The Drosophila melanogaster ACE2 ortholog genes are differently expressed in obesity/diabetes and aging models: Implications for COVID-19 pathologyArticle Published on 2022-12-012022-11-15 Journal: Biochimica et biophysica acta. Molecular basis of [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] ACE2 ACE2 ortholog ACE2 orthologs ACE2 receptor Acer age analyzed Ance animal model approach bind binding affinity complement coronavirus disease COVID-19 COVID-19 pathology COVID-19 severity death dependent on diabetes disorders Drosophila melanogaster Effect elderly ENhance expressed Factors glycoprotein host cells humans increase individual interact Interaction molecular molecular docking mRNA expression obesity ortholog predicted Protein regions regulated Research responsible risk factor Risk factors robust SARS-CoV-2 SARS-CoV-2 variant shown spike spike-ACE2 susceptible the Spike translational Transmissibility virus [DOI] 10.1016/j.bbadis.2022.166551 PMC 바로가기
Care of the Seriously Ill Patient with SARS-CoV-2Article Published on 2022-11-012022-11-16 Journal: The Medical clinics of North America [Category] SARS, 변종, [키워드] caused contributing to COVID-19 COVID-19 pandemic Critical care effective vaccine examined Health Ill knowledge medication pandemic Patient SARS-CoV-2 translational Treatment variant [DOI] 10.1016/j.mcna.2022.08.002 PMC 바로가기
News from around the RNA world: new avenues in RNA biology, biotechnology and therapeutics from the 2022 SIBBM meetingArticle Published on 2022-10-152022-11-16 Journal: Biology open [Category] 유전자 메커니즘, [키워드] Biology Biophysics cell differentiation cellular Circular circular RNAs Community COVID19 disease DNA Dogma highlighting information International involved Italian modulating Molecular biology National New Non-coding RNAs, microRNAs Pandemics Protein provided RNA RNA therapies. RNAs Rome Society Stress Therapies therapy transcript translational [DOI] 10.1242/bio.059597 PMC 바로가기
Upcoming and urgent challenges in critical care research based on COVID-19 pandemic experienceReview article Published on 2022-10-012022-10-05 Journal: Anaesthesia, critical care & pain medicine [Category] 바이오마커, [키워드] Admission applied characterisation clinical care Consequences coronavirus disease country COVID-19 COVID-19 pandemic Critical care develop Efficiency effort group healthcare Healthcare system highlight IMPROVE intensive care International pandemic Pandemics Perspectives physician Predictive Regulatory Research researcher Stress Symptoms the disease therapeutic translational Treatment Upcoming while [DOI] 10.1016/j.accpm.2022.101121 [Article Type] Review article
Accelerating model-informed decisions for COVID-19 vaccine candidates using a model-based meta-analysis approachArticle Published on 2022-10-012022-11-15 Journal: EBioMedicine [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Analysis applied approach calibrated candidate carried clinical Clinical efficacy clinical trial convalescent CoronaVac COVID-19 COVID-19 pandemic COVID-19 vaccine develop Efficacy humans immunogenicity data Inc. joint literature review LLC Meta-analysis Model-based meta-analysis (MBMA) modelling Modelling and simulation Neutralizing predict predicted Predictive Predictive model Quantitative reported rhesus macaque Safe SARS-CoV-2 SARS-CoV-2 vaccines serum Sharp strain Study design Support systematic literature search the mean titre translation translational USA vaccination Vaccine vaccine candidate Vaccines variant Viral load were used [DOI] 10.1016/j.ebiom.2022.104264 PMC 바로가기
Integrating basic science with translational research: the 13th International Podocyte Conference 2021Short communication Published on 2022-10-012022-10-05 Journal: Kidney international [Category] 비임상, [키워드] 13th International Podocyte Conference Abstract addition Basic science Clinicians Conference coronavirus disease COVID-19 Day Diagnosis global pandemic introduced meeting report offered pandemic pathway Patient patients podocyte podocyte2021 Research researcher researchers Resilience selected Therapies translational [DOI] 10.1016/j.kint.2022.07.021 [Article Type] Short communication
