Interleukin-21 modulates balance between regulatory T cells and T-helper 17 cells in chronic hepatitis B virus infectionarticle Published on 2023-10-242024-09-05 Journal: BMC Infectious Diseases [Category] update2024, [키워드] Chronic hepatitis B virus infection IL-21 STAT3 Th17 cells Treg cells [DOI] 10.1186/s12879-023-08723-w PMC 바로가기 [Article Type] article
PD-1 and ICOS counter-regulate tissue resident regulatory T cell development and IL-10 production during fluArticle Published on 2022-09-082022-11-15 Journal: Frontiers in Immunology [Category] 바이오마커, [키워드] accumulated CD4 Cell characterized co-stimulatory receptor COVID Critical Express expressed flu fluorescent FOXP3 GFP heterogenous human population iCoS IL-10 Immune homeostasis immunopathology in vivo Infection infections Influenza influenza infection influenza infections labeling lung tissue memory T cells molecular feature PD-1 proinflammatory promote Regulatory Regulatory T cell repeated reporter respiratory infectious disease response reveal secondary infections shown Signaling signaling pathway suppress T cell T cell response T cells tissue tissue repair tissue resident T cells. transcription factor Treg Treg cell Treg cells Tuberculosis [DOI] 10.3389/fimmu.2022.984476 PMC 바로가기
[Effects of hepatitis B virus on Th17, Treg and Th17/Treg ratio in different alanine aminetransferase stages]Article Published on 2022-04-182023-06-12 Journal: Beijing da xue xue bao. Yi xue ban = Journal of Pe [Category] B형 간염, [키워드] Chronic Hepatitis B Th17 cells Treg cells Viral load [DOI] 10.19723/j.issn.1671-167X.2022.02.012 PMC 바로가기
Foxp3 + CD4 + regulatory T cells control dendritic cells in inducing antigen-specific immunity to emerging SARS-CoV-2 antigensFoxp3 + CD4 + 조절 T 세포는 새로운 SARS-CoV-2 항원에 대한 항원 특이적 면역을 유도하는 수지상 세포를 제어합니다Research Article Published on 2021-12-092022-09-10 Journal: PLoS Pathogens [Category] SARS, 변종, [키워드] absence activate activating acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive Adaptive immune response adaptive immune responses adjuvant adjuvants Administered administration antibody Antigen antigens approach Autoimmune diseases B cell responses CD4 CD8 cells cellular immunity Combination coronavirus DCs dendritic cell dendritic cells draining lymph node draining lymph nodes effective Efficacy ENhance examined expressing follicular FOXP3 Germinal center help helper T cell highlight humoral immune response immune responses Immunity immunological immunological tolerance IMPROVE induce initiated interferon interferon-γ investigated live SARS-CoV-2 lymph nodes maturation mechanisms mice naïve T cells neutralized Neutralizing antibodies neutralizing antibody present antigen prevented produced Protective receptor Regulatory respiratory response responses SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 antigens SARS-CoV-2 spike protein SARS-CoV-2 variants self-tolerance severe acute respiratory syndrome Coronavirus Spike protein stimulate suppress T cell T cells therapy These data transcription factor Transient Treg Treg cell Treg cells vaccination Vaccine variants [DOI] 10.1371/journal.ppat.1010085 PMC 바로가기 [Article Type] Research Article
Site-specific PEGylation of interleukin-2 enhances immunosuppression via the sustained activation of regulatory T cells Research Published on 2021-09-272022-10-05 Journal: Nature biomedical engineering [Category] 치료제, [키워드] Activation activation and expansion Amino acid Arthritis Autoimmune diseases bind binding Cell cytokine defined disease dose ENhance glycol Host IL-2 IL-2 receptor immune Immunosuppression injection mouse model PEGylation Regulatory Regulatory T cell selective Subcutaneous sustained therapeutic therapeutic efficacy therapeutic window Treatment Treg Treg cells trimeric viral infection [DOI] 10.1038/s41551-021-00797-8 [Article Type] Research
