Cost-Effectiveness Analysis of Molnupiravir Versus Best Supportive Care for the Treatment of Outpatient COVID-19 in Adults in the US미국 성인의 코로나19 외래환자 치료를 위한 몰누피라비르 대 최상의 지지 요법의 비용 효율성 분석Article Published on 2022-07-012022-09-11 Journal: PharmacoEconomics [Category] MERS, 바이오마커, 변종, [키워드] acute phase adult outpatient adult outpatients Adult patients affected Analysis Antiviral best Care changes changes in conducted coronavirus disease Coronavirus disease 2019 Cost effectiveness COVID-19 COVID-19 outpatients database de novo Decision tree decrease died dominant effective Electronic health record Electronic health records evaluated healthcare Healthcare system highest Hospitalization Hospitalized Immunity increase in information Intervention less Markov medical costs Mild-to-moderate molnupiravir outcome Outpatient pandemic parameter Patient patient population Perspective Primary outcomes Probability progression proportion real-world data reduction remained reported Research risk sensitivity analysis severe disease Society supportive care Therapies threshold transition transition probabilities treated treating COVID-19 Treatment Trial unavailability utility vaccination Viral Viral variants with COVID-19 [DOI] 10.1007/s40273-022-01168-0 PMC 바로가기 [Article Type] Article
Modelling conformational state dynamics and its role on infection for SARS-CoV-2 Spike protein variants모델링 형태 상태 역학 및 SARS-COV-2 스파이크 단백질 변이체에 대한 감염에 대한 역할Research Article Published on 2021-08-052022-08-13 Journal: PLoS Computational Biology [Category] MERS, SARS, 변종, 유전자 메커니즘, [키워드] 501.V2 ACE2 alternative methods B.1.1.7 calculate cell entry computational method conformational COVID-19 D614G decrease facilitate flexibility glycine helping human ACE2 receptor identify increase in Infection K417 knowledge less matter mechanism molecular mechanism molecular mechanisms multiple mutation multiple mutations Mutation N501Y N501Y mutation new strain normal mode analysis open Pandemics predict proof proof of concept Protein public health residue residues resource SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein several variant several variants Simulation specific mutation specific mutations spike Spike protein Strains Surveillance the SARS-CoV-2 the Spike transition probabilities transition probability treat variant variants Viral viral entry virus [DOI] 10.1371/journal.pcbi.1009286 PMC 바로가기 [Article Type] Research Article
Joint analysis of duration of ventilation, length of intensive care, and mortality of COVID-19 patients: a multistate approachResearch Article Published on 2020-08-112022-10-28 Journal: BMC Medical Research Methodology [Category] Coronavirus, Fulltext, MERS, [키워드] addition Analysis analyzed approach average baseline characteristics clinically Cohort comparison competing Competing risks COVID-19 COVID-19 patient data set death discharge ECMO entire cohort estimate event example expected extracorporeal membrane oxygenation Follow-up healthcare higher risk ICU information intensive care invasive ventilation Length of stay mechanical ventilation mechanically ventilated methodology Mortality Multistate model outcomes Patient patients hospitalized Perspective predicted Probability proportion Result SARS-CoV-2 severe pneumonia statistical statistical framework supportive therapy survival the patient transition probabilities two group ventilated patient Ventilation [DOI] 10.1186/s12874-020-01082-z PMC 바로가기 [Article Type] Research Article