Nanosponges: An overlooked promising strategy to combat SARS-CoV-2Article Published on 2022-10-012022-11-15 Journal: Drug discovery today [Category] COVID19(2023년), SARS, 치료제, [키워드] acute respiratory syndrome Antiviral Antiviral delivery approach Biological Biological neutralization biosafety complex coronavirus Coronavirus 2019 COVID-19 exhibited in vitro model inactivation inhibitory effect mechanism Nanosponges neutralization SARS-CoV-2 SARS-COV-2 infection therapeutic target translational viral inactivation [DOI] 10.1016/j.drudis.2022.07.015 PMC 바로가기
Singularity and Commonality in Response to SARS-CoV-2 in Lung and Colon Cell ModelsArticle Published on 2022-09-092022-11-15 Journal: International Journal of Molecular Sciences [Category] SARS, 치료제, [키워드] addressed Analysis Antiviral APOBEC APOBEC3G APOBECs approach both virus Caco-2 Caco-2 cell Caco-2 cells Calu-3 Calu-3 cell Calu-3 cell line Cell cell line cellular cellular response Colon commonality Course COVID-19 dataset determine differentially expressed gene disease Diseases epithelial cell events Evidence expressed genes expression pattern Factors feature gastrointestinal tract gene expression level gene signatures host response intrinsic liver lung lung; manifestation Model molecular outcome Pathomechanism Pathways performed Perturbation provide question Research Respiratory system response SARS-CoV SARS-CoV-2 similarity Systems biology the interferon tissue expression transcriptomic translational unique [DOI] 10.3390/ijms231810451 PMC 바로가기
Perspectives in Melanoma: meeting report from the Melanoma Bridge (December 2nd – 4th, 2021, Italy)Article Published on 2022-09-042022-11-15 Journal: Journal of Translational Medicine [Category] 바이오마커, 유전자 메커니즘, [키워드] Accuracy addition adjuvant advance adverse events Algorithm anti-CTLA-4 Anti-PD-1 approach approved Biomarker Biomarkers biopsy BRAF BRAF inhibitor bridge cancers Cell characterized Chemotherapy clinically Combination Combination strategies combination therapy combination treatment COVID-19 pandemic development Diagnosis Drug administration Efficacy effort Evidence feature genomic help Host immune response immune Immune checkpoint inhibitor immune response Immunotherapy improve diagnostics Improved Italy lesions management mechanism mechanism of action MEK inhibitor Melanoma Naples Neoadjuvant oncogenic overcome Patient patients platform Precision predict Predictive Radiotherapy Research robust specific treatment survival systemic and local target target therapy tested therapeutic therapeutic agent therapy translational treatment regimens tumor immunity tumor microenvironment Vaccine viruses [DOI] 10.1186/s12967-022-03592-4 PMC 바로가기
Identification of a novel immune-inflammatory signature of COVID-19 infections, and evaluation of pharmacokinetics and therapeutic potential of RXn-02, a novel small-molecule derivative of quinoloneResearch article Published on 2022-09-012022-10-05 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료기술, 치료제, [키워드] A549 activity acute respiratory syndrome addition Analysis AUC binding binding affinity Bioinformatics analysis candidate caused Cell cell line clinical investigation Colon conducted coronavirus Coronavirus disease 2019 COVID-19 COVID-19 (Coronavirus disease 2019) COVID-19 infections dataset drug drug target effector memory Efficacy evaluated exhibited FIVE gene signature global pandemic human lung IC50 identification immune immunomodulation immunomodulatory immunosuppressive in vitro in vivo Inflammation Inflammatory Lungs peak plasma concentration pharmacokinetics positive-sense RNA virus respiratory infection SARS-CoV-2 SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) SARS-CoV-2 drug SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 pathogenesis SARS-CoV-2-infected patient suggested T cell therapeutic options therapeutic potential therapy threat transcriptomic translation translational vaccine candidates value [DOI] 10.1016/j.compbiomed.2022.105814 [Article Type] Research article