Drug-Drug Interactions between COVID-19 and Tuberculosis Medications: A Comprehensive Review of CYP450 and Transporter-Mediated EffectsReview Published on 2024-08-062024-09-05 Journal: Pharmaceuticals [Category] update2024, [키워드] Anti-tuberculosis COVID-19 Drug-drug interactions enzyme transporter [DOI] 10.3390/ph17081035 PMC 바로가기 [Article Type] Review
The structure of Plasmodium falciparum multidrug resistance protein 1 reveals an N-terminal regulatory domainArticle Published on 2023-08-082024-08-28 Journal: Microbial Cell Factories [Category] 말라리아, [키워드] drug resistance malaria Pfmdr1 Regulation transporter
Tyrosine 146 of the Human Na+/Taurocholate Cotransporting Polypeptide (NTCP) Is Essential for Its Hepatitis B Virus (HBV) Receptor Function and HBV Entry into HepatocytesArticle Published on 2022-06-092023-06-13 Journal: Viruses [Category] B형 간염, [키워드] bile acid HBV Infection Mutation NTCP PreS1 receptor transporter [DOI] 10.3390/v14061259 PMC 바로가기
Characterization of a novel pesticide transporter and P-glycoprotein orthologues in Drosophila melanogasterArticle Published on 2022-05-252024-08-28 Journal: Proceedings of the Royal Society B: Biological Sciences [Category] 말라리아, [키워드] Drosophila P-glycoprotein pesticides transporter
Hypothesis: Emerging Roles for Aryl Hydrocarbon Receptor in Orchestrating CoV-2-Related Inflammation †Review Published on 2022-02-132022-10-31 Journal: Cells [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] ACE-2 adaptive angiotensin Apoptosis aryl Aryl hydrocarbon receptor AT1 binding boost build COVID-19 disease enzyme expression growth hydrocarbon IFN-I IL-6 immune tolerance Immunity Indolamine induce Inflammation Inflammatory Inflammatory response inflammatory state inhibitory innate response interferon Kynurenine limit management mechanism modulation Neutral pathogenic regulate respiratory Respiratory system role SARS-CoV-2 syndrome T cell target therapeutic target These data transporter Tryptophan type I [DOI] 10.3390/cells11040648 PMC 바로가기 [Article Type] Review
Channels and Transporters of the Pulmonary Lamellar Body in Health and DiseaseReview Published on 2021-12-242022-10-31 Journal: Cells [Category] COVID-19, SARS, [키워드] acidic pH Alveolar Type II alveolus ambroxol ATII ATP Cell channel clearance complex deficiency disease distress Exocytosis expressed form function innate immune system Ivermectin lack Lamellar Body Ligand Lipid lung lysosome related organelle (LRO) maintain membrane organelle organism Pathogens pathway Proteins pulmonary purinergic signaling receptors reduction responsible SARS-CoV-2 secretion surfactant syndrome tension therapeutic targets transporter viral infection [DOI] 10.3390/cells11010045 PMC 바로가기 [Article Type] Review
Interactions of anti-COVID-19 drug candidates with hepatic transporters may cause liver toxicity and affect pharmacokineticsArticle Published on 2021-09-082022-10-04 Journal: Scientific Reports [Category] SARS, 치료제, [키워드] Affect Apical basolateral basolateral membrane blood stream Cell Biology clearance co-morbidities Compound Concentration COVID-19 dependent on Diseases drug candidate Drug discovery examined expel Favipiravir had no hepatocytes human liver in vitro inhibited inhibiting inhibitory Interaction Ivermectin liver Lopinavir membrane metabolism promote Remdesivir reported Repurposed drug Ritonavir significant effect Toxicity transporter treat Treatment venous viral disease xenobiotics [DOI] 10.1038/s41598-021-97160-3 PMC 바로가기 [Article Type] Article
ADME and Pharmacokinetic Properties of Remdesivir: Its Drug Interaction PotentialReview Published on 2021-07-082022-10-28 Journal: Pharmaceuticals [Category] COVID-19, [키워드] activated ADME antiviral activity beta coronavirus Carboxylesterases caused clinician Comorbidities Complication coronavirus 2 COVID-19 COVID-19 patients COVID-19 treatment guideline cytochrome P450 distribution domain drug drug interaction drug regimen drug-drug interaction Ebola virus enzyme evaluated future work global pandemic Healthcare systems information lack medication metabolism metabolite nucleotide P450 pandemic pharmacokinetics Potential Prevent property Remdesivir Replication reported respiratory RNA SARS-CoV-2 tested the SARS-CoV-2 therapeutic transporter Treatment treatment regimens WHO World Health Organization [DOI] 10.3390/ph14070655 PMC 바로가기 [Article Type] Review
Functional-genomic analysis reveals intraspecies diversification of antiviral receptor transporter proteins in Xenopus laevis기능 게놈 분석은 Xenopus laevis에서 항바이러스 수용체 수송체 단백질의 종 내 다양화를 보여줍니다Research Article Published on 2021-05-202022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] African African clawed frog Analysis Antiviral assays clade described effector Evolution expression family functional G-protein homolog identify immune immune stimulation independent Infection inhibit Innate immunity involved knowledge less mammal Mammalia mammalian mammals MOST Olfaction olfactory physiological Positive selection Protein receptor regulate reveal RNA sequencing RNA viruses Signaling transporter upregulated vertebrates Viral viral infection Xenopus [DOI] 10.1371/journal.pgen.1009578 PMC 바로가기 [Article Type] Research Article
B 0 AT1 Amino Acid Transporter Complexed With SARS-CoV-2 Receptor ACE2 Forms a Heterodimer Functional Unit: In Situ Conformation Using Radiation Inactivation AnalysisOriginal Research Published on 2021-05-132022-10-31 Journal: Function (Oxford, England) [Category] COVID-19, SARS, [키워드] 6M17 accompanied ACE2 acid Amino acid amino acid transporter angiotensin-converting enzyme-2 apical membrane approach AT1 B0AT1 coexpressed complex component conformation contribute COVID-19 COVID-19 patients dose Enterocyte expressed expression form functional Gut human tissues indicated Interaction intestine linear magnitude membrane membrane vesicle membranes mitigate molecular docking molecular weight Neutral neutral amino acid transport obligatory outbreak Particles persistence physiological purified Radiation radiation inactivation reported SARS-CoV-2 SARS-CoV-2 receptor small intestine sodium-dependent transport Symptom translational Transport transporter treat variant virion [DOI] 10.1093/function/zqab027 PMC 바로가기 [Article Type] Original Research