Global Regulatory and Public Health Initiatives to Advance Pediatric Drug Development for Rare DiseasesArticle Published on 2022-11-012022-11-16 Journal: Therapeutic innovation & regulatory science [Category] 신약개발, [키워드] advance affected approach children clinical trials COVID-19 COVID-19 pandemic development disease drug ecosystem Efficacy effort engage equity facilitate Follow-up include initiative key factor lack outcome measure Patient pediatric pediatric drug development promote Public public health rare disease rare diseases Regulatory Regulatory policy. Study design Therapies Trial trials [DOI] 10.1007/s43441-022-00409-w PMC 바로가기
‘Mix and Match’ vaccination: Is dengue next?Article Published on 2022-10-262022-11-15 Journal: Vaccine [Category] COVID19(2023년), SARS, 진단, [키워드] 'Mix and match' Antigen approach benefit boost breadth cellular Cellular responses Combination COVID-19 COVID-19 pandemic demonstrated Dengue dengue virus Dengvaxia dose effective Efficacy evaluated help Heterologous HIV homologous Human Humoral immunity Immunity immunization Impact Increased immunogenicity induce match overcome priming reactogenicity regimen reported response SARS-CoV-2 SARS-CoV-2 vaccine sequence severity significantly study participant T cell TAK-003 the vaccine Trial trials TV003 vaccination Vaccine vaccine. Vaccines [DOI] 10.1016/j.vaccine.2022.09.007 PMC 바로가기
Randomized, Double-Blind, Placebo-Controlled Trial of a Throat Spray with Selected Lactobacilli in COVID-19 OutpatientsArticle Published on 2022-10-262022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] acting acute respiratory syndrome added Administered administration Amplicon sequencing analyses Analysis antibody Antiviral antiviral property antiviral strategy applied Bacteria benefit Care chills collected Combined coronavirus coronavirus disease COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients detectable Diagnosis diarrhea double-blind dried blood spot eligible evaluated Fever Health hospital Hospitalization infected with SARS-CoV-2 Lactobacillaceae lactobacilli Microbiome modulation multifactorial nasopharyngeal viral load nose-throat swab online questionnaire Outpatient Pain Patient per-protocol analysis Placebo placebo-controlled trial positive potential mechanism practitioners qPCR quantitative PCR Randomized reduce reducing reported reported symptom respiratory tract infection respiratory viral disease SARS-CoV-2 selected sequence severity significantly spray strain Symptom symptom resolution the patient the placebo group therapy Throat throat spray. Treatment Trial trials upper respiratory tract Vaccines variant Viral diseases viral infection Viral load was performed [DOI] 10.1128/spectrum.01682-22 PMC 바로가기
Comparison of the safety and immunogenicity of the BNT-162b2 vaccine and the ChAdOx1 vaccine for solid organ transplant recipients: a prospective studyArticle Published on 2022-10-132022-11-15 Journal: BMC Infectious Diseases [Category] COVID19(2023년), SARS, 진단, [키워드] acute respiratory syndrome administration anti-RBD antibody BNT-162b2 ChAdOx1 vaccine coronavirus coronavirus disease COVID-19 diabetes disease dose doses Effect Efficacy first dose IgG Immunity vaccine Immunoglobulin Infection kidney kidney transplant liver liver transplant Liver transplant. Local no difference older patient Organ transplant Patient platform Primary outcome Prospective Study prospectively studied question recipient reduced resulting SARS-CoV-2 SARS-CoV-2 vaccination second dose secondary endpoint seroconversion rate shown side significantly solid organ transplant spread to systemic adverse event the RBD the spike protein the vaccine trials unresponsiveness vaccination Vaccine vaccine doses vaccine platform [DOI] 10.1186/s12879-022-07764-x PMC 바로가기
Care for adults with COVID-19: living guidelines from the National COVID-19 Clinical Evidence TaskforceArticle Published on 2022-10-032022-11-15 Journal: The Medical journal of Australia [Category] COVID19(2023년), SARS, 진단, [키워드] Analysis anticoagulation Antiviral agents Baricitinib benefit change clinical clinical trial Combination coronavirus disease Corticosteroids COVID-19 disease disease severity drug treatment eight Endotracheal intubation Evidence facilitated Health include Inhaled maintain management Mild molnupiravir nine Patient people with COVID-19 positive airway pressure Primary Health Care prone positioning Prophylactic Prophylaxis Public public health. randomised recommendation recommendations Remdesivir Respiratory Support sarilumab subsequent supplemental oxygen Support supportive care systemic corticosteroids therapy Tocilizumab Treatment trials Venous Thromboembolism with COVID-19 [DOI] 10.5694/mja2.51718 PMC 바로가기
