Aspergillus fumigatus secretes a protease(s) that displays in silico binding affinity towards the SARS-CoV-2 spike protein and mediates SARS-CoV-2 pseudovirion entry into HEK-293T cellsResearch Published on 2024-03-062024-09-05 Journal: Virology Journal [Category] update2024, [키워드] A. Fumigatus alkaline protease 1 Aspergillus (A) fumigatus HADDOCK HEK-293T cells SARS-CoV-2 spike protein supernatant transduction [DOI] 10.1186/s12985-024-02331-z PMC 바로가기 [Article Type] Research
Evaluation of Malarial Var2CSA-Displaying Baculovirus Vector in Transduction Efficiency in Human Cancer Cellsarticle Published on 2023-12-312024-09-01 Journal: Biological and Pharmaceutical Bulletin [Category] 말라리아, [키워드] baculovirus vector cancer gene therapy transduction variant surface antigen 2-chondroitin sulfate A (var2CSA) [Article Type] article
Transcriptomic analysis of the innate immune signatures of a SARS-CoV-2 protein subunit vaccine ZF2001 and an mRNA vaccine RRVSARS-CoV-2 단백질 소단위 백신 ZF2001 및 mRNA 백신 RRV의 타고난 면역 특징의 전사체 분석Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, [키워드] Activation Analysis Anti-viral antibody approach binding CD74 Cell comparable COVID-19 cytokine Cytokines early response elicited expression level expression of gene framework Gene Expression Genes immune response immune responses immunization innate immune innate immune response Innate immunity involved mapped MHC class mRNA mRNA vaccine neutralization Neutralization antibody Pattern recognition pattern recognition receptor Pattern recognition receptors post vaccination Protein subunit protein subunit vaccine PRRs RNA degradation robust SARS-CoV-2 SARS-CoV-2 protein subunit Subunit vaccine Tap1 titre titres Transcription transcriptional Transcriptome transcriptome sequencing transcriptomic transduction Vaccine ZF2001 [DOI] 10.1080/22221751.2022.2059404 PMC 바로가기 [Article Type] Article
Recombinant Protein Micelles to Block Transduction by SARS-CoV-2 PseudovirusArticle Published on 2022-10-252022-11-16 Journal: ACS Nano [Category] COVID19(2023년), SARS, 변종, [키워드] antibody Baker block Cell cloned Combination Concentration DAVID Delta delta variant E. coli expressing functional protein Genetic human cells Infection Laboratory micelle Mini-Proteins molecular multifunctional multivalent Multivalent Micelles N-terminus non-toxic Oleosin peptides performed Precision Protein Proteins receptor recombinant Recombinant protein reduced reducing S1 protein SARS-CoV-2 SARS-CoV-2 pseudovirus scattering Seattle self-assembly the SARS-CoV-2 virus the Spike Therapies transduction variant wild-type [DOI] 10.1021/acsnano.2c09015 PMC 바로가기
Early Isolates of SARS-CoV-2 Result in Different Pathogenesis in the Transduced Mouse Model of COVID-19SARS-CoV-2의 초기 분리물은 COVID-19의 형질도입된 마우스 모델에서 다른 병인을 초래합니다Article Published on 2022-08-132022-09-11 Journal: Viruses [Category] SARS, 변종, [키워드] Adenovirus alveolar inflammation BALB/c mice body weight Body weight loss Clinical sign Clinical signs COVID-19 dissemination expression followed by hACE2 hACE2 receptor Histopathology in vivo Infection isolate isolates kidney liver lung Lung histopathology Lungs mice Model mouse mouse model peaking post infection provide response Result resulting SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus SARS-CoV-2 virus variant spleen subsequent recovery susceptible the SARS-CoV-2 virus transduced transduction undetectable Victoria viral variant Viral variants virulence virus weight loss [DOI] 10.3390/v14081769 PMC 바로가기 [Article Type] Article
The battle between host and SARS-CoV-2: Innate immunity and viral evasion strategies숙주와 SARS-CoV-2의 전투: 선천 면역과 바이러스 회피 전략Review Published on 2022-05-042022-09-11 Journal: Molecular therapy : the journal of the American So [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료기술, 치료제, [키워드] activated Antiviral antiviral gene antiviral genes antiviral targets caused confirmed cases COVID-19 death Defense evade highlight Host host response immune immune evasion immune surveillance Immunity Inflammation Innate innate immune innate immune response innate immune system Innate immunity interferon interferons Invasion knowledge life cycle mechanism pathogen Pattern recognition pattern recognition receptor Pattern recognition receptors PRRs recognizing Replication restrict resulting SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus Signaling signaling cascade signaling transduction. Surveillance transduction type I type I and III interferons viral life cycle viral spread [DOI] 10.1016/j.ymthe.2022.02.014 PMC 바로가기 [Article Type] Review
