COVID-19 after two years: trajectories of different components of mental health in the Spanish populationarticle Published on 2023-04-172024-09-05 Journal: Epidemiology and Psychiatric Sciences [Category] update2024, [키워드] COVID-19 growth mixture models mental health Trajectories [DOI] 10.1017/S2045796023000136 PMC 바로가기 [Article Type] article
Deep mutational learning predicts ACE2 binding and antibody escape to combinatorial mutations in the SARS-CoV-2 receptor-binding domainArticle Published on 2022-10-132022-11-15 Journal: Cell [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] ACE2 ACE2 binding antibody antibody treatment artificial intelligence COVID-19 COVID-19 pandemic deep deep learning deep sequencing develop directed evolution domain Evolution of SARS-CoV-2 machine learning mutated variant Mutation mutations Neutralizing antibodies neutralizing antibody omicron predict Predictive Protein protein engineering RBD RBD variants representing SARS-CoV-2 variant Selection sequence the SARS-CoV-2 therapeutic Trajectories Vaccine variant variants viral escape viral spike protein yeast yeast display [DOI] 10.1016/j.cell.2022.08.024 PMC 바로가기
Dynamics of anti-SARS-CoV-2 seroconversion in individual patients and at the population levelArticle Published on 2022-09-092022-11-15 Journal: PLoS ONE [Category] SARS, 진단, 치료기술, 치료제, [키워드] anti-SARS-CoV-2 anti-SARS-CoV-2 IgG antibody antibody production Asymptomatic Care COVID-19 demonstrated determine diagnosed Dynamics fraction Health hidden highest highlighting immune response Immunity individual infected with SARS-CoV-2 Infection key factor levels of antibodies Mild observation occurred pandemic Pandemics participant Patient Perspective Poland population level Population screening positive predict Registered SARS-CoV-2 SARS-COV-2 infection Seroconversion specific antibody suppress Trajectories Vaccinations [DOI] 10.1371/journal.pone.0274095 PMC 바로가기
In silico identification and validation of natural antiviral compounds as potential inhibitors of SARS-CoV-2 methyltransferaseSARS-CoV-2 메틸트랜스퍼라제의 잠재적 억제제로서의 천연 항바이러스 화합물의 실리코(in silico) 식별 및 검증Article Published on 2022-09-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] Coronavirus, SARS, 치료제, [키워드] acute respiratory syndrome coronavirus amentoflavone Analysis analyzed Antiviral agents Antiviral compounds Antiviral natural compounds approach baicalin binding mechanism caused complex Compound coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 treatment Daidzin docking Effect In silico methods indicated inhibit inhibitor inhibitors of SARS-CoV-2 Interaction MD simulation methyltransferase molecular molecular docking molecular dynamic simulation molecular dynamics Molecular dynamics simulation MTase natural antiviral Novel coronavirus novel coronavirus disease offer outbreak parameter Probability resource respiratory SARS-CoV-2 selected severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 stability Substitution the SARS-CoV-2 therapeutic Therapeutics these compound these compounds Trajectories treat Treatment treatment of COVID-19 unavailability vaccination Virtual screening was performed [DOI] 10.1080/07391102.2021.1886174 PMC 바로가기 [Article Type] Article
Inhibition of SARS-CoV-2 main protease: a repurposing study that targets the dimer interface of the proteinSARS-CoV-2 주요 프로테아제의 억제: 단백질의 이량체 계면을 표적으로 하는 용도 변경 연구Article Published on 2022-09-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 신약개발, [키워드] binding energy catalytic dyad catalytically change characterized conformational coronavirus disease coronavirus disease-2019 COVID-19 crystal structure crystal structures Diosmin displaying Drug repurposing DrugBank database elicited eluxadoline Glu166 homodimer inhibition inhibitor inhibitors lethality rate Local M pro main protease modulated molecular molecular dynamics Molecular dynamics simulation molecular dynamics simulations novel target site. pandemic performed positive prominence Prophylaxis protease Protein reported residue SARS-CoV-2 Ser1 Simulation Spread target Therapeutics Trajectories trajectory Treatment Virtual screening Wuhan Wuhan, China Zinc [DOI] 10.1080/07391102.2021.1910571 PMC 바로가기 [Article Type] Article