The Role of Th17 Response in COVID-19Review Published on 2021-06-192022-10-31 Journal: Cells [Category] COVID-19, MERS, SARS, [키워드] activating acute infectious disease cascade caused colony stimulating factor coronavirus 2 counterproductive Course COVID-19 COVID-19 pneumonia cytokine Cytokines Defense droplet Evidence G-CSF granulocyte hospitalised IL-10 IL-17 IL-2 IL-6 IL-7 IL-8 ill patient immune response immune system Increasing Infection inhibiting interleukin MCP-1 monocyte Necrosis occur pathogenesis of COVID-19 Protein respiratory Respiratory system response role SARS-CoV-2 SARS-COV-2 infection target Th1 Th17 Th17 cell Th17 pathway Th17 response Th2 responses the SARS-CoV-2 virus therapeutic intervention TNF Treg cells viral infection with COVID-19 [DOI] 10.3390/cells10061550 PMC 바로가기 [Article Type] Review
Immunosuppression as a Hallmark of Critical COVID-19: Prospective StudyArticle Published on 2021-05-232022-10-31 Journal: Cells [Category] COVID-19, SARS, [키워드] adaptive Admission analyzed B cells Cell cells Clinical deterioration Clinical outcome comprehensive analysis Course COVID-19 COVID-19 patient COVID-19 patients Critical Critically ill Cytokines dysregulation hospital Hospitalization ICU IL-2 IL-2/INFγ ratio Immunosuppression immunosuppressive impaired function INFγ Infection leukocyte lymphocyte subpopulation Lymphocyte subsets naïve NK cell NK cells non-ICU outcome outcomes Patient patients with COVID-19 performed Peripheral blood predict Prospective reductions in regulatory T cells required response SARS-CoV-2 SARS-COV-2 infection secreted subpopulations subsequent T cell T cells TCR γ/δ cells TCRα/β the disease the SARS-CoV-2 TNFα Treg cell Treg cells [DOI] 10.3390/cells10061293 PMC 바로가기 [Article Type] Article
Reduced frequency of T helper 17 and T helper 1 cells and their association with critical coronavirus disease 2019T 헬퍼 17 및 T 헬퍼 1 세포의 빈도 감소 및 중요한 코로나바이러스 질병 2019와의 연관성Article Published on 2021-05-012022-09-12 Journal: Apmis [Category] SARS, 진단, [키워드] association Cell cellular immunity Control coronavirus disease Coronavirus disease 2019 COVID-19 Critical critical COVID-19 patient difference disease dysregulated evaluate flow cytometry Frequency healthy controls healthy subject immune responses knowledge moderate-to-severe patient not significant Patient Peripheral blood severity of COVID-19 significant difference significantly subject Subtypes T helper T helper 1 T helper 17 Th1 Th17 Th17 cell Treg Treg cell Treg cells were measured [DOI] 10.1111/apm.13129 PMC 바로가기 [Article Type] Article
Lymphopenia, Lymphopenia-Induced Proliferation, and AutoimmunityReview Published on 2021-04-162023-06-12 Journal: International Journal of Molecular Sciences [Category] MERS, [키워드] Autoimmunity Immune aging lymphopenia-induced proliferation Tolerance Treg cells [DOI] 10.3390/ijms22084152 PMC 바로가기 [Article Type] Review
The role of CD4 + FoxP3 + regulatory T cells in the immunopathogenesis of COVID-19: implications for treatmentCOVID-19의 면역 병인 발생에서 CD4 + FoxP3 + 조절 T 세포의 역할: 치료에 대한 의미Review Published on 2021-04-102022-08-31 Journal: International Journal of Biological Sciences [Category] MERS, SARS, 바이오마커, [키워드] “cytokine storm” acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus adalimumab addressed Antiviral ARDS attenuation Azithromycin CD4 CD4+FoxP3+ regulatory T cells Chloroquine Coagulopathy coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cytokine Cytokine release syndrome Cytokine storm Defense deficiencies deficiency Dexamethasone early stage FOXP3 Hydroxychloroquine IL-2 immune Immune homeostasis immune response immune responses Immunopathogenesis immunopathology implication Infection Inflammatory responses introduced involved late stage low dose maintenance mechanisms organ damage organ injury Patient Perspective problem problems Regulatory Regulatory T cell regulatory T cells respiratory respiratory distress Respiratory distress syndrome sarilumab SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Severe case severe cases syndrome T cell T cells tetrandrine therapeutic agent therapeutic agents Therapies Tocilizumab transfer Treatment Treg Treg cell Treg cells Tregs Vitamin D [DOI] 10.7150/ijbs.59534 PMC 바로가기 [Article Type] Review