A Simplified SARS-CoV-2 Mouse Model Demonstrates Protection by an Oral Replicon-Based mRNA Vaccine단순화된 SARS-CoV-2 마우스 모델은 경구 레플리콘 기반 mRNA 백신에 의한 보호를 보여줍니다Immunology Published on 2022-02-162022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, 치료제, [키워드] addition Adenovirus angiotensin anti-SARS-CoV-2 carried characteristic cross-protective determine domain drug epitope Epitopes expressing expression forest gene delivery glycoprotein hACE2 heptad repeat human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 immunized mice immunohistochemistry in vitro in vivo Infectious disease Infectious diseases interstitial pneumonia lab lung Lung disease Lung pathology Lungs Macrophage macrophages membrane membrane glycoprotein mice Model moderate Molecular biology mouse mouse model mRNA mRNA expression mRNA vaccine murine Neutralizing antibodies neutralizing antibody nine nsp13 oral parental peptide peptides protection purification qPCR RBD Receptor binding domain recorded RT-PCR Salmonella SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 mouse model Support supported target the SARS-CoV-2 therapy transduced transducing transduction utility Vaccine Vaccine design Vaccines variant Viral viral replication virus was determined weight loss were assessed [DOI] 10.3389/fimmu.2022.811802 PMC 바로가기 [Article Type] Immunology
Functional Severe Acute Respiratory Syndrome Coronavirus 2 Virus-Like Particles From Insect CellsMicrobiology Published on 2021-10-202022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] acute respiratory syndrome Coronaviral coronavirus coronavirus 2 coronavirus disease COVID-19 disease Epidemic facilitate Heterologous Infection insect insect cell insect cells Particle Particles produced Protein pseudovirus purification purified replicate Research respiratory Safe SARS CoV-2 SARS-CoV-2 SARS-CoV-2 VLP transduction viral genome virus Virus-like particle virus-like particles VLP VLPs [DOI] 10.3389/fmicb.2021.732998 PMC 바로가기 [Article Type] Microbiology
Doxycycline Inhibition of a Pseudotyped Virus Transduction Does Not Translate to Inhibition of SARS-CoV-2 Infectivity의사 타입 바이러스 형질 도입의 독시사이클린 억제는 SARS-COV-2 감염성의 억제로 해석되지 않는다.Article Published on 2021-09-012022-09-10 Journal: Viruses [Category] SARS, 유전자 메커니즘, [키워드] angiotensin angiotensin-converting enzyme 2 anti-viral activity approach binding biological processe biological processes caused Clinical data clinical trial clinical trials clinically Compound compounds COVID-19 criteria doxycycline expressing HEK-293 in vitro Infection Infectivity information inhibited inhibition interfere mechanism not affect pandemic platform Pleiotropic effects Pseudotyped virus receptor Replication replication of SARS-CoV-2 resources SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 strain SARS-CoV-2 virus Spike protein Spread surface plasmon resonance T cell T cells tetracyclines the SARS-CoV-2 virus the spike protein therapeutic transduction Vero E6 virus [DOI] 10.3390/v13091745 PMC 바로가기 [Article Type] Article
Intranasal Administration of a Monoclonal Neutralizing Antibody Protects Mice against SARS-CoV-2 Infection단일 클론 중화 항체의 비강 내 투여는 SARS-COV-2 감염으로부터 마우스를 보호한다.Article Published on 2021-07-292022-09-01 Journal: Viruses [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Administered animal experiments anti-SARS-CoV-2 anti-SARS-CoV-2 antibodies antiviral potency B.1.1.7 B.1.351 bind Bioavailability clinical trial clinical trials coronavirus drugs Effectiveness highlight human SARS-CoV-2 in vitro in vivo injected intravenously intranasal intranasal administration lead lung Lung pathology Lungs mice monoclonal monoclonal antibody neutralize Neutralizing Neutralizing antibodies neutralizing antibody pandemic Particle pharmacokinetic Prophylactic prophylactically Receptor-binding domain reduced respiratory respiratory virus respiratory viruses SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 spike protein Spike protein the receptor-binding domain the SARS-CoV-2 therapeutic topical administration transduction Vaccine variant virus viruses VoC [DOI] 10.3390/v13081498 PMC 바로가기 [Article Type] Article