A Tiny Viral Protein, SARS-CoV-2-ORF7b: Functional Molecular MechanismsArticle Published on 2024-04-302024-09-05 Journal: Biomolecules [Category] update2024, [키워드] cluster analysis co-regulation network COVID-19 interactomics microRNA programmed death SARS-CoV-2 SARS-CoV-2 inter-tissue diffusion SARS-CoV-2-ORF7b topological analysis transcription factors [DOI] 10.3390/biom14050541 PMC 바로가기 [Article Type] Article
Carotenoids in Health as Studied by Omics-Related Endpointsarticle Published on 2023-09-092024-09-05 Journal: Advances in Nutrition [Category] update2024, [키워드] body tissues cellular compartments exposome Health Inflammation LC-MS-MS lutein Lycopene metabolites oxidative stress transcription factors β-carotene [DOI] 10.1016/j.advnut.2023.09.002 PMC 바로가기 [Article Type] article
Cytokine-Mediated Degradation of the Transcription Factor ERG Impacts the Pulmonary Vascular Response to Systemic Inflammatory ChallengeBasic Sciences Published on 2023-06-152024-09-05 Journal: Arteriosclerosis, Thrombosis, and Vascular Biology [Category] update2024, [키워드] capillary permeability endothelial cells Inflammation lung proteolysis transcription factors [DOI] 10.1161/ATVBAHA.123.318926 PMC 바로가기 [Article Type] Basic Sciences
Identification of key transcription factors and their functional role involved in Salmonella typhimurium infection in chicken using integrated transcriptome analysis and bioinformatics approach살모넬라 타이피무리움 감염에서 주요 전사 인자의 식별 및 그 기능적 역할: 통합 전사체 분석 및 생물정보학적 접근법을 이용한 닭에서의 연구Article Published on 2023-04-252024-08-22 Journal: BMC Genomics [Category] 살모넬라증, [키워드] bioinformatics chicken RNA seq Salmonella Typhimurium transcription factors
Intertwined Dysregulation of Ribosomal Proteins and Immune Response Delineates SARS-CoV-2 Vaccination Breakthroughsarticle Published on 2023-04-062024-09-05 Journal: Microbiology Spectrum [Category] update2024, [키워드] COVID-19 immune tolerance milder disease severity ribosomal proteins transcription factors vaccination breakthroughs [DOI] 10.1128/spectrum.04292-22 PMC 바로가기 [Article Type] article
A Bioinformatic Approach Based on Systems Biology to Determine the Effects of SARS-CoV-2 Infection in Patients with Hypertrophic CardiomyopathyArticle Published on 2022-09-272022-11-15 Journal: Computational and Mathematical Methods in Medicine [Category] SARS, 바이오마커, [키워드] acute respiratory syndrome Affect Analysis Bioinformatic Biology Biomarker Cardiomyopathy cardiovascular system Combination conducted coronavirus coronavirus disease COVID-19 COVID-19 progression datasets DEGs differentially expressed gene disorder drug drug candidates Effect functional Gene Expression Omnibus Genes Genetic GSE147507 identify individual knowledge Lungs microRNA mortality rate; ontology terms other organs patients with COVID-19 protein-protein interaction Proteins Research RNA SARS-CoV-2 Sequencing shared pathway shown statistical Support System therapy transcription factors transcriptomic while [DOI] 10.1155/2022/5337380 PMC 바로가기
Single-cell RNA sequencing uncovers the nuclear decoy lincRNA PIRAT as a regulator of systemic monocyte immunity during COVID-19Article Published on 2022-09-062022-11-15 Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 진단, [키워드] alarmin antiviral response approach binding blood leukocyte characterized COVID-19 COVID-19 pathogenesis differentially expressed down-regulation driver expression humans Immunity immunopathology JAK-STAT pathway knockout lincRNA lncRNA long noncoding RNA LUCAT1 monocyte Monocytes naïve NF-κB NF-κB-dependent gene noncoding RNA nuclear promote promoter pseudogene PU.1 Release remained RNA RNA sequencing SARS-CoV-2 SARS-COV-2 infection severe COVID-19 Single-cell RNA sequencing single-cell RNA-seq Stat1 suggested systemic immune response target Transcription transcription factor transcription factors transcriptional transgene viral infection [DOI] 10.1073/pnas.2120680119 PMC 바로가기
Transcriptome Analysis of Peripheral Blood Mononuclear Cells Response in Patients with Severe COVID-19 Reveals Crucial Genes Regulating Protein UbiquitinationArticle Published on 2022-08-292022-11-16 Journal: Medical science monitor : international medical jo [Category] 유전자 메커니즘, [키워드] Analysis ASB16 biological process Cell Characteristics Cluster conducted core gene COVID-19 COVID-19 pandemic DEGs detect differentially expressed gene enrichment evaluate expressed facilitate FBXO11 FOXA1 FOXC1 functional GATA2 Gene expression analysis Genes healthy controls hsa-miR-1-3p identify Interaction ITCH macrophages miRNA molecular mononuclear cell Patient performed peripheral Peripheral blood platform progression protein ubiquitination protein-protein interaction regulate Regulating Regulatory response RNA sequencing RNF130 severe COVID-19 signaling pathways single-cell transcription factors Transcriptome TRIM21 UBE2J1 was used were expressed YY1 [DOI] 10.12659/MSM.937532 PMC 바로가기
Pyroptotic Patterns in Blood Leukocytes Predict Disease Severity and Outcome in COVID-19 Patients혈액 백혈구의 Pyroptotic 패턴은 COVID-19 환자의 질병 심각도와 결과를 예측합니다Article Published on 2022-07-192022-09-11 Journal: Frontiers in Immunology [Category] 유전자 메커니즘, [키워드] acute respiratory distress acute respiratory distress syndrome ARDS blood leukocyte caused Clinical treatment Cluster Clustering Compound coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients deaths detrimental effects differentially expressed gene Differentially expressed genes disease effective enrichment analysis expression gene set enrichment analysis Genes GSEA hyperinflammation hyperinflammatory state IMPROVE LASSO leukocyte leukocytes operator pandemic Patient patients pattern Prognosis prognosis model prognostic model proteomic pyroptosis respiratory distress Respiratory distress syndrome syndrome therapeutic transcription factor transcription factors transcriptomic data Unsupervised clustering upstream worse prognosis [DOI] 10.3389/fimmu.2022.888661 PMC 바로가기 [Article Type] Article
Comparative genomic analysis of the human genome and six bat genomes using unsupervised machine learning: Mb-level CpG and TFBS islands비지도 머신 러닝을 사용한 인간 게놈과 6개의 박쥐 게놈 비교 게놈 분석: Mb 수준 CpG 및 TFBS 섬Comparative Study Published on 2022-07-082022-09-11 Journal: BMC Genomics [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] 3D structure 3D Structures addition Algorithm Analysis artificial artificial intelligence bat bats binding Centromeric heterochromatin characteristic Characteristics chromosomes class Clustering Comparative conducted contributing to CpG diagnostic dinucleotide disease-causing distribution Ebola Emerging infectious disease feature Features function Gene Expression Genome genomes genomic Genomic analysis help hosts Human Human genome humans Infectious disease information Interaction involved knowledge machine machine learning motif natural reservoir nuclear oligonucleotide Oligonucleotide composition oligonucleotides Protein Region regions Regulation reveal RNA viruses SARS-CoV-2 self-organization Self-organizing map Self-organizing map. sequence TFS the SARS-CoV-2 thought transcription factor transcription factors variety virus viruses zoonotic [DOI] 10.1186/s12864-022-08664-9 PMC 바로가기 [Article Type] Comparative Study