Evaluation of IFNAR2 and TYK2 transcripts’ prognostic role in COVID-19 patients: a retrospective studyarticle Published on 2024-04-292024-09-05 Journal: Frontiers in Cellular and Infection Microbiology [Category] update2024, [키워드] Coronavirus disease 2019 interferon alpha-beta receptor IFNAR2 subunit Prognostic factor SARS coronavirus 2 tyrosine kinase [DOI] 10.3389/fcimb.2024.1356542 PMC 바로가기 [Article Type] article
From Genes to Therapy: Pituitary Adenomas in the Era of Precision MedicineReview Published on 2023-12-212024-09-05 Journal: Biomedicines [Category] update2024, [키워드] Biomarkers cancer progression epigenetics Genetic stability hormone hypersecretion Immunotherapy molecular mechanisms mTOR inhibitors pituitary adenomas radiological imaging Targeted therapies transcriptomics tumor microenvironment tyrosine kinase VEGF inhibitors [DOI] 10.3390/biomedicines12010023 PMC 바로가기 [Article Type] Review
Amuvatinib Blocks SARS-CoV-2 Infection at the Entry Step of the Viral Life Cyclearticle Published on 2023-03-302024-09-05 Journal: Microbiology Spectrum [Category] update2024, [키워드] amuvatinib COVID-19 SARS-CoV-2 therapeutic agent tyrosine kinase [DOI] 10.1128/spectrum.05105-22 PMC 바로가기 [Article Type] article
Imatinib (STI571) Inhibits the Expression of Angiotensin-Converting Enzyme 2 and Cell Entry of the SARS-CoV-2-Derived Pseudotyped Viral ParticlesArticle Published on 2021-06-282022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS, [키워드] ACE2 ACE2 gene angiotensin-converting enzyme 2 approved Cancer Care Cell Cell culture cell entry clinically combined treatment COVID-19 COVID-19 infection Effect expression Imatinib Imatinib (STI571 inhibit inhibitor intestine kinase lung mice other organ Particle protein levels pseudoparticle receptor renal SARS-CoV-2 screened STI571 surface receptor therapeutic therapeutic target tissue expression transcript tyrosine tyrosine kinase tyrosine kinase inhibitor was reduced [DOI] 10.3390/ijms22136938 PMC 바로가기 [Article Type] Article
The Interference between SARS-CoV-2 and Tyrosine Kinase Receptor Signaling in Cancer암에서 SARS-CoV-2와 티로신 키나제 수용체 신호 전달 간의 간섭Review Published on 2021-05-022022-09-10 Journal: International Journal of Molecular Sciences [Category] SARS, 신약개발, 유전자 메커니즘, 치료제, [키워드] accelerate activated addition approach Cancer cancer cell Cancer cells cell proliferation Characteristics clinically coronavirus correlation COVID-19 Critical diagnosed division downstream downstream signaling pathways drug Drug repurposing dysregulation dysregulations EGFR help identify infection rate information interact interfere Interference Invasion kinase management mechanism MERS metabolism pandemic pathogen Pathways Patient phenotypic produced receptor repurposing required Research research and development resource SARS-CoV-1 SARS-CoV-1 and -2 SARS-CoV-2 Scientific community signaling pathway signaling pathways strongly related Structure therapeutic agent therapeutic agents Therapeutic compounds treat Treatment tyrosine tyrosine kinase tyrosine kinase receptor Viral viral infection Viral vector virus viruses [DOI] 10.3390/ijms22094830 PMC 바로가기 [Article Type] Review
SOCS, Intrinsic Virulence Factors, and Treatment of COVID-19SOCS, 내재 독성 인자 및 COVID-19의 치료Review Published on 2020-10-232022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, [키워드] Activation acute respiratory syndrome antagonist antiviral peptide block caused Cell coronavirus COVID-19 COVID-19 pandemic cytokine signaling death Defense effective embryonic Factor Factors herpes simplex herpes simplex virus Herpes Simplex Virus 1 Host HSV-1 IFN IFNγ induce infections inflammatory disease Influenza influenza A influenza A virus inhibit inhibitor inhibitors inhibitory inhibitory activity interferon interferon gamma intrinsic JAK2 kinase kinases KIR leads mechanism mice Neonatal neonatal death Other palmitate pathogenic pathogenic virus penetration peptide phosphorylated Prevent Prophylactic required respiratory SARS-CoV-2 SARS-CoV2 Severe acute respiratory syndrome shown SOCS1 SOCS3 Spike protein STAT STATs suppressor therapeutic transcription factor TYK2 type I tyrosine tyrosine kinase vaccinia virus Viral Viral virulence virulence virulence factors virus virus pathogenesis viruses [DOI] 10.3389/fimmu.2020.582102 PMC 바로가기 [Article Type] Review
The role of growth factor receptors in viral infections: An opportunity for drug repurposing against emerging viral diseases such as COVID‐19?Hypothesis Published on 2020-04-112022-11-01 Journal: FASEB BioAdvances [Category] COVID-19, [키워드] Cancer cancer drugs Cell coronavirus disease COVID‐19 COVID‐19 drug effective therapy growth factor Growth factors heparan sulfate heparin in viral inhibitors involved physically receptor replicate SARS‐CoV‐2 Signaling tyrosine tyrosine kinase viral disease viral infection viral infections virus [DOI] 10.1096/fba.2020-00015 PMC 바로가기 [Article Type] Hypothesis
CD95/Fas, Non-Apoptotic Signaling Pathways, and KinasesReview Published on 2017-09-272023-08-30 Journal: Frontiers in Immunology [Category] E형 간염, [키워드] Apoptosis Endothelium FAS FASL lupus metastasis Migration tyrosine kinase [DOI] 10.3389/fimmu.2017.01216 PMC 바로가기 [Article Type] Review