Identification of circulating microRNA profiles associated with pulmonary function and radiologic features in survivors of SARS-CoV-2-induced ARDSSARS-CoV-2에 의해 유발된 ARDS 생존자의 폐 기능 및 방사선학적 특징과 관련된 순환 microRNA 프로파일 식별Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 유전자 메커니즘, 임상, [키워드] acute respiratory distress syndrome Anti-inflammatory ARDS association carbon monoxide cell death Chest computed tomography circulating Coagulation Complete composed Computed tomography conducted correlated COVID-19 develop diffusing diffusing capacity distress enrichment analyses enrichment analysis evaluated Evidence evidence of feature Features Follow-up Gene ontology genomes hospital discharge hypoxia identification immune response infected patient infected patients KEGG KEGG pathway Kyoto lung Lung function median microRNA miR-126 miR-146 miR-146a-5p miR-21 miR-9 miRNA miRNA profiles miRNA profiling miRNA signature molecular molecular mechanism molecular mechanisms Pathogenesis pathophysiology pathway Patient patients predicted profile provided Pulmonary function radiologic radiological feature radiological features Random forest respiratory distress Respiratory distress syndrome RT-qPCR SARS-COV-2 infection secondary to Sequelae severe COVID-19 severity survivor to define Total severity score Trial registration TSS vascularization viral infection was performed was used [DOI] 10.1080/22221751.2022.2081615 PMC 바로가기 [Article Type] Article
Hydrothermal deconstruction of single-use personal protective equipment during the COVID-19 pandemicArticle Published on 2022-11-012022-11-15 Journal: Waste management (New York, N.Y.) [Category] SARS, 치료기술, [키워드] acetic adopted ammonia carbon dioxide Concentration Contamination COVID-19 COVID-19 pandemic Fatty acid Hydrothermal deconstruction increase in initial Isolation lowest Masks oxygen Personal protective equipment PPE produced Protective Regulation selected surgical temperature the SARS-CoV-2 virus Transmission TSS was reduced waste waste management Wet Wet oxidation. [DOI] 10.1016/j.wasman.2022.09.006 PMC 바로가기
Multiplex protein profiling of bronchial aspirates reveals disease-, mortality- and respiratory sequelae-associated signatures in critically ill patients with ARDS secondary to SARS-CoV-2 infection기관지 흡인물의 다중 단백질 프로파일링은 SARS-CoV-2 감염에 이차적으로 ARDS가 있는 중환자에서 질병, 사망률 및 호흡기 후유증과 관련된 징후를 나타냅니다.Multicenter Study Published on 2022-07-292022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, 치료기술, [키워드] acute respiratory distress acute respiratory distress syndrome adverse outcomes AGR2 all-cause mortality ARDS association BAS bronchial bronchial aspirate confounding factors correlated COVID-19 COVID-19 patients Cox regression model Cox regression models Critically ill Critically ill patient critically ill patients CST5 Decision making determinant disease pathogenesis DPP7 ENTPD2 expressed Factor FCRL1 highest hospital discharge host response ICU ICU – intensive care unit identify IL-1α immune IMV intensive care Invasive mechanical ventilation Kaplan-Meier curve Kaplan-Meier curves KYAT1 lung cells Lung function mechanism molecular Mortality mortality risk multicenter study NADK Non-COVID-19 Non-COVID-19 patients nonsurvivor nonsurvivors NQO2 NTF4 OSM outcomes Pathogenesis pathology Poor Protein proteomic proteomics proximity extension assay PTN quantified radiological feature radiological features random Random forest reduced respiratory respiratory distress Respiratory distress syndrome reveal risk Risk assessment SARS-COV-2 infection SRPK2 subgroup subgroups supported Survivors the disease the strongest THOP1 TRAIL TSS TYMP Viral viral infectivity were used with COVID-19 [DOI] 10.3389/fimmu.2022.942443 PMC 바로가기 [Article Type] Multicenter Study
Multisystem Inflammatory Syndrome in Children and Long COVID: The SARS-CoV-2 Viral Superantigen Hypothesis소아 및 장기 코로나의 다기관 염증 증후군: SARS-CoV-2 바이러스 초항원 가설Article Published on 2022-07-072022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료기술, [키워드] addition Alter attribute autoantibodies autoantibody autoimmune responses Autoimmunity Bacterial binding Cell change children children with MIS-C circulating computational studies conjunctivitis conserved contribute COVID COVID-19 develop elevated exposure to feature febrile Fever Gastrointestinal glycoprotein Gut high affinity hyperinflammation immune response Immunosequencing Inflammatory inflammatory disease initial Kawasaki disease Long Long COVID MHC class II MHC Class II proteins MIS-C MIS-C multisystem inflammatory syndrome in children motif Multiorgan Neurological complication Neurological complications Neurological symptom Neurological symptoms neuronal neurotoxin neurotoxin-like segment oral mucosa PASC Patient patients pediatric Peripheral blood peripheral blood samples persistence persistent fever Post-acute sequelae of COVID-19 (PASC) prolonged exposure promote Proteins rashes resulting SAgs SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA SARS-CoV-2 spike SARS-CoV-2 virus SEB Sequence analysis serum cytokine levels severity Shock similarity staphylococcal enterotoxin staphylococcal enterotoxin B strawberry strawberry tongue Structure superantigen superantigen-like motif. syndrome systemic hyperinflammation T-cell receptor TCR TCRs the SARS-CoV-2 the SARS-CoV-2 virus Toxic shock Toxic shock syndrome TRBV11-2 triggered TSS unique β variable [DOI] 10.3389/fimmu.2022.941009 PMC 바로가기 [Article Type] Article
