tumor necrosis – Communicable Diseases Research

Epipharyngeal Abrasive Therapy (EAT) Reduces the mRNA Expression of Major Proinflammatory Cytokine IL-6 in Chronic Epipharyngitis

Epipharyngeal Abrasive Therapy(EAT)는 만성 인두염에서 주요 전염증성 사이토카인 IL-6의 mRNA 발현을 감소시킵니다

Article

Published on 2022-08-162022-09-11
Journal: International Journal of Molecular Sciences [Category] 유전자 메커니즘,

Differences and similarities in endothelial and angiogenic profiles of preeclampsia and COVID-19 in pregnancy

임신 중 자간전증 및 COVID-19의 내피 및 혈관 신생 프로파일의 차이 및 유사성

Article

Published on 2022-08-012022-08-31
Journal: American journal of obstetrics and gynecology [Category] MERS, 바이오마커, 진단,

[키워드] absence activate addition Adhesion Molecule alteration Analysis Angiogenesis angiogenic factors angiopoietin Antigen Biomarker Biomarkers C5b9 Cell cell membrane cell membranes Cell signaling change changes in circulating Coagulation Coagulopathy component Concentration Control controls COVID-19 COVID-19 infection COVID-19 patients Culture demonstrated difference differential diagnosis differentiation disease disorder endothelial Endothelial cell endothelial cells endothelial damage Endothelial dysfunction evaluated exhibited expected explained expression Extracellular Extracellular matrix group growth growth factor healthy heparan sulfate hypertensive hypertensive disorders of pregnancy Immunoblots immunofluorescence in some in vitro increase in Infection Inflammation inflammatory signaling innate immune response intercellular intercellular adhesion molecule less lysate lysates Mild mitogen-activated protein kinase Necrosis neutrophil Neutrophil extracellular trap Neutrophil extracellular traps normotensive overexpression Pathways Patient Phosphorylation placental placental growth factor preeclampsia Pregnancy pregnant women Principal component principal component analysis profile profiles Protein protein kinase receptor reduced reduction reduction in SARS-CoV-2 sera severe COVID-19 severe COVID-19 patient signaling pathway significant increase significantly increased Signs and symptoms similarity soluble fms-like tyrosine kinase-1 soluble tumor necrosis factor-α receptor I Spectrum statistical analysis statistically Study design sulfate Symptom Tumor tumor necrosis tumor necrosis factor-α tyrosine variable variance vascular cell adhesion von Willebrand disease von Willebrand factor with COVID-19 women
[DOI] 10.1016/j.ajog.2022.03.048 PMC 바로가기 [Article Type] Article

Reveal the Mechanisms of Yi-Fei-Jian-Pi-Tang on Covid-19 through Network Pharmacology Approach

네트워크 약리학 접근법을 통해 Covid-19에 대한 Yi-Fei-Jian-Pi-Tang의 메커니즘 공개

Article

Published on 2022-07-162022-09-11
Journal: Computational Intelligence and Neuroscience [Category] 유전자 메커니즘,

[키워드] activated activator Adhesion Molecule AKT AKT1 Alpha Beta binding C-C motif chemokine ligand C-C motif chemokine ligand 2 cancers CASP8 caspase caspase 8 CCL2 chemokine Chinese contribute Corona Critical CXCL8 Cytoscape database demonstrated effective EGFR enhancer enrichment analysis epidermal epidermal growth factor ERBB2 Formula foundation Gene ontology genomes growth factor Herb HIF1a HMOX1 hypoxia ICAM1 IL10 IL1A IL1B IL2 IL4 IL6 ingredient inhibitor inquiry intercellular intercellular adhesion molecule interferon gamma interleukin interleukin 2 Interleukin 4 interleukin 6 JUN KEGG Kyoto Ligand MAPK3 MAPK8 mechanism Medicine mitogen-activated protein kinase MMP1 MMP3 motif MPO myeloperoxidase Necrosis network network pharmacology NFE2 NFE2L2 NFkB NFKBIA nitric oxide nitric oxide synthase NOS3 nuclear oncogene outcome p53 pathway Pathways Patient Pharmacology PPARA Protein protein kinase protein p53 protein-protein interaction receptor RELA Research Serine Stat1 STRING database subunit target target protein targets TCM TGFB1 therapeutic target threonine Timp1 TNF TP53 Traditional Traditional Chinese medicine Transcription transcription factor transforming growth factor Tumor tumor necrosis tumor necrosis factor tyrosine UniProt Virus Disease
[DOI] 10.1155/2022/1493137 PMC 바로가기 [Article Type] Article

Exploring the Immunomodulatory Aspect of Mesenchymal Stem Cells for Treatment of Severe Coronavirus Disease 19

중증 코로나바이러스 질환 치료를 위한 중간엽 줄기세포의 면역조절 측면 탐색 19

Review

Published on 2022-07-122022-09-11
Journal: Cells [Category] COVID19(2023년), SARS, 치료법,

