Serum angiotensin-converting enzyme 2 as a potential biomarker for SARS-CoV-2 infection and vaccine efficacyArticle Published on 2022-10-122022-11-15 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 바이오마커, [키워드] ACE2 angiotensin-converting enzyme 2 Biomarker change changes in circulating cleaved COVID-19 death declined demonstrated Disease progression dose Efficacy elevated expressing full-length highlight host cell receptor human ACE2 humans immunization increase in K18-hACE2 mice membrane mice MVA-S vaccine prevented Proteolytic processing receptor SARS-CoV-2 SARS-COV-2 infection serum serum sample subsequent susceptible the SARS-CoV-2 transgenic vaccination Vaccine vaccine candidate virus virus entry [DOI] 10.3389/fimmu.2022.1001951 PMC 바로가기
Resolving SARS-CoV-2 CD4 + T cell specificity via reverse epitope discovery역 에피토프 발견을 통한 SARS-CoV-2 CD4 + T 세포 특이성 해결Meta-Analysis Published on 2022-08-162022-09-11 Journal: Cell Reports Medicine [Category] COVID19(2023년), SARS, 치료기술, [키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antigen approach CD4 CD4 T cells Cluster coronavirus COVID-19 dataset detect epitope epitope discovery FIVE functional cell HLA identify immunodominant individual infected individuals information Intensive labor leukocyte Meta-analysis pathogen peptide peptide pool public T cell response. recognizing responses SARS-CoV-2 sequence similarity severe acute respiratory syndrome Coronavirus similarity single-cell specificity T cell T cell receptor T cell receptors T cell response T cells TCR TCR repertoire TCRs These data transgenic utility [DOI] 10.1016/j.xcrm.2022.100697 PMC 바로가기 [Article Type] Meta-Analysis
Passive immunization with equine RBD-specific Fab protects K18-hACE2-mice against Alpha or Beta variants of SARS-CoV-2Article Published on 2022-08-152022-11-16 Journal: Frontiers in Immunology [Category] SARS, 변종, [키워드] ACE2 receptor binding addition administration antibody Beta clearance contributed country COVID-19 COVID-19 pandemic creating delta variant disease dose doses Efficacy emergence EpF(ab’)2 equine Equine F(ab’)2 Fab HBsAg immunization implementation increased survival Infection intranasal K18-hACE2 K18-hACE2 transgenic mice mice monoclonal antibody treatment neutralize omicron outcome pandemic passive immunization peripheral circulation phenotype polyclonal polyclonal antibodies PROTECT RBD SARS-CoV-2 SARS-COV-2 infection Severe case severe disease severe SARS-CoV-2 strain survival tested therapeutic Therapeutic treatment tissues transgenic Treatment variant variant of concern (VOC) variants variants of concern variants of SARS-CoV-2 Viral RNA virus VoC [DOI] 10.3389/fimmu.2022.948431 PMC 바로가기
BSL2-compliant lethal mouse model of SARS-CoV-2 and variants of concern to evaluate therapeutics targeting the Spike proteinSARS-CoV-2의 BSL2 호환 치명적인 마우스 모델 및 Spike 단백질을 표적으로 하는 치료제 평가를 위한 우려 변종Article Published on 2022-07-282022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 transgenic mice acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 animal model antibody both virus both viruses brains BSL-2 BSL-2 mouse model BSL2 BSL3 BST2 can be used CCL5 change competent concern conditions coronavirus COVID-19 COVID19 CXCL10 disease Disease progression drugs Encephalitis evaluate experimental therapeutics facilitate faster generate GFP glycoprotein hACE2 host-pathogen interactions in vivo increased expression Infection interferon IRF7 K18-hACE2 K18-hACE2 transgenic mice lethal infection LILRB4 lung Lungs mass vaccination mice modulate mouse model mutations Neonatal neuronal infection neurotropism pathogenicity prophylactic treatment Protein pseudotyped Pseudotyped virus Receptor binding domain replaced REPLACED BY Replication reported SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variants SARS-CoV-2 viruses SARS2 severe acute respiratory syndrome Coronavirus Spike protein stomatitis successive wave successive waves the SARS-CoV-2 the Spike the spike protein therapeutic Therapeutics transgenic transgenic mice Transmission vaccination Vaccine development variant variants of concern vesicular vesicular stomatitis vesicular stomatitis virus virulence virus VoC VSV VSV (vesicular stomatitis virus) [DOI] 10.3389/fimmu.2022.919815 PMC 바로가기 [Article Type] Article
Animal models for COVID-19: advances, gaps and perspectivesCOVID-19에 대한 동물 모델: 발전, 격차 및 전망Review Published on 2022-07-072022-09-11 Journal: Signal Transduction and Targeted Therapy [Category] COVID19(2023년), SARS, 바이오마커, 변종, 유전자 메커니즘, 진단, 치료제, [키워드] ADE animal animal model animal models Antibody-dependent enhancement caused cells Characteristics clinical feature Clinical features combinations Comorbidity COVID-19 evaluate ferret host receptor Host receptors hosts human tissue human tissues immune response immune responses Infection livestock mice mouse model Mouse models mouse-adapted strain non-human primates outbreak pandemic Pathogenesis pathogenesis of SARS-CoV-2 Perspective populations poultry protease Proteases receptor receptors SARS-CoV-2 SARS-COV-2 infection strain susceptible therapy transduced transgenic variants variants of concern virulence VoC [DOI] 10.1038/s41392-022-01087-8 PMC 바로가기 [Article Type] Review
