The augmented synthetic control method in public health and biomedical researchOriginal Research Article Published on 2024-02-062024-09-05 Journal: Statistical Methods in Medical Research [Category] update2024, [키워드] Causal inference comparative case studies counterfactual Synthetic control treatment effect [DOI] 10.1177/09622802231224638 PMC 바로가기 [Article Type] Original Research Article
Effectiveness and safety of azvudine in older adults with mild and moderate COVID-19: a retrospective observational studyResearch Published on 2024-01-042024-09-05 Journal: BMC Infectious Diseases [Category] update2024, [키워드] Azvudine COVID-19 Nirmatrelvir/ritonavir Older adults treatment effect [DOI] 10.1186/s12879-023-08944-z PMC 바로가기 [Article Type] Research
Coronavirus disease 2019 subphenotypes and differential treatment response to convalescent plasma in critically ill adults: secondary analyses of a randomized clinical trialArticle Published on 2022-11-012022-11-15 Journal: Intensive care medicine [Category] Fulltext, MERS, 바이오마커, [키워드] ABO-compatible convalescent plasma Adaptive platform trial Adults Analysis assigned Biomarker Biomarkers chemokines community-acquired pneumonia convalescent plasma Convalescent plasma therapy coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient Critically ill critically ill patients Cytokines difference effector immune responses elevated endothelial explain heterogeneous homogeneous Hypothesis immunologically immunotherapies Inflammation IQR median multifactorial organ support outcome outcomes patients Population precision medicine Prevalence Randomized randomized clinical trial RCT RCTs REMAP-CAP reported secondary analysis Subphenotypes. tested therapy treatment effect Treatment response usual care with COVID-19 [DOI] 10.1007/s00134-022-06869-w PMC 바로가기
Comparative effectiveness of neutralising monoclonal antibodies in high risk COVID-19 patients: a Bayesian network meta-analysisArticle Published on 2022-10-202022-11-15 Journal: Scientific Reports [Category] COVID19(2023년), meta-analysis, SARS, 변종, 진단, [키워드] absolute reduction article baseline Bayesian comparable Comparative COVID-19 Effect effective Effectiveness Efficacy Evidence expected generalisability healthcare high risk hospitalisation ICU admission identify individual infected individual infected with SARS-CoV-2 invasive ventilation moderate monoclonal antibody Mortality network Network meta-analysis neutralising outcome Pairwise comparison patient population patients patients treated Placebo predict Rate RCT reaction reduce mortality reducing reduction in relative risk risk reduction serious AE severe COVID-19 statistically significant reduction systematic review therapy treatment effect vaccination variant [DOI] 10.1038/s41598-022-22431-6 PMC 바로가기
Palmitoylethanolamide Reduces Proinflammatory Markers in Unvaccinated Adults Recently Diagnosed with COVID-19: A Randomized Controlled TrialArticle Published on 2022-10-062022-11-15 Journal: The Journal of Nutrition [Category] COVID19(2023년), SARS, 바이오마커, [키워드] adhesion molecules age anti-inflammatory effect Antigen assigned baseline Biomarker Blood BMI C-reactive protein CDC chronic condition coin toss Concentration conducted Controlled coronavirus disease covariates COVID-19 COVID-19 complications COVID-19, SARS-COV-2 Cytokines diagnosed with COVID-19 Diagnosis dietary supplements double-blind dysregulated immune response Effect exacerbate ferritin group Health IL-1β IL-2 IL-6 implicated indicated individual infected with COVID-19 infections infectious conditions Inflammation inflammatory mediator intercellular Linear regression model mechanism Multiple outcomes P-selectin palmitoylethanolamide participant Placebo placebo tablet positive test result Primary outcome produced proinflammatory promote randomized placebo-controlled trial Randomly receive reduced reported RT-PCR secretion severity Sex significantly stratified treatment effect [DOI] 10.1093/jn/nxac154 PMC 바로가기