[키워드] ACE-2 acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 acute respiratory syndrome coronavirus-2 administration affected Alpha alveolar epithelial cell alveolar epithelial cells angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 anti-apoptotic Anti-inflammatory anti-oxidative aspect Asymptomatic average Betacoronavirus breathlessness cause cellular characterized chemokines chest pain Clinical outcome Clinical symptoms colony-stimulating factor coronavirus 2 COVID-19 COVID-19 patient Critically ill critically ill COVID-19 patients curative cytokine Cytokine storm Cytokine storms damaged dependent on Deterioration disease severity dry cough Effectiveness Effects elicited endothelial engage enzyme epithelial cells excessive inflammation family Coronaviridae fatigue Fever fibroblast fibroblast growth factor functional GCSF genus genus Betacoronavirus granulocyte granulocyte colony-stimulating factor growth factor Growth factors Health healthy histological IL-6 IL-7 IL-8 IL-9 immune cells immune response immune responses immunomodulation immunomodulatory immunomodulatory capabilities immunomodulatory capability Incubation period individual infected individual infected individuals infiltrating immune cells Inflammatory Inflammatory cytokines inflammatory protein inhalation Injury Intention interferon interleukin intravenous intravenous infusion Invasion IP10 lung Lungs Macrophage majority MCP1 Mesenchymal stem cells MIP1A mitigate monocyte monocyte chemotactic protein-1 MSC MSCs multitude myriad Necrosis organ PDGFB persistence Platelet platelet-derived growth factor positioned positive Protein receptor reduce respiratory Respiratory droplets RNA SARS-CoV-2 SARS-COV-2 infection secretion Secretome Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 sore throat STEM stem cell stem cells subunit supportive therapy symptomatic therapeutic therapy tissue TNF-α translational transmitted Treatment Tumor tumor necrosis tumor necrosis factor tumor necrosis factor alpha undergo Vascular virus widespread
[DOI] 10.3390/cells11142175 PMC 바로가기 [Article Type] Review

Contribution of CD4+ T cell-mediated inflammation to diarrhea in patients with COVID-19

COVID-19 환자의 설사에 대한 CD4+ T 세포 매개 염증의 기여

Article

Published on 2022-07-012022-09-11
Journal: International Journal of Infectious Diseases [Category] Coronavirus, COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, 치료기술,

[키워드] ACE2 analyzed angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 association CD4/CD8 CD4+ CD4+ T cell CD4+ T cells Cell cells chemokine chemokines Colon contribute correlation analyses Correlation analysis COVID-19 CXCL10 CXCL11 CXCR3 determine diarrhea distribution expressed expression groups Gut identify Inflammation inflammation sites lymphocyte Lymphocyte subset Lymphocyte subsets mechanism Migration mRNA mRNA expression Necrosis no difference Patient patients with COVID-19 percentage percentages performed protease protein levels receptor SARS-CoV-2 SARS-COV-2 infection Serine serine 2 significant difference T cell T cells T-box TNFα transmembrane transmembrane protease serine 2 Tumor tumor necrosis tumor necrosis factor tumor necrosis factor-alpha
[DOI] 10.1016/j.ijid.2022.04.006 PMC 바로가기 [Article Type] Article

The polymorphism L412F in TLR3 inhibits autophagy and is a marker of severe COVID-19 in males

TLR3의 다형성 L412F는 자가포식을 억제하고 남성에서 심각한 COVID-19의 표지자입니다

Article

Published on 2022-07-012022-09-11
Journal: Autophagy [Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis association autoantigen autoimmune disorder Autoimmune disorders autophagosome autophagy autophagy pathways bafilomycin clinical trial clinical trials co-morbidity Cohort coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 patients demonstrated Diseases Frequency HEK293 cell HEK293 cells HLA HLA haplotype Hydroxychloroquine Impaired increases in Infectious diseases inhibit L412F male males marker mechanism morbidity Necrosis Plasmid poly(I:C) polymorphism provide Rapamycin rationale receiver operating characteristic receptor reduced respiratory risk severe acute respiratory syndrome Coronavirus severe COVID-19 severity shown statistically significant stimulated sub-cohort survival TLR3 TNFα transfected with treated Tumor tumor necrosis tumor necrosis factor
[DOI] 10.1080/15548627.2021.1995152 PMC 바로가기 [Article Type] Article

TNF-α + CD4 + T cells dominate the SARS-CoV-2 specific T cell response in COVID-19 outpatients and are associated with durable antibodies

TNF-α + CD4 + T 세포는 COVID-19 외래 환자에서 SARS-CoV-2 특이적 T 세포 반응을 지배하고 내구성 항체와 관련이 있습니다

Article

Published on 2022-06-212022-09-11
Journal: Cell Reports Medicine [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술,