NVX-CoV2373 vaccination induces functional SARS-CoV-2-specific CD4+ and CD8+ T cell responsesArticle Published on 2022-10-032022-11-15 Journal: The Journal of Clinical Investigation [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] Adaptive immunity CD4+ CD4+ T cell CD4+ T cells CD8+ T cell Cell Cellular immune response characteristic characterization circulating correlated COVID-19 demonstrated detectable dose Efficacy follicular full-length SARS-CoV-2 functional humoral immune responses IFN-γ immune immunization immunology individual induce magnitude Matrix-M NVX-CoV2373 Protective Protein response responses robust SARS-CoV-2-neutralizing antibody spike trimer subset T cells T cells. Th1 cell trials vaccinated individual vaccination Vaccine [DOI] 10.1172/JCI160898 PMC 바로가기
COVID-19 booster uptake among US adults: Assessing the impact of vaccine attributes, incentives, and context in a choice-based experimentResearch article Published on 2022-10-012022-10-05 Journal: Social science & medicine (1982) [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] Administered Affect Assessing attribute attributes booster concern Conjoint experiment contagious COVID-19 COVID-19 vaccine Efficacy experiment Factor Guidance IMPROVE individual information initial less likelihood objective offer omicron predisposition protection provide Public acceptance public health public health messaging rationale receive reported Research Result significantly increased traits trials vaccinate vaccination vaccination against COVID-19 Vaccine variant [DOI] 10.1016/j.socscimed.2022.115277 [Article Type] Research article
Seizures following COVID-19 vaccination in Mexico: A nationwide observational studyArticle Published on 2022-10-012022-11-16 Journal: Epilepsia [Category] COVID19(2023년), SARS, 치료기술, [키워드] Administered administration adverse events approval BNT162b2 conducted COVID-19 COVID-19 pandemic COVID-19 vaccination detect dose effective vaccine epidemiological epilepsy events first dose highest incidence incidence rate Moderna mRNA-1273 Patient patients Pfizer-BioNTech recipient retrospective SARS-CoV-2 SARS-CoV-2 vaccination SARS-CoV-2 vaccine SARS-CoV-2 vaccines Seizure Seizures seizures. Surveillance trials Vaccine [DOI] 10.1111/epi.17390 PMC 바로가기
Are the Current Processes and Regulations Fit for Purpose to Deliver Novel Therapies During Pandemics? A Perspective on COVID-19 from the UKArticle Published on 2022-10-012022-11-16 Journal: Pharmaceutical medicine [Category] 신약개발, [키워드] activities adaptive approval arise contribute country COVID-19 COVID-19 pandemic current develop Dexamethasone ENhance flexible Health involved lesson Medicines multi-arm novel Pandemics question rare diseases RECOVERY trial reduce Regulation Regulatory regulatory pathways shown Stress therapy Trial trials UK Medicine United Kingdom urgency [DOI] 10.1007/s40290-022-00439-7 PMC 바로가기
Recent clinical findings on the role of kinase inhibitors in COVID-19 managementCOVID-19 관리에서 키나제 억제제의 역할에 대한 최근 임상 결과Review Published on 2022-10-012022-09-11 Journal: Life sciences [Category] 변종, 신약개발, 임상, 치료제, [키워드] activator affected alleviate Anti-inflammatory anti-viral effects antiviral agent Antiviral agents BTK clinical evidence Clinical finding Clinical practice clinical trial Complication complications Consequences coronavirus disease COVID-19 COVID-19 patient COVID-19 patients CRS cytokine release storm drug Efficacy glycogen synthase GSK-3 highly pathogenic inhibitor inhibitors JAK/STAT janus Janus kinase kinase Kinase inhibitor kinase inhibitors kinases management MAPK Novel coronavirus novel coronavirus disease outbreak p38 MAPK. pandemic paradigm shift performed pharmacological pharmacological intervention protein kinase recent Signaling STAT therapy Transcription trials Viral load [DOI] 10.1016/j.lfs.2022.120809 PMC 바로가기 [Article Type] Review