The CCCTC-binding factor CTCF represses hepatitis B virus enhancer I and regulates viral transcriptionArticle Published on 2021-02-042023-06-03 Journal: Cellular microbiology [Category] B형 간염, [키워드] CTCF epigenetics HBV transcription insulation transcription regulation [DOI] 10.1111/cmi.13274 PMC 바로가기 [Article Type] Article
Stress proteins: the biological functions in virus infection, present and challenges for target-based antiviral drug developmentReview Article Published on 2020-07-132022-10-04 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 신약개발, 치료제, [키워드] Alzheimer disease antiviral drug antiviral target biologic biological function Cancer cancer cell cardiovascular diseases caused Cell cellular homeostasis cellular processes chaperone chaperones chromatin clinical evaluation Compound COVID-19 disease Diseases Drug regulation Factor function heterogeneous HSP Hsps human disease immune Immunity include infections Inflammatory cytokines mechanism metabolism molecular Molecular biology neurodegenerative nuclear polypeptides presenting promote Protein ribonucleoprotein RNA RNA Polymerase II Stress Stress Protein stress proteins stroke survival transcribed transcription regulation virus virus virus infection virus replication [DOI] 10.1038/s41392-020-00233-4 PMC 바로가기 [Article Type] Review Article
Non-equilibrium repressor binding kinetics link DNA damage dose to transcriptional timing within the SOS gene network비평형 억제인자 결합 동역학은 SOS 유전자 네트워크 내에서 DNA 손상 용량을 전사 타이밍에 연결합니다Research Article Published on 2018-06-012022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Activation activity bacterial DNA best binding binding interaction binding kinetics Biochemical pathways cause Cell cellular Concentration Critical defined Degradation disequilibrium DNA binding DNA damage DNA damage repair pathway DNA damaging dose drop Escherichia coli expression Gene Expression Genes kinetic leads LexA low dose mechanism modulate network operator operators pathway Physiology promoter promoters rapid equilibrium assumptions regulate regulated Regulatory respond resulting reveal separated SOS gene SOS pathway SOS response subset the cell the timing These data Transcription transcription factor transcription regulation transcriptional transcriptional repressor Trigger triggers [DOI] 10.1371/journal.pgen.1007405 PMC 바로가기 [Article Type] Research Article
Microevolution of Candida albicans in Macrophages Restores Filamentation in a Nonfilamentous Mutant대식세포에서 칸디다 알비칸스의 소진화는 필라멘트가 아닌 돌연변이에서 필라멘트를 복원합니다Research Article Published on 2014-12-042022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] addition Antifungal treatment approach avirulent C. albican C. albicans Candida Candida albican Candida albicans Cdk8 Cell cell wall clinical setting complex component Compound connection drug resistance ENCODE environmental cue environmental cues Evolution example exhibited fungi gene encoding growth hosts hyphae hyphal identify in vivo Incubation induce Infection leads Macrophage macrophages maintain mechanism mediator Mediator complex microbe microevolution microevolutionary microorganism microorganisms Missense mutation murine mutant Mutation nucleotide pathogenic pathogenicity phagocytosis regulatory network responsible selection pressure Signaling signaling pathway single nucleotide strain subject the macrophage phagosome These data took place Transcription transcription factor transcription factors transcription regulation transcriptional transcriptional regulation undergo virulence whole genome yeast [DOI] 10.1371/journal.pgen.1004824 PMC 바로가기 [Article Type] Research Article