[키워드] acute infection acute respiratory syndrome acute respiratory syndrome coronavirus Alpha antibodies antibody boost CD4 Cell Cohort coronavirus Coronavirus 2019 COVID-19 COVID-19 outpatient Cytokines enrolled feature IFNγ IL-21 Immunity Infection interferon gamma longitudinal maintenance mRNA mRNA vaccination NCT04331899 Necrosis Neutralizing antibodies neutralizing antibody percentage Post-infection predominant producing respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-neutralizing antibodies SARS-CoV-2-neutralizing antibody severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 T cell T cell response T cells Tfh the SARS-CoV-2 These data TNF-α Tumor tumor necrosis tumor necrosis factor tumor necrosis factor alpha
[DOI] 10.1016/j.xcrm.2022.100640 PMC 바로가기 [Article Type] Article

Plasma Markers of Neurologic Injury and Inflammation in People With Self-Reported Neurologic Postacute Sequelae of SARS-CoV-2 Infection

SARS-CoV-2 감염의 자가 보고된 신경학적 후급성 후유증이 있는 사람들의 신경학적 손상 및 염증의 혈장 표지자

Article

Published on 2022-06-142022-09-11
Journal: Neurology® neuroimmunology & neuroinflammation [Category] COVID19(2023년), MERS, SARS, 바이오마커,

[키워드] 95% CI absolute levels Acidic acute infection acute respiratory syndrome acute respiratory syndrome coronavirus biologic CNS Cohort coronavirus correlated correlation correlations defined demonstrated early recovery elevated Elevation elevations examined exhibited Fold change Fold changes GFAp greater identify immune activation immunologic marker individuals Infection Inflammation inflammatory pathway initial Injury interleukin interleukin 6 Intervention involved less light chain linear marker mechanism mixed-effects model monocyte monocyte chemoattractant protein 1 Necrosis neurologic not differ PASC Prevent primary clinical outcome Protein Recovery time reported respiratory SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Symptom Symptoms treat Tumor tumor necrosis tumor necrosis factor tumor necrosis factor α
[DOI] 10.1212/NXI.0000000000200003 PMC 바로가기 [Article Type] Article

Scutellarein Inhibits LPS-Induced Inflammation through NF-κB/MAPKs Signaling Pathway in RAW264.7 Cells

스쿠텔라레인은 RAW264.7 세포에서 NF-κB/MAPK 신호 전달 경로를 통해 LPS 유도 염증을 억제합니다

Article

Published on 2022-06-122022-09-11
Journal: Molecules [Category] 유전자 메커니즘,

[키워드] addition Anti-inflammatory can be used Cell cells Chinese composed Compound COVID-19 Cyclooxygenase cytokine Cytokines determine diploid endotoxin ERK expression Extracellular family Gram-negative bacteria Helicase IL-1β Immune cell immune cells immune system Inflammation Inflammatory inflammatory disorder inflammatory disorders inhibit interleukin interleukin-1β involved IκBα JNK kinases lipopolysaccharide LPS LPS-induced inflammation MAPK mechanism mitogen NF-kB NF-кB nitric oxide nitric oxide synthase no effect nuclear outer membrane p65 pathway Pathways pro-inflammatory mediators proinflammatory mediators protein kinase required SARS Coronavirus SCU scutellarein scutellarein (SCU). secretion shown stimulate stimulated TNF-α Topic treat Treatment Tumor tumor necrosis tumor necrosis factor tumor necrosis factor-α was reduced western blot
[DOI] 10.3390/molecules27123782 PMC 바로가기 [Article Type] Article

Famotidine activates the vagus nerve inflammatory reflex to attenuate cytokine storm

Famotidine은 미주 신경 염증 반사를 활성화하여 사이토카인 폭풍을 약화시킵니다.

Article

Published on 2022-05-162022-09-11
Journal: Molecular Medicine [Category] 유전자 메커니즘,

[키워드] Acetylcholine acetylcholine receptor activate Administered Alpha antagonist Anti-inflammatory anti-inflammatory activity anti-inflammatory effect Anti-inflammatory effects antiviral activity attenuate Blood brain barrier Brain cause Central nervous system characterized cholinergic Cholinergic anti-inflammatory pathway Cimetidine Clinical course Clinical studies clinical study Clinical use concentrations COVID-19 Cytokine storm disease dosage dosages Effect Evidence Famotidine Gastroesophageal reflux gastroesophageal reflux disease Genetic Histamine Histamine receptors ICV IL-6 Inflammatory inhibits inflammation knock-out lipopolysaccharide mast cell Mast cells mechanism mechanism of action mice morbidity and mortality Necrosis observation penetrate Prevent pro-inflammatory cytokine pro-inflammatory cytokine release Ranitidine recent receptor reduced released replicated serum severe COVID-19 Signal transduction Signaling significantly significantly more stimulated survival syndrome TNF treat Tumor tumor necrosis tumor necrosis factor vagus nerve Vagus nerve signaling. were assessed while α7nAChR
[DOI] 10.1186/s10020-022-00483-8 PMC 바로가기 [Article Type] Article