicine traditional Chinese medicine. traditional Chinese medicines Treatment UHPLC Virus life cycle were used [DOI] 10.1016/j.jpba.2021.114538 PMC 바로가기 [Article Type] Article
Natural biflavones are potent inhibitors against SARS-CoV-2 papain-like protease천연 비플라본은 SARS-CoV-2 파파인 유사 프로테아제에 대한 강력한 억제제입니다Article Published on 2022-01-012022-09-11 Journal: Phytochemistry [Category] SARS, 치료제, [키워드] Antiviral antiviral immunity cleavage compounds COVID-19 COVID-19 treatment deISGylation. demonstrated effective enzyme exhibited immune evasion in viral inhibitor inhibitors of SARS-CoV-2 inhibitory effect involved molecular docking National natural Natural biflavone nine Papain Papain-like protease promotion protease SARS-CoV-2 Significant Traditional Chinese medicine traditional Chinese medicines Treatment Viral immune evasion viral replication viral spread Virtual screening [DOI] 10.1016/j.phytochem.2021.112984 PMC 바로가기 [Article Type] Article
Combined drug repurposing and virtual screening strategies with molecular dynamics simulation identified potent inhibitors for SARS-CoV-2 main protease (3CLpro)분자 역학 시뮬레이션과 결합 된 약물 재검사 및 가상 스크리닝 전략 SARS-COV-2 주요 프로테아제 (3CLPRO)에 대한 강력한 억제제를 확인했습니다.Article Published on 2021-08-012022-08-31 Journal: Journal of biomolecular structure & dynamics [Category] MERS, SARS, 신약개발, [키워드] 3CLpro accelerate anti-HIV drugs approach approved binding binding free energy Care catalytic dyad Combined confirmed case coronavirus Cys145 database death disease dissemination drug Drug screening drug-repurposing Epidemic FDA FIVE free energy Health care Health care system His41 HIV idea in viral infection rate inhibit inhibitor inhibitors intensity maturation molecular dynamics Molecular dynamics simulation pandemic pathway protease public health raised Replication reported Research saquinavir SARS-CoV-2 SARS-CoV-2 main protease screened spread to TCM tested these compound these compounds Traditional Chinese medicine traditional Chinese medicines Vaccine Viral Virtual screening virtual screening. [DOI] 10.1080/07391102.2020.1779128 PMC 바로가기 [Article Type] Article
Multidimensional Evaluation of All-Cause Mortality Risk and Survival Analysis for Hospitalized Patients with COVID-19Research Paper Published on 2021-06-262022-10-29 Journal: International Journal of Medical Sciences [Category] COVID-19, MERS, [키워드] activated acute respiratory distress alanine aminotransferase analyzed Antibiotic therapy Antibiotics Aspartate aminotransferase biochemical markers Brain cause caused Characteristics clinical Clinical characteristics collected Comorbidities Complication complications Computed tomography consolidation Coronavirus disease 2019 correlated COVID-19 COVID-19 patient creatinine Critical D-dimer death Deceased died distress Dyspnea enrolled Glucocorticoid treatment Glucose help Hospital admission inflammatory indicator intravenous Invasive mechanical ventilation investigated Laboratory lesion lung lymphocytopenia male median time medical record medication mortality risk Most patient multiple organ dysfunction Older outcome Patient patients patients with comorbidity patients with COVID-19 peptide proportion Prothrombin time quantified recovered patient recovered patients reduce mortality Respiratory failure Retrospective study risk factor Septic shock shown significantly significantly higher survival survival analysis syndrome Traditional Chinese medicine traditional Chinese medicines Treatment urea Volume with COVID-19 [DOI] 10.7150/ijms.58889 PMC 바로가기 [Article Type] Research Paper
Traditional Herbal Medicines, Bioactive Metabolites, and Plant Products Against COVID-19: Update on Clinical Trials and Mechanism of ActionsPharmacology Published on 2021-05-282022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] Action affecting Against Anti-COVID-19 Anti-infective anticancer therapies Antiviral antiviral properties approach approved Ayurved medicine bioactive metabolites clinical clinical trial conducted coronavirus COVID-19 develop drugs effective Efficacy eliminated global public health Herbal Hospitalization identify infective medications Medicine Medicines metabolite morbidity and mortality notable nutraceuticals pandemic phytochemicals Phytomedicine plant product reached researcher SARS-CoV-2 shown therapy Traditional Traditional Chinese medicine traditional Chinese medicines Vaccine Vaccines viral infection World Health Organization worldwide pandemic [DOI] 10.3389/fphar.2021.671498 PMC 바로가기 [Article Type] Pharmacology
Screening and evaluation of anti-SARS-CoV-2 components from Ephedra sinica by ACE2/CMC-HPLC-IT-TOF-MS approachACE2/CMC-HPLC-IT-TOF-MS 접근법에 의한 Ephedra sinica의 anti-SARS-CoV-2 성분 스크리닝 및 평가Article Published on 2021-05-012022-08-31 Journal: Analytical and bioanalytical chemistry [Category] MERS, SARS, 치료제, [키워드] ACE2 ACE2 receptor Amino acid amino acid residues anti-SARS-CoV-2 approach binding binding assay Binding assays blocker blockers CCK-8 Cell Cell membrane chromatography cells Characteristics China Chinese component Compound compound screening compounds COVID-19 Ephedra sinica Ephedra sinica. ephedrine evaluate feature fraction HPLC inhibit inhibiting Medicine membrane methylephedrine molecular docking observé performed pseudoephedrine pseudovirus reduce SARS-CoV-2 SARS-CoV-2 pseudovirus SARS-CoV-2 spike screened Screening separated SPR staining surface plasmon surface plasmon resonance Toxicity Traditional Traditional Chinese medicine traditional Chinese medicines treat Treatment treatment of COVID-19 viropexis [DOI] 10.1007/s00216-021-03233-7 PMC 바로가기 [Article Type] Article
COVID-19 Pandemic: Epidemiology, Etiology, Conventional and Non-Conventional TherapiesReview Published on 2020-11-042022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] alleviate angiotensin-converting enzyme-2 Anti-viral anticipated arrhythmia beta-coronavirus bind binding cause caused Cell chest pain China Chinese concerning Conventional coronavirus Coronavirus disease 2019 coughing country COVID-19 COVID-19 virus death disease drug drugs Efficacy Epidemiology fatigue Fever highlight Host host cells immune response immune responses include induce Infection Intervention knowledge lack management manifestation mechanism medication Medicine Middle East nausea organism outbreak Protein recorded Remdesivir reported Research respiratory respiratory stress severe COVID-19 severity Shock shown Symptom syndrome TCM the disease the SARS-CoV-2 virus Traditional traditional Chinese medicines Transmission Treatment Vaccine virus Wuhan [DOI] 10.3390/ijerph17218155 PMC 바로가기 [Article Type] Review
Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredientsArticle Published on 2020-07-312023-07-01 Journal: Acta pharmacologica Sinica [Category] SARS, [키워드] 3CL Protease baicalein baicalin SARS-CoV-2 Shuanghuanglian oral liquid traditional Chinese medicines [DOI] 10.1038/s41401-020-0483-6 PMC 바로가기 [Article Type] Article