Comparison of chest CT severity scoring systems for COVID-19COVID-19에 대한 흉부 CT 중증도 점수 시스템 비교Article Published on 2022-05-012022-09-11 Journal: European Radiology [Category] COVID19(2023년), SARS, 치료기술, [키워드] abnormality Accuracy asked AUC calculated Chest CT Clinical severity Computed tomography Computed tomography, X-ray coronavirus COVID-19 CT chest cutoff value demonstrated diagnostic Diagnostic accuracy discrimination female FIVE highest Interpretation lung lung involvement male observation Patient PCR-confirmed PCR-confirmed COVID-19 pulmonary involvement Quantitative reported Reporting Retrospective study ROC Curve ROC curves SARS-CoV-2 scoring system Severe case severe cases severity significantly specificity statistically significant time tomography TSS X-ray [DOI] 10.1007/s00330-021-08432-5 PMC 바로가기 [Article Type] Article
The SGLT2 inhibitor canagliflozin in heart failure: the CHIEF-HF remote, patient-centered randomized trialRandomized Controlled Trial Published on 2022-04-012022-10-05 Journal: Nature Medicine [Category] Fulltext, MERS, 임상, 진단, [키워드] 95% confidence interval benefit city clinical trial clinical trials conducted diabete diabetes double-blind trial Effect Ejection fraction heart failure IMPROVE inhibitor Interaction pandemic participant Patient Placebo preserved Primary outcome Randomized randomized trial reduced score shifting significantly Sponsor Symptom symptom burden the primary endpoint Total Trial TSS unblinding [DOI] 10.1038/s41591-022-01703-8 PMC 바로가기 [Article Type] Randomized Controlled Trial
Flavonoids for Treating Viral Acute Respiratory Tract Infections: A Systematic Review and Meta-Analysis of 30 Randomized Controlled Trials바이러스성 급성 호흡기 감염 치료를 위한 플라보노이드: 30건의 무작위 대조 시험에 대한 체계적인 검토 및 메타 분석Meta-Analysis Published on 2022-02-162022-09-11 Journal: Frontiers in Public Health [Category] COVID19(2023년), SARS, 임상, [키워드] achievement acute bronchitis acute respiratory tract infection adverse event adverse events Adverse reaction Adverse reactions alleviation alleviation of symptoms analyzed bronchial pneumonia bronchitis BSS changes in clearance common cold complementary and alternative medicine control group Controlled Controlled trial controlled trials COVID-19 duration of illness Efficacy analyses efficacy analysis Efficacy and safety eligible flavonoid flavonoids Hospitalization ICU Identifier incidence infections Influenza intensity limitations mechanical ventilation meta-analyses Meta-analysis Mortality not differ oxygen Patient patients hospitalized performed positive RCT RCTs respiratory respiratory tract infection Respiratory tract infections Result review rhinosinusitis RT-PCR Safe Safety severity sinusitis subject substantial risk suggested Symptom Symptoms systematic review TNF-α tonsillitis tonsillopharyngitis tract treating trials TSS Tumor tumor necrosis tumor necrosis factor tumor necrosis factor-α upper respiratory tract upper respiratory tract infections Viral [DOI] 10.3389/fpubh.2022.814669 PMC 바로가기 [Article Type] Meta-Analysis
Impact of time to intubation on mortality and pulmonary sequelae in critically ill patients with COVID-19: a prospective cohort studyResearch Published on 2022-01-102022-11-01 Journal: Critical Care [Category] COVID-19, SARS, [키워드] 95% CI adjusted hazard ratio affected age Analysis ARDS association chest CT scan Cohort COVID-19 critical COVID-19 patient Critically ill patient critically ill patients delay in intubation Early intubation evaluated Follow-up greater hospital hospital discharge Impact IMV in-hospital mortality increase in Intubated intubation Invasive mechanical ventilation lobe male material mean difference median Mortality Patient Prospective prospective cohort study pulmonary sequelae receiving required respiratory management Respiratory Support Result risk significant increase supplementary material survival TSS with COVID-19 [DOI] 10.1186/s13054-021-03882-1 PMC 바로가기 [Article Type] Research
The Spectrum of Manifestations of Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV2) Infection in Children: What We Can Learn From Multisystem Inflammatory Syndrome in Children (MIS-C)Medicine Published on 2021-10-282022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] absence acute SARS-CoV-2 infection ADE antibody Asymptomatic carrier Can capillary cardiac function children children with MIS-C clinically collected coronavirus disease 19 COVID-19 Critical defined definitive diagnosis develop disease etiology Evidence feature Fever heart failure hemodynamic hemophagocytic lymphohistiocytosis HLH Hospitalization hyperinflammation Hyperinflammatory immunological immunological profile Infection Inflammatory biomarker Inflammatory response Interpretation Isolation Laboratory manifestation mechanism MIS-C molecular Myocardial inflammation myocarditis observation occur organ Pathogenesis Patient patients pediatric positive serology preserved profiles respiratory responsible SARS-CoV2 SARSCoV-2 Severe infection Shock Spectrum symptomatic syndrome the disease toxic TSS Viral load [DOI] 10.3389/fmed.2021.747190 PMC 바로가기 [Article Type] Medicine
Development and appraisal of handwash-wastewater treatment system for water recycling as a resilient response to COVID-19Research article Published on 2021-10-012022-10-05 Journal: Journal of Environmental Chemical Engineering [Category] 치료법, [키워드] activated Adsorption approach biological parameter city Community COVID-19 development discharge E. coli Efficiency eliminated exhibited filtration granular Granular activated carbon handwashing high risk Infection International media physicochemical provide Sand selected treat treated Treatment TSS turbidity Uganda Wastewater treatment Zeolite [DOI] 10.1016/j.jece.2021.106113 [Article Type] Research article