Emerging trends of edible vaccine therapy for combating human diseases especially COVID-19: Pros, cons, and future challenges인간 질병, 특히 COVID-19 퇴치를 위한 식용 백신 요법의 새로운 경향: 찬반 양론 및 미래 과제Review Published on 2022-07-012022-09-11 Journal: Phytotherapy research : PTR [Category] 유전자 메커니즘, [키워드] administration clinical trials combating conventional vaccine conventional vaccines COVID-19 develop drugs edible vaccine effective effort Evidence human disease human diseases immunomodulatory mechanism mechanism of action minimum monoclonal antibodies oral administration oral vaccines Perspective plant plant-extracts plants PROTECT Proteins researcher SARS-CoV-2 Side effect Side effects stages therapy transgenic transgenic plant. Vaccine vaccine candidate Vaccines [DOI] 10.1002/ptr.7475 PMC 바로가기 [Article Type] Review
K18- and CAG-hACE2 Transgenic Mouse Models and SARS-CoV-2: Implications for Neurodegeneration ResearchK18- 및 CAG-hACE2 형질전환 마우스 모델 및 SARS-CoV-2: 신경변성 연구에 대한 시사점Review Published on 2022-06-282022-09-11 Journal: Molecules [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] absence ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antiviral drug Autopsy Brain brain regions brain tissue CAG-hACE2 transgenic mice caused cells Central nervous system Confusion Consequences coronavirus COVID-19 COVID-19 patient COVID-19 patients Cytokines demonstrated develop direct infection disorder disorders dissect Encephalitis entry receptor enzyme evaluate glial cell global pandemic hACE2 helping human Angiotensin-converting enzyme Human brain increase in infected with SARS-CoV-2 Inflammation K18 K18-transgenic mice leukocyte leukocyte infiltration life manifestation mechanism Meningitis Mental Model molecular mouse Mouse models mucosa neuroinvasion neurological Neurological complication Neurological complications neuronal neurons olfactory Patient periphery pro-inflammatory cytokine pro-inflammatory cytokines provoke Quality of life reported responses robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 neuroinvasion severe acute respiratory syndrome Coronavirus suggested survivor therapy transgenic Transgenic mouse Vaccine development [DOI] 10.3390/molecules27134142 PMC 바로가기 [Article Type] Review
Live imaging of platelets and neutrophils during antibody-mediated neurovascular thrombosis항체 매개 신경 혈관 혈전증 동안 혈소판 및 호중구의 실시간 영상Article Published on 2022-06-282022-09-12 Journal: Blood advances [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] absence activate acute respiratory syndrome adenoviral vector vaccine administration allergic disease analyses animal model approach Autoimmune Blood Brain can be used cellular cellular response complexes coronavirus disease downstream Endothelium event expressing immune complex Immune complexes implicated Infection interactions leukocyte medications mice Neurovascular neutrophil pathogenic Platelet Platelets quantification receptor rheumatological SARS-CoV-2 systemic disorder thrombosis thrombotic thrombotic complication transgene transgenic vasculature vessel walls [DOI] 10.1182/bloodadvances.2021006728 PMC 바로가기 [Article Type] Article
Furin and TMPRSS2 Resistant Spike Induces Robust Humoral and Cellular Immunity Against SARS-CoV-2 Lethal Infection푸린 및 TMPRSS2 내성 스파이크는 SARS-CoV-2 치명적인 감염에 대한 강력한 체액 및 세포 면역을 유도합니다Article Published on 2022-05-022022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 transgenic mice Against Amino acid antibody response against blocked C-terminal CD8 cleavage site clone clones COVID-19 vaccine effective Express furin furin cleavage furin cleavage site hamsters identify in some induce intranasal lethal Mutation mutations produced protective immunity Protein pseudotype Replication replication-competent. Resistant robust S antigen S protein S1/S2 cleavage S1/S2 cleavage site SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 spike protein SARS-CoV-2 variant single dose spike Spike protein T cell T cell response the SARS-CoV-2 TMPRSS2 transgenic unmet need vaccination Vaccine Vaccine design variant vesicular stomatitis vesicular stomatitis virus virus VSV was used [DOI] 10.3389/fimmu.2022.872047 PMC 바로가기 [Article Type] Article
A pair of noncompeting neutralizing human monoclonal antibodies protecting from disease in a SARS-CoV-2 infection modelSARS-CoV-2 감염 모델에서 질병으로부터 보호하는 한 쌍의 비경쟁 중화 인간 단일클론 항체Article Published on 2022-05-012022-09-11 Journal: European Journal of Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Analysis animals antibodies antibody binding candidate cellular receptor cellular receptor hACE2 Cluster competing COVID-19 disease DNA DNA sequence hACE2 human ACE2 human immunoglobulin human monoclonal antibodies Human monoclonal antibody IC50 Immunoglobulin mice N-terminal domain neutralize neutralized Neutralizing Neutralizing antibodies neutralizing antibody pandemic platform powerful tool Prophylaxis Receptor-binding domain reduced SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 mutant SARS-CoV-2 mutants SARS-CoV-2 neutralizing antibody SARS-CoV-2 spike protein selected Spike protein Support the receptor-binding domain the SARS-CoV-2 the spike protein therapy transgenic variants variants of concern Viral viral spread weight loss [DOI] 10.1002/eji.202149374 PMC 바로가기 [Article Type] Article