Handling death as an intercurrent event in time to recovery analysis in COVID-19 treatment clinical trialsResearch article Published on 2022-08-012022-10-05 Journal: Contemporary clinical trials [Category] 임상, 치료법, [키워드] Analysis clinical trial competing competing risk conducted COVID-19 death detect died discharged evaluate Follow-up handling hospital hospitalized patients moderate mortality risk nine parameter Patient proportion raise reconstructed Research risk survival survival analysis the patient therapy time to event Time to recovery treat Treatment treatment trials Trial [DOI] 10.1016/j.cct.2022.106758 [Article Type] Research article
Exclusion of Reproductive-Aged Women in COVID-19 Vaccination and Clinical TrialsResearch article Published on 2022-06-012022-10-05 Journal: Women's Health Issues [Category] COVID19(2023년), SARS, 신약개발, 임상, [키워드] Analysis analyzed association Breastfeeding childbearing potential clinical Clinical treatment clinical trial clinical trials Contraception coronavirus disease COVID-19 COVID-19 vaccination COVID-19 vaccine database excluded exclusion exclusion criteria global pandemic individual individuals lactating lactation library male Medicine participant Pregnancy pregnant profiles required Result Sponsor study participation Treatment treatment trials trials Vaccine [DOI] 10.1016/j.whi.2022.06.004 [Article Type] Research article
Improving precision and power in randomized trials for COVID-19 treatments using covariate adjustment, for binary, ordinal, and time-to-event outcomes공변량 조정을 사용하여 이항, 순서 및 사건 발생까지의 시간 결과에 대한 COVID-19 치료에 대한 무작위 시험의 정밀도 및 검정력 향상Article Published on 2021-12-012022-09-11 Journal: Biometrics [Category] SARS, 임상, [키워드] added Analysis approach center clinical trials ClinicalTrials Control covariate covariate adjustment COVID-19 COVID-19 treatment disease control distribution drug Drug administration essence European Medicines Agency food hypothetical implementation IMPROVE Improving Inference Longitudinal data Medicine New York ordinal outcomes outcome Participants patients hospitalized Phase 2 Precision prevention prevention of COVID-19 Primary outcome R package Randomized randomized clinical trial randomized trial randomized trials recommendation reduce reductions in Registered required Sample size sample sizes Standard of care statistical analysis survival survival analysis targets time Treatment treatment trials treatments for COVID-19 Trial trials Two-arm U.S. Food and Drug Administration variety [DOI] 10.1111/biom.13377 PMC 바로가기 [Article Type] Article
Cancer Clinical Trial Participation at the 1-Year Anniversary of the Outbreak of the COVID-19 Pandemic코로나19 팬데믹 발생 1주년 기념 암임상시험 참가Research Published on 2021-07-292022-09-10 Journal: JAMA Network Open [Category] 임상, [키워드] 95% CI actual age Analysis anniversary apex Black patient Black patients Cancer CCP change clinical Clinical research clinical trial cohort study conducted COVID-19 COVID-19 outbreak COVID-19 pandemic death decrease Effect enrolled Enrollment estimate Evidence evidence of expected exposure female patient finding Hispanic patient Hispanic patients Importance include initial landmark measure MOST network objective occurred Older outbreak over pandemic participant Participation Patient patients Point protocol protocols question reduction reduction in Relative risk Relevance remained representing Research Result setting SWOG treatment trial treatment trials Trial trials variable Winter worsened [DOI] 10.1001/jamanetworkopen.2021.18433 PMC 바로가기 [Article Type] Research