Interferon α-2b spray shortened viral shedding time of SARS-CoV-2 Omicron variant: An open prospective cohort study인터페론 α-2b 스프레이는 SARS-CoV-2 오미크론 변이체의 바이러스 배출 시간을 단축: 공개 전향 코호트 연구Article Published on 2022-08-052022-09-11 Journal: Frontiers in Immunology [Category] SARS, 변종, 치료제, [키워드] 95% CI administration adverse effect against SARS-CoV Analysis antiviral activity China Cohort cohort study control group COVID-19 Effect Effectiveness enrolled examined experimental group first positive IFN IFN α IFN α-2b spray interferon less omicron Omicron variant participant Patient prospective cohort study protective effect protective factor SARS-CoV-2 SARS-CoV-2 Omicron variant SARS-CoV-2 variant Shanghai shown significantly spray Spread subgroup analysis the median treatment effect treatment effects univariate Cox regression univariate Cox regression analysis Vaccine viral shedding viral shedding time virus clearance virus transmission [DOI] 10.3389/fimmu.2022.967716 PMC 바로가기 [Article Type] Article
A telerehabilitation programme in post-discharge COVID-19 patients (TERECO): a randomised controlled trialRandomized Controlled Trial Published on 2022-07-012022-10-05 Journal: Thorax [Category] 임상, [키워드] 1:1 95% CI aerobic Block randomisation China COVID-19 COVID-19 patient demonstrated Dyspnoea Effect Exercise capacity Follow-up form greater hospital hospitalised increase Jiangsu lower limb muscle Lung function maximum voluntary ventilation outcome physical Pulmonary function pulmonary rehabilitation Quality of life randomised randomised controlled trial rehabilitation secondary survivor Thoracic treatment effect Trial walking distance were assessed [DOI] 10.1136/thoraxjnl-2021-217382 PMC 바로가기 [Article Type] Randomized Controlled Trial
Automated interpretable discovery of heterogeneous treatment effectiveness: A COVID-19 case studyResearch article Published on 2022-06-012022-10-05 Journal: Journal of biomedical informatics [Category] 치료법, [키워드] approach automated automatically benefit combinatorial treatment COVID-19 COVID-19 case dataset Effectiveness Evidence expected Factor heterogeneous Heterogeneous Treatment Effects Hierarchical ICU patient in-hospital mortality Inflammation Interpretable Machine Learning methodology Patient patients hospitalized Personalized medicine predicted predictive power predictor provide risk risk factor Testing thrombosis Treatment treatment effect Treatment effectiveness treatment effects [DOI] 10.1016/j.jbi.2022.104086 [Article Type] Research article
Agreement of treatment effects from observational studies and randomized controlled trials evaluating hydroxychloroquine, lopinavir-ritonavir, or dexamethasone for covid-19: meta-epidemiological study코로나19에 대한 히드록시클로로퀸, 로피나비르-리토나비르 또는 덱사메타손을 평가하는 관찰 연구 및 무작위 대조 시험의 치료 효과 일치: 메타 역학 연구Article Published on 2022-05-102022-09-11 Journal: The BMJ [Category] meta-analysis, 임상, [키워드] age agreement Analysis calculated Clinical data collected Comparisons complement conducted controlled trials COVID-19 treatment criteria data extraction database demographical and clinical data demographics Dexamethasone disease severity distribution Efficacy Epidemiological study evaluated Evidence Hydroxychloroquine identify independent Lopinavir Lopinavir-ritonavir Matched means Medicine meta-analysed meta-analyses Meta-analysis Network meta-analysis nine not significant observational studies observational study outcome outcomes overlapping Placebo PLOS proportion Randomized controlled trial RCT RCTs reported Ritonavir Safety sequential analysis Seven Sex significantly synthesis systematic review therapeutic intervention therapeutic interventions Treatment treatment effect treatment effects trial sequential analysis [DOI] 10.1136/bmj-2021-069400 PMC 바로가기 [Article Type] Article
COVID-19 Pandemic and Exercise (COPE) trial: a multigroup pragmatic randomised controlled trial examining effects of app-based at-home exercise programs on depressive symptomsRandomized Controlled Trial Published on 2022-05-012022-10-05 Journal: British journal of sports medicine [Category] 임상, [키워드] Analysis baseline Canadian COPE COVID-19 COVID-19 pandemic Depression depressive symptom Depressive symptoms Effect effect size exercise four groups General population global public health globe group growth implication IMPROVE intensity mental health not significantly different pandemic participant Participants populations Pragmatic promotion randomisation randomised randomised controlled trial reduce significantly Support Symptom treatment effect were measured yoga [DOI] 10.1136/bjsports-2021-104379 PMC 바로가기 [Article Type] Randomized Controlled Trial