The effect of Nutrition Bio-shield superfood (NBS) on disease severity and laboratory biomarkers in patients with COVID-19: A randomized clinical trialArticle Published on 2022-11-012022-11-15 Journal: Microbial pathogenesis [Category] SARS, 바이오마커, [키워드] ALP assigned baseline body temperature can be used clinical clinical trial Clinical trial study control group COVID-19 COVID-19 disease COVID-19 disease severity CPK CRP determine dimer disease severity Effect effective ELISA kit ESR IL-6 immune system IMPROVE Intervention intervention group Iran laboratory biomarker laboratory biomarkers laboratory parameter LDH lymphocyte Lymphocyte count nutrition Nutrition bio-shield superfood. oxygen saturation Patient patients with COVID-19 performed Placebo Randomized randomized clinical trial receiving Result Serum level serum sample SGOT SGPT significant decrease significant increase single-blind Superfood Tehran tested the mean TNF-α Treatment Trial two group Two-arm variable was performed WBC [DOI] 10.1016/j.micpath.2022.105792 PMC 바로가기
Building Emotional Awareness and Mental Health (BEAM): study protocol for a phase III randomized controlled trial of the BEAM app-based program for mothers of children 18-36 monthsArticle Published on 2022-09-052022-10-05 Journal: Trials [Category] 임상, [키워드] Anxiety anxiety symptoms assessment Awareness build building children Cohort COVID-19 pandemic Depression Efficacy elevated emotion evaluate finding Follow-up Health IMPROVE improvement individual Intervention Maternal mental health mental health disorders mental illness mother occur pandemic Parenting pregnant Prevalence Primary outcome programming Psychoeducation Randomized Randomized controlled trial RCT RCT. recruited reducing repeated measure risk Secondary outcomes Stress Study protocol Support Symptom Symptoms symptoms of depression Tau treatment as usual treatment group Trial Two-arm used to evaluate [DOI] 10.1186/s13063-022-06512-5 PMC 바로가기 [Article Type] Article
Prospective two-arm study of the testicular function in patients with COVID-19COVID-19 환자의 고환 기능에 대한 전향적 양군 연구Clinical Trial Published on 2022-09-012022-09-11 Journal: Andrology [Category] COVID19(2023년), SARS, 임상, 치료기술, [키워드] Affect Agglutination reaction Analysis Autopsies Autopsy Cell Chest computed tomography collected Community Computed tomography Control COVID-19 COVID-19 pandemic COVID-19 patient damage died Direct discharge discharge home disorder Effect exhibited follicle-stimulating hormone Health Organization healthy control healthy controls Hospital stay human body increase in infiltration Inflammation International Laboratory lack Luteinizing Hormone majority male male fertility male hormone male reproductive system management MAR material moderate moderate to severe multiple organ multiple organs parameter participant Patient patients with COVID-19 patients with moderate positive postmortem examination Prospective Prospective Study reproductive reproductive system Research returned SARS-CoV-2 Semen Semen analysis severe disease significantly Sperm spermatogenesis Symptom testes testicle Testosterone the disease the healthy throat swab tissue Topic Trial Two-arm Viral pneumonia virus was performed WHO World Health Organization [DOI] 10.1111/andr.13159 PMC 바로가기 [Article Type] Clinical Trial
Prevention and early treatment of the long-term physical effects of COVID-19 in adults: design of a randomised controlled trial of resistance exercise-CISCO-21Randomized Controlled Trial Published on 2022-08-152022-10-05 Journal: Trials [Category] SARS, 임상, [키워드] Admission breathlessness cause chest pain Contact Controlled clinical trial COVID COVID-19 COVID-19 infection diagnosis of COVID-19 discharged Dyspnoea early treatment Effect Ethical approval ethics committee Exercise capacity fatigue frailty group Health Health status healthcare professionals hospital hospitalisation hospitalised Infection Intervention Long Long COVID National Health Service NHS participant Patient personalised physical physical activity Pragmatic prevention Primary outcome problem Quality of life questionnaire randomisation randomised randomised controlled trial REC recruitment Registered rehabilitation resistance resistance exercise SARS-CoV-2 secondary outcome spirometry Symptom syndrome therapy Two-arm usual care West [DOI] 10.1186/s13063-022-06632-y PMC 바로가기 [Article Type] Randomized Controlled Trial
Attractive targeted sugar bait phase III trials in Kenya, Mali, and Zambia케냐, 말리, 잠비아에서 매력적인 표적 설탕 미끼 3상 시험Clinical Trial Published on 2022-08-092022-09-11 Journal: Trials [Category] 말라리아, 임상, 치료제, [키워드] adaptive ARMS Attractive targeted sugar bait children Cluster cluster separation Cluster-randomized controlled trial Clusters Cohort Contamination Controlled trial core covariate covariates COVID-19 pandemic detect determine dinotefuran Effects External validity Follow-up Imbalance IMPROVE incidence include insecticidal insecticide interim analysis internal validity Intervention Kenya kill Longevity malaria morbidity mosquito density Open-label open-label design phase III trial Prevalence Primary outcome Primary outcomes randomization receive reduce reduction in reductions in Restricted resulting risk Sample size secondary outcome strength Structure sugar threat Transmission transmission pattern Trial Two-arm Validity Variation vector vector control vectors [DOI] 10.1186/s13063-022-06555-8 PMC 바로가기 [Article Type] Clinical Trial