Ivermectin for Prevention and Treatment of COVID-19 Infection: A Systematic Review, Meta-analysis, and Trial Sequential Analysis to Inform Clinical GuidelinesCOVID-19 감염 예방 및 치료를 위한 Ivermectin: 임상 지침을 제공하기 위한 체계적인 검토, 메타 분석 및 시험 순차 분석Meta-Analysis Published on 2021-06-212022-09-11 Journal: American journal of therapeutics [Category] SARS, 치료제, [키워드] 95% confidence interval adverse event Analysis anti-inflammatory properties antiparasitic Antiviral approach Area average average risk benefit certainty Chemoprophylaxis clinical Clinical course clinical trials conducted COVID-19 COVID-19 infection database death Deterioration Efficacy estimate Evidence evidence of guideline high risk Inclusion Ivermectin ivermectin treatment less mechanical ventilation Medicine meta-analyses Meta-analysis Mortality no difference outcome pandemic participant prevention Prophylaxis provided Randomized controlled trial reduce reduced reduced risk reducing mortality reductions in review Risk of bias risk ratio robust SARS-CoV-2 pandemic SARS-CoV-2 virus searched secondary secondary outcome Secondary outcomes sequential analysis severe adverse events severe disease suggested tested the SARS-CoV-2 the SARS-CoV-2 virus treatment trial treatment trials Trial trial sequential analyses trial sequential analysis [DOI] 10.1097/MJT.0000000000001402 PMC 바로가기 [Article Type] Meta-Analysis
Cross-linking peptide and repurposed drugs inhibit both entry pathways of SARS-CoV-2가교 펩타이드 및 용도 변경 약물은 SARS-CoV-2의 두 진입 경로를 모두 억제합니다Article Published on 2021-03-092022-08-31 Journal: Nature Communications [Category] SARS, 신약개발, 치료제, [키워드] Antiviral approach Arbidol camostat cells Chloroquine cocktail Combination coronavirus Coronaviruses COVID-19 COVID-19 treatment Cross-linking drug combination Drug discovery effective Endocytic pathway Endosomal acidification ENhance entry pathway hamster hamsters identify in vitro in vivo inhibit inhibit SARS-CoV-2 inhibiting inhibitor mice pathway peptide Repurposed drug Repurposed drugs SARS-CoV SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 virus significantly suppress suppresse therapy TMPRSS2 TMPRSS2 inhibitor today treating COVID-19 Treatment treatment trial treatment trials umifenovir Viral viral replication virus entry [DOI] 10.1038/s41467-021-21825-w PMC 바로가기 [Article Type] Article
Inclusion of pregnant women in COVID-19 treatment trials: a review and global call to actionCOVID-19 치료 시험에 임산부 포함: 검토 및 글로벌 행동 촉구Review Published on 2021-03-012022-09-11 Journal: The Lancet. Global health [Category] Fulltext, SARS, 임상, 치료법, [키워드] Chloroquine Clinical treatment clinical trial clinical trial registry clinical trials Corticosteroids COVID-19 criterion drug during pregnancy effective effective therapy evaluated excluded exclusion Health High-dose Hydroxychloroquine identify IMPROVE Inclusion interferon beta International Ivermectin Lopinavir Lopinavir-ritonavir outcomes Pregnancy pregnant women proportion recommendation Remdesivir Ritonavir timepoint Treatment treatment for COVID-19 treatment trial treatment trials Trial Vitamin [DOI] 10.1016/S2214-109X(20)30484-8 PMC 바로가기 [Article Type] Review
Pediatric Inflammatory Multisystem Syndrome: Statement by the Pediatric Section of the European Society for Emergency Medicine and European Academy of PediatricsPediatrics Published on 2020-08-282022-10-31 Journal: Frontiers in Pediatrics [Category] COVID-19, [키워드] Academy America aneurysms anti-TNF appear arteries Care children Consensus COVID-19 Critical care differential diagnoses disease early stage Emergency Escalation Europe European Evidence febrile Fever Hyperinflammatory hypovolaemia Immunoglobulin incidence include infection with SARS-CoV-2 Infectious disease Inflammation Kawasaki-like disease Limited Medicine MIS-C MOST Multiorgan pediatric pediatrics PIMS-TS Prevent reported Research SARS-CoV-2 secondary care Section Severe case severity Shock Society state Steroids Suspected Symptom treated treatment trials [DOI] 10.3389/fped.2020.00490 PMC 바로가기 [Article Type] Pediatrics