Thapsigargin and Tunicamycin Block SARS-CoV-2 Entry into Host Cells via Differential Modulation of Unfolded Protein Response (UPR), AKT Signaling, and ApoptosisArticle Published on 2024-04-302024-09-05 Journal: Cells [Category] update2024, [키워드] Apoptosis ER stress immune response insulin resistance lipid droplets Lipoproteins SARS-CoV-2 thapsigargin Tunicamycin unfolded protein response [DOI] 10.3390/cells13090769 PMC 바로가기 [Article Type] Article
Emerging evidence for poxvirus-mediated unfolded protein response: Lumpy skin disease virus maintains self-replication by activating PERK and IRE1 signalingArticle Published on 2023-05-012023-06-10 Journal: FASEB journal : official publication of the Federa [Category] 원숭이두창, [키워드] Cell signaling endoplasmic reticulum stress lumpy skin disease virus poxvirus unfolded protein response [DOI] 10.1096/fj.202300028R
Glucose and mannose analogs inhibit KSHV replication by blocking N-glycosylation and inducing the unfolded protein responseArticle Published on 2023-01-012023-06-20 Journal: Journal of medical virology [Category] Fulltext, MERS, [키워드] 2-deoxy-2-fluoro-d-mannose 2-deoxy-D-glucose 2-fluoro-deoxy-d-glucose Kaposi's sarcoma herpesvirus sugar analogs unfolded protein response [DOI] 10.1002/jmv.28314 PMC 바로가기
SARS-CoV-2 Diverges from Other Betacoronaviruses in Only Partially Activating the IRE1α/XBP1 Endoplasmic Reticulum Stress Pathway in Human Lung-Derived CellsArticle Published on 2022-10-262022-11-15 Journal: mBio [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, 치료기술, [키워드] activate Activation activities activity acute respiratory syndrome betacoronaviruses Cell cellular change coronavirus country Critical death downstream Endoplasmic reticulum enzyme ER stress examined expression of gene functions Gene Expression HCoV-OC43 Host host cell host cells host immune system Human human cell human cells imperative individual induce infect Infection inhibit interact IRE1α pathway less limit MERS-CoV MHV Middle East molecular mechanism mRNA murine OC43 Other other coronavirus pathway Prevent processed Replication required Respiratory Coronavirus respiratory syndrome coronavirus Reticulum RNase SARS-CoV SARS-CoV-2 SARS-COV-2 infection severe respiratory disease signaling pathway similarity splice Spread Stress tested the interferon transcription factor Trigger unfolded protein response UPR Vaccine viral replication virus XBP1 [DOI] 10.1128/mbio.02415-22 PMC 바로가기
Endoplasmic reticulum secretory pathway: Potential target against SARS-CoV-2Article Published on 2022-10-152022-11-15 Journal: Virus research [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] accelerate acute respiratory syndrome approach approved benefit caused cell membrane Clinical use coronavirus Coronavirus disease 2019 COVID-19 death demonstrated dependent on drug effort Endoplasmic reticulum ERS pathway Extensive feasibility globe inhibitor New overcome pathway pharmacological Potential Protein protein translation regulatory agencies Replication resulting SARS-CoV-2 SARS-COV-2 infection secretory pathway shown suppress targeting the SARS-CoV-2 therapeutic option unfolded protein response virion [DOI] 10.1016/j.virusres.2022.198897 PMC 바로가기
Impact of SARS-CoV-2 RBD Mutations on the Production of a Recombinant RBD Fusion Protein in Mammalian CellsArticle Published on 2022-08-242022-11-16 Journal: Biomolecules [Category] SARS, 변종, [키워드] accumulation assist B.1.351 B.1.351 variant cells chaperone chaperones contribute correlated COVID-19 diagnostic diagnostics disulphide bond domain E484K E484K mutation effort Endoplasmic reticulum expressed fusion Impact interfere mammalian mammalian cells misfolding mutant Mutation PDIA2 producing Production Protein protein disulphide isomerase protein yield. protocols RBD RBD mutation RBD protein RBD-Fc fusion protein recombinant recombinant RBD protein reduced resulting SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 variant secretion the RBD unfolded protein response UPR upregulation Vaccine variants [DOI] 10.3390/biom12091170 PMC 바로가기
SARS-CoV-2 ORF8 reshapes the ER through forming mixed disulfides with ER oxidoreductasesArticle Published on 2022-08-012023-07-09 Journal: Redox Biology [Category] COVID19(2023년), [키워드] Endoplasmic reticulum ORF8 redox SARS-CoV-2 unfolded protein response [DOI] 10.1016/j.redox.2022.102388 PMC 바로가기
Repurposing the Antiplatelet Agent Ticlopidine to Counteract the Acute Phase of ER Stress Condition: An Opportunity for Fighting Coronavirus Infections and Cancer응급실 스트레스 상태의 급성기에 대응하기 위해 항혈소판제 티클로피딘의 용도 변경: 코로나바이러스 감염 및 암 퇴치를 위한 기회Article Published on 2022-07-062022-09-11 Journal: Molecules [Category] COVID19(2023년), SARS, 신약개발, [키워드] Achille agent antiplatelet Antiplatelet agent approach approved drugs attribute Cancer Cancer cells Cell Coronavirus infections Coronavirus-2 COVID-19 demonstrated Endoplasmic reticulum endoplasmic reticulum (ER) ER membranes ER stress exacerbating Fighting heel homeostasis life cycle Metastasis Modification modulation opportunity P2Y12 P2Y12 inhibitors pathological conditions Perturbation phase promote receptor representing repurposing responsible SARS Coronavirus SARS-CoV-2 sigma sigma 1 receptor (S1R) terminal UPR the disease therapeutic intervention Therapies ticlopidine ticlopidine. Tumor tumor growth unfolded protein response UPR viral glycoprotein viral glycoproteins viral infection viral infections viral life cycle [DOI] 10.3390/molecules27144327 PMC 바로가기 [Article Type] Article
Molecular signature of postmortem lung tissue from COVID-19 patients suggests distinct trajectories driving mortalityCOVID-19 환자의 사후 폐 조직의 분자 서명은 사망률을 이끄는 뚜렷한 궤적을 시사합니다Article Published on 2022-05-012022-09-12 Journal: Disease Models & Mechanisms [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] absence Activation acute respiratory syndrome Autopsy can be used CCL19 characteristic classical complement controls coronavirus COVID-19 COVID-19 patient CRS cytokine cytokine release dominant driving in silico infections Infectious disease lung lung abnormality lung damage Lung microbiome Lung pathology lung tissue majority Metatranscriptomics Microbiome molecular molecular mechanism Mortality Pasteurella pathogen Patient patients performed SARS-CoV-2 SARS-COV-2 infection secondary infections Sequencing severe COVID-19 severe COVID-19 patients Staphylococcus suffered supported syndrome therapy trajectory unfolded protein response uninfected upregulation Whole-transcriptome sequencing. [DOI] 10.1242/dmm.049572 PMC 바로가기 [Article Type] Article
TRMT6/61A-dependent base methylation of tRNA-derived fragments regulates gene-silencing activity and the unfolded protein response in bladder cancer Research Published on 2022-04-202022-10-05 Journal: Nature Communications [Category] 변종, 유전자 메커니즘, [키워드] Affect bladder Bladder cancer cellular correlated dataset dysregulation functions Gene Expression gene silencing group involved mapped mechanism Messenger RNA Methylation Modification N1-methyladenosine over-expressed regulate regulatory element RNA RNA modification RNAs Small RNAs target transfer unfolded protein response [DOI] 10.1038/s41467-022-29790-8 [Article Type] Research