Geography and health: role of human translocation and access to careEditorial Published on 2024-05-232024-09-05 Journal: Infectious Diseases of Poverty [Category] update2024, [키워드] Climate change emerging diseases Evolution of pathogens Geography human mobility Infectious diseases pathogen transmission re-emerging diseases Spatial analysis translocation [DOI] 10.1186/s40249-024-01205-4 PMC 바로가기 [Article Type] Editorial
Elucidation of the inhibitory activity of ivermectin with host nuclear importin α and several SARS-CoV-2 targetsArticle Published on 2022-11-012022-11-15 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 치료제, [키워드] 3CL pro 3CLpro acting antiviral activity approach binding binding free energy complex COVID-19 dimeric docked complexes docking explained FDA-approved drug FIVE heterodimeric Host in vitro activity inhibit inhibitor inhibitory activity Ivermectin MD simulation molecular molecular docking Molecular dynamics simulation molecular mechanism nuclear previous study protease Proteins reached Replication responsible SARS-CoV-2 SARS-CoV-2 replication shown Structural analysis structural property target translocation variety virus with COVID-19 [DOI] 10.1080/07391102.2021.1911857 PMC 바로가기
Cell-impermeable staurosporine analog targets extracellular kinases to inhibit HSV and SARS-CoV-2Article Published on 2022-10-162022-11-15 Journal: Communications Biology [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] activate antivirals Apoptosis blocked Ebola virus Extracellular glycoprotein herpes simplex virus inhibit inhibited kinase Kinase inhibitor outer membrane Phosphorylation plasma membrane promote Protein pseudotyped receptor engagement SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 spike protein signaling pathway subsequent target translocation triggered triggering unique vesicular stomatitis virus viral entry virus VSV [DOI] 10.1038/s42003-022-04067-4 PMC 바로가기
Unveiling the “Template-Dependent” Inhibition on the Viral Transcription of SARS-CoV-2SARS-CoV-2의 바이러스 전사에 대한 "템플릿-의존성" 억제 공개Article Published on 2022-08-112022-09-11 Journal: The journal of physical chemistry letters [Category] COVID19(2023년), SARS, 치료제, [키워드] acting active site Antiviral complementary COVID-19 pandemic demonstrated drug resistance inhibition inhibitors inhibitory investigated mechanism mechanisms molecular mechanism Mutation NTP nucleotide occur provided RdRP RdRps Remdesivir RNA synthesis RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 RdRp SARS-CoV-2 RNA steric translocation V557L [DOI] 10.1021/acs.jpclett.2c01314 PMC 바로가기 [Article Type] Article
A case of Bacillus subtilis var. natto bacteremia caused by ingestion of natto during COVID-19 treatment in a maintenance hemodialysis patient with multiple myelomaCase report Published on 2022-08-012022-10-05 Journal: Journal of infection and chemotherapy : official j [Category] 변종, 치료법, [키워드] acute respiratory syndrome Admission age association B. subtilis Bacillus subtilis Bacteremia Bacteria Bacterial Blood caused conditions coronavirus coronavirus disease COVID-19 Critical Culture cultures Diabetes Mellitus Diabetic diagnosed during treatment End-stage renal disease Hemodialysis hospital Immunocompromised immunosuppressive ingestion intestinal inflammation intestinal permeability malignant tumor Multiple myeloma nephropathy next-generation sequencer Patient risk steroid symptomatic the patient therapy Tocilizumab translocation treated Treatment vancomycin VAR [DOI] 10.1016/j.jiac.2022.05.006 [Article Type] Case report