Improving child health through Big Data and data science Reviews Published on 2022-08-162022-10-05 Journal: Pediatric Research [Category] 바이오마커, [키워드] assessments Characteristics child health childhood children complex creating defined determinant developmental dimension disease risk Diseases fetal for inclusion Genetic Health highlight identify Impact IMPROVE Improving infancy Interaction mechanisms outcomes Patient pediatric phenotype Predictive provide Racial recommendation reducing Regulatory Research resource susceptibility the United State Therapies Trajectories while [DOI] 10.1038/s41390-022-02264-9 [Article Type] Reviews
Phenotypes of disease severity in a cohort of hospitalized COVID-19 patients: Results from the IMPACC studyResearch article Published on 2022-08-092022-10-05 Journal: EBioMedicine [Category] SARS, 바이오마커, 치료기술, [키워드] 7-point ordinal scale 95% CI age antibody assessment association baseline Better characteristics of patient chest imaging Cohort Comorbidities coronavirus disease COVID-19 creatinine death demographics discharge disease course disease severity Dyspnea elevated Factor female finding Follow-up funding Hispanic ethnicity hospital Hospitalization Hospitalized hospitalized COVID-19 Immunophenotyping IMPROVE integration interquartile range Invasive mechanical ventilation Laboratory Logistic regression longitudinal lowest lymphopenia management median age NIH Odds ratio offer outcome overall mortality PASC Patient PCR cycle provide Radiographic required Respiratory illness Result risk factor SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 PCR SARS-CoV2 serology severity Sex survivor Symptom Symptomatic patients The United States threshold Trajectories trajectory Unsupervised clustering Viral load was performed [DOI] 10.1016/j.ebiom.2022.104208 [Article Type] Research article
A ricin-based peptide BRIP from Hordeum vulgare inhibits M pro of SARS-CoV-2Hordeum vulgare의 리신 기반 펩타이드 BRIP는 SARS-CoV-2의 M pro를 억제합니다Article Published on 2022-07-272022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] barley binding binding free energy binding site caused complex component components contributed COVID-19 cytotoxicity domains electrostatic free energy Hordeum identify in vitro inhibit inhibitor inhibitors inhibitory Interaction investigated M pro MD simulations molecular molecular docking molecular dynamics pandemic parameter peptide peptides Research ricin SARS-CoV-2 SARS-CoV-2 main protease stability suggested therapeutic potential thermodynamic Trajectories trajectory Van Van der Waals virus [DOI] 10.1038/s41598-022-15977-y PMC 바로가기 [Article Type] Article
Role of social determinants in anxiety and depression symptoms during COVID-19: A longitudinal study of adults in North Carolina and MassachusettsRandomized Controlled Trial Published on 2022-07-012022-10-05 Journal: Behaviour research and therapy [Category] COVID19(2023년), SARS, 임상, [키워드] Anxiety anxiety symptom anxiety symptoms average baseline Care collected COVID-19 COVID-19 pandemic Depression described determinant evaluate examined Follow-up food insecurity Health implication Massachusett moderate North pandemic participant predict progression Racial/ethnic minorities randomized clinical trial role severe depression social determinant social determinants of health Symptom Trajectories trajectory utility [DOI] 10.1016/j.brat.2022.104102 PMC 바로가기 [Article Type] Randomized Controlled Trial
COVID-19 trajectories among 57 million adults in England: a cohort study using electronic health records영국 성인 5,700만 명 사이의 COVID-19 궤적: 전자 건강 기록을 사용한 코호트 연구Article Published on 2022-07-012022-09-11 Journal: International Journal of Environmental Research an [Category] COVID19(2023년), MERS, SARS, 신약개발, 진단, 치료기술, [키워드] Analysis can be used clinical pathways clinically Cohort cohort study collected COVID-19 COVID-19 phenotype COVID-19 testing COVID-19-related death Data science dataset death death certificate defined diagnose Diagnosis died disease severity disease trajectories disease trajectory EHR eight Electronic health record Electronic health records England estimate event Evidence evidence of FIVE foundation Frequency generate Health Data Research UK heart highest hospital Hospital admission ICU identify incidence individual individuals infection rate intensive care intensive care unit invasive ventilation MONITOR Mortality mortality data National Health Service NHS non-invasive ventilation occurred pandemic Pathways Patient patients Phenotypes positive primary care progression provided recorded remained SARS-CoV-2 test Science secondary care shown Stage stratified study period survival to define Trajectories trajectory vaccination Vaccination Status Ventilation ventilatory support Wave [DOI] 10.1016/S2589-7500(22)00091-7 PMC 바로가기 [Article Type] Article