Should RECOVERY have used response adaptive randomisation? Evidence from a simulation studyRandomized Controlled Trial Published on 2022-08-062022-10-04 Journal: BMC Medical Research Methodology [Category] SARS, 임상, [키워드] adaptive adaptive randomisation Adaptive trial Arm ARMS Care Community coronavirus COVID-19 COVID-19 mortality COVID-19 therapy defined Dexamethasone effective error rate estimate exhibiting FIVE fixed form hospitalised Hydroxychloroquine induce Lopinavir-ritonavir lower mortality Measures mortality rate other diseases Patient patient death patient subgroup performed Platform trial question randomisation randomised controlled trial Randomised Evaluation receiving recovery RECOVERY trial reduced reducing reduction REMAP-CAP representing Respiratory Support Response-adaptive randomization Simulation standard care Statistical power tested Treatment Trial Two-arm [DOI] 10.1186/s12874-022-01691-w PMC 바로가기 [Article Type] Randomized Controlled Trial
A pragmatic randomized trial of home-based testing for COVID-19 in rural Native American and Latino communities: Protocol for the “Protecting our Communities” studyArticle Published on 2022-08-012022-10-05 Journal: Contemporary clinical trials [Category] COVID19(2023년), SARS, 임상, 진단, [키워드] added American Arm ARMS benefit Care Community community health Community health worker Community trial conducted COVID-19 COVID-19 test COVID-19 testing economic barrier evaluate feasibility Health health worker Home-based testing implementation Implementing lab Laboratory Latino nasal swab Native Native American outcome participant Population populations Pragmatic Protecting Randomized Randomized controlled trial randomized trial receive reduce Research SARS-CoV-2 Support The United States Trial Two-arm Washington [DOI] 10.1016/j.cct.2022.106820 PMC 바로가기 [Article Type] Article
Effect of a 2-week interruption in methotrexate treatment versus continued treatment on COVID-19 booster vaccine immunity in adults with inflammatory conditions (VROOM study): a randomised, open label, superiority trialResearch article Published on 2022-06-272022-10-05 Journal: The Lancet. Respiratory Medicine [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 임상, 치료법, [키워드] 1:1 95% CI administration age Analysis Antibody Response Antibody titre Arthritis assigned atopic dermatitis booster Booster vaccine clinics COVID-19 COVID-19 vaccination COVID-19 vaccination programme COVID-19 vaccine data analyst Dermatology diagnosed domain dose Effect Efficacy evaluated female finding funding geometric geometric mean ratio GMR groups hospital Immune-mediated Immune-mediated inflammatory disease Immune-mediated inflammatory diseases Immunity inflammatory condition inflammatory disease inhibit intention-to-treat population interim analysis Intervention investigators Laboratory low-dose methotrexate mixed-effects model multicentre open label Open-label parallel-group participant Participants Patient platform Primary outcome randomisation randomised Randomly receiving recruited recruitment Registered Research researcher rheumatoid arthritis rheumatology SARS-CoV-2 SARS-COV-2 infection Serious Adverse Events Spike protein spondyloarthritis susceptible systemic lupus erythematosus the SARS-CoV-2 translate Treatment treatment as usual Trial Two-arm vaccination Vaccine vaccine dose Vaccine-induced immunity [DOI] 10.1016/S2213-2600(22)00186-2 [Article Type] Research article
cfDNA as a surrogate marker for COVID-19 severity in patients with influenza-like symptoms with and without SARS-CoV-2 infections in general practice: a study protocol for a prospective cohort study일반적으로 SARS-CoV-2 감염이 있거나 없는 인플루엔자 유사 증상이 있는 환자에서 COVID-19 중증도에 대한 대리 표지자로서의 cfDNA: 전향적 코호트 연구를 위한 연구 프로토콜Article Published on 2022-06-162022-09-11 Journal: BMJ Open [Category] COVID19(2023년), MERS, SARS, 바이오마커, [키워드] (cfDNA ambulatory patient ambulatory patients Blood blood count Blood samples C-reactive protein C-reactive protein (CRP Cell Cell Biology cell-free DNA cfDNA Clinical course clinical parameter Clinical parameters Concentration concomitant symptoms correlation Course COVID-19 COVID-19 severity CRP death determine differential blood count differentiation erythrocyte sedimentation erythrocyte sedimentation rate Essen Ethical approval Ethics ethics committee examination finding flu-like symptom flu-like symptoms general medicine (see internal medicine) General practice identify Infection Influenza influenza-like symptom Influenza-like symptoms internal medicine International Laboratory lead longitudinal cohort study lung Lungs lymphocyte Lymphocyte count lymphocyte counts marker Molecular biology National oxygen oxygen saturation parameters Patient patients peer-reviewed Physicians Predictive Prognosis prospective cohort study questionnaire recruited registration number reported SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 patient SARS-CoV-2 patients sedimentation rate Study protocol Symptom temperature the disease Two-arm [DOI] 10.1136/bmjopen-2021-058647 PMC 바로가기 [Article Type] Article
Randomised controlled trial of a behaviour change physiotherapy intervention to increase physical activity following hip and knee replacement: the PEP-TALK trialRandomized Controlled Trial Published on 2022-05-312022-10-05 Journal: BMJ Open [Category] 임상, [키워드] 1:1 95% CI activity adult orthopaedics adverse event age allocation Blinding Care cognitive Comorbidities Compliance contributed Controlled trial COVID-19 pandemic Effectiveness eligibility English Evidence hip hospital hospitals inactive individual Intervention knee Los Angele National Health Service nine no difference outcome Pain participant physical activity Physical inactivity Pragmatic proportion Psychological distress Quality of life randomised randomised controlled receive reduced rehabilitation rheumatology Sample size score secondary outcome Self-efficacy Trial Two-arm University of California usual care women [DOI] 10.1136/bmjopen-2022-061373 PMC 바로가기 [Article Type] Randomized Controlled Trial