Genetically Encoded Fluorescent Sensors for SARS-CoV-2 Papain-like Protease PLproSARS-CoV-2 Papain-like Protease PLpro용 유전적으로 인코딩된 형광 센서Article Published on 2022-07-152022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] acceptor Biliverdin Cell cleavage co-expression coronavirus COVID-19 detect Donor downstream Endoplasmic reticulum energy transfer enzymatic activity fluorescence intensity fluorescent fluorescent protein FRET genetically encoded probes HeLa cells increase in inhibitors lifecycle linker live cell live cell imaging live cells membrane mNeonGreen non-structural protein non-structural proteins nsp1 NSP2 Nsp3 Papain Papain-like protease PLPro polyprotein protease protease PLpro Protein SARS-CoV-2 SARS-CoV-2 propagation sensor separated Stage the SARS-CoV-2 translocation [DOI] 10.3390/ijms23147826 PMC 바로가기 [Article Type] Article
Gut-derived low-grade endotoxaemia, atherothrombosis and cardiovascular disease Reviews Published on 2022-07-152022-10-05 Journal: Nature reviews. Cardiology [Category] 바이오마커, [키워드] Affect arteries Artery atherosclerotic atherosclerotic plaques cardiovascular disease cell types changes in circulation clinical study demonstrated described dysfunction endothelial cells endotoxaemia Factor Gram-negative bacteria Gut IMPROVE Inflammation intestinal leukocytes lipopolysaccharide LPS mechanism membrane Patient plaque instability Platelet pro-inflammatory status promote review risk risk factor suggested systemic systemic inflammation therapeutic thrombus formation translocation [DOI] 10.1038/s41569-022-00737-2 [Article Type] Reviews
Sec61 Inhibitor Apratoxin S4 Potently Inhibits SARS-CoV-2 and Exhibits Broad-Spectrum Antiviral ActivitySec61 억제제 아프라톡신 S4는 SARS-CoV-2를 강력하게 억제하고 광범위한 항바이러스 활성을 나타냅니다Article Published on 2022-07-082022-09-11 Journal: ACS Infectious Diseases [Category] COVID19(2023년), SARS, 진단, 치료법, 치료제, [키워드] activity anticancer Antiviral antiviral activities antiviral activity blocked broad-spectrum antivirals cellular characterization COVID-19 Dengue dengue virus double-membrane vesicles dsRNA elicit Endoplasmic reticulum high potency Host host-directed therapeutics. human cells impacted in vitro in vivo Influenza influenza A influenza A virus inhibited inhibitor Microscopy Nile Pandemics Prevent prevented Protein Proteins reduced SARS-CoV-2 Sec61 shown Spike protein tested the spike protein translocation transmission electron microscopy vesicles Viral viral infection Viral protein viral replication virus West Zika [DOI] 10.1021/acsinfecdis.2c00008 PMC 바로가기 [Article Type] Article
Structural basis for inhibition and regulation of a chitin synthase from Candida albicans Research Published on 2022-07-042022-10-05 Journal: Nature Structural & Molecular Biology [Category] 변종, [키워드] binding Candida albican chitin conserved Control cryo-EM structure enzyme activity Extracellular fungal cell wall inhibitor mechanism membrane motif non-specific Prevent Regulation Synthase target translocation unique [DOI] 10.1038/s41594-022-00791-x [Article Type] Research
Characterization of the Interaction Between SARS-CoV-2 Membrane Protein (M) and Proliferating Cell Nuclear Antigen (PCNA) as a Potential Therapeutic Target잠재적 치료 표적으로서 SARS-COV-2 막 단백질 (M)과 증식 세포 핵 항원 (PCNA) 사이의 상호 작용의 특성화Article Published on 2022-05-232022-08-31 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, [키워드] addition association Cell characterization Coronaviridae family COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 therapy cytoplasm DNA DNA damage DNA replication expression function immunofluorescence immunohistochemistry immunoprecipitation in vitro increase in infected with SARS-CoV-2 Interaction ligation Localization lung M protein marker membrane protein nucleus PCNA Potential reduction repair reported responsible SARS-CoV-2 target the Coronaviridae therapy transfected with translocation Transport Verdinexor viral-host interaction virion virus [DOI] 10.3389/fcimb.2022.849017 PMC 바로가기 [Article Type] Article