Severity of SARS-CoV-2 Omicron BA.2 infection in unvaccinated hospitalized children: comparison to influenza and parainfluenza infections예방접종을 받지 않은 입원 소아에서 SARS-CoV-2 Omicron BA.2 감염의 심각도: 인플루엔자 및 파라인플루엔자 감염과의 비교Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, [키워드] 95%CI acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adjusted Admission children Clinical outcome coronavirus COVID-19 COVID-19 infection Croup database death had no hospitalisation hospitalisations Hospitalization Hospitalized Infection Influenza Influenza virus initial investigated Mild neurological Neurological complication Neurological complications occurred omicron outcome parainfluenza parainfluenza virus proportion Public Hospital Relative risk required respiratory retrieved risk SARS-CoV-2 severe acute respiratory syndrome Coronavirus severity uninfected upper airway upper airways vaccination variant viral infections virus viruses were recorded [DOI] 10.1080/22221751.2022.2093135 PMC 바로가기 [Article Type] Article
Omicron BA.2.75 variant is efficiently neutralised following BA.1 and BA.5 breakthrough infection in vaccinated individuals, Israel, June to September 2022Article Published on 2022-11-012022-11-15 Journal: Eurosurveillance [Category] SARS, 변종, 진단, [키워드] Breakthrough infection dose evaluated HCW healthcare worker Infection infections neutralising neutralising antibody neutralising antibody titre omicron Omicron variants, neutralising antibodies SARS-CoV-2 uninfected vaccinated individual vaccinated individuals Vaccine variant variants wild type [DOI] 10.2807/1560-7917.ES.2022.27.44.2200785 PMC 바로가기
Sensitive Serology Measurements in the Saliva of Individuals with COVID-19 Symptoms Using a Multiplexed ImmunoassayArticle Published on 2022-10-292022-11-15 Journal: The journal of applied laboratory medicine [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] acute respiratory syndrome Antigen benefit causative pathogen collected controls coronavirus coronavirus disease COVID-19 cut-off detect Diagnosis domain group IgG individual individuals with COVID-19 infected individual infected individuals levels of antibody measurement multiplex serology multiplexed immunoassay N-terminal domain nucleocapsid nucleocapsid protein PSO Receptor-binding domain ROC ROC AUC Saliva salivary SARS-CoV-2 sensitive sensitivity Seroconversion serology specificity subjects uninfected uninfected control with COVID-19 [DOI] 10.1093/jalm/jfac073 PMC 바로가기
Analysis of anti-SARS-CoV-2 Omicron-neutralizing antibody titers in different vaccinated and unvaccinated convalescent plasma sourcesArticle Published on 2022-10-292022-11-15 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] anti-SARS-CoV-2 Antibody titer CCP collected convalescent plasma COVID-19 Donor dose effective geometric geometric mean titer Immune escape Immunocompromised implication Infection lesson monoclonal antibodies monoclonal antibody mRNA vaccine neutralization neutralize Neutralizing Neutralizing antibody titer omicron Outpatient pandemic plasma plasma activity provide recipients reduction representing SARS-CoV-2 variant sera subject therapeutic Therapies uninfected vaccinee variant variants of concern [DOI] 10.1038/s41467-022-33864-y PMC 바로가기
BNT162b2-induced neutralizing and non-neutralizing antibody functions against SARS-CoV-2 diminish with ageArticle Published on 2022-10-252022-11-15 Journal: Cell Reports [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome addition age antibody Antibody glycosylation BNT162b2 mRNA vaccine breadth coronavirus COVID-19 CP: Immunology disease domain dose Efficacy Fab Fc effector functions Fc function Fc receptor FIVE function functions greater immune cells Immunity individual induce Infection isolate magnitude neutralization neutralize Neutralizing Neutralizing activity non-neutralizing antibody omicron polyclonal antibody populations promote provide response SARS-CoV-2 SARS-CoV-2 variants sera uninfected Vaccine vaccine-specific antibodies variant variants virus wild-type [DOI] 10.1016/j.celrep.2022.111544 PMC 바로가기
Evidence for the spread of SARS-CoV-2 and olfactory cell lineage impairment in close-contact infection Syrian hamster modelsArticle Published on 2022-10-212022-11-15 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), SARS, 치료기술, [키워드] addition Administered assigned caused Cell cells changes in close contact complication of COVID-19 Contact days post infection detectable examined group groups hamster highest immature Impact impairment indicated Infection Lineage lung lung damage lung; nose occurred olfactory Olfactory epithelium olfactory receptor cells ORN ORNs pathogenesis of COVID-19 patients with COVID-19 receptor SARS-CoV-2 short-term cohabitation. significantly Spread subsequent tissue tissue damage transmitted uninfected unique Viral load viral presence Viral transmission virus [DOI] 10.3389/fcimb.2022.1019723 PMC 바로가기
Cellular interferon-gamma and interleukin-2 responses to SARS-CoV-2 structural proteins are broader and higher in those vaccinated after SARS-CoV-2 infection compared to vaccinees without prior SARS-CoV-2 infectionArticle Published on 2022-10-172022-11-15 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 진단, [키워드] assays BNT162b2 BNT162b2 vaccine class correlated demonstrated develop dose doses epitope exhibited Frequency greater healthcare worker healthy IFN-γ IgG response IL-2 IL2 Immunity individual infected with SARS-CoV-2 Infection Interferon-gamma interleukin-2 magnitude Moderna mRNA-1273 vaccine mononuclear cell mRNA-1273 N and M nine participant Participants PCR testing peptide Peripheral blood Pfizer-BioNTech positive Post-infection Proteins proteome repeated responders response responses against robust S glycoprotein S1 and S2 S2 subunit SARS-CoV-2 SARS-COV-2 infection structural protein subunit subunits T cell response T-cell Response the SARS-CoV-2 uninfected vaccination vaccinee was determined were expressed with COVID-19 [DOI] 10.1371/journal.pone.0276241 PMC 바로가기
Comparison of the kinetics and magnitude of antibody responses to different SARS-CoV-2 proteins in Sinopharm/BBIBP-CorV vaccinees following the BNT162b2 booster or natural infectionArticle Published on 2022-10-132022-11-15 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 진단, [키워드] ACE2 anti-RBD antibodies antibody Antibody Response BNT162b2 booster Cohort dose Frequency highest IgG antibody immune response implication individual infected individual Infection investigated lowest magnitude natural infection persistence post vaccination Protein receive remained robust S1 and S2 SARS-CoV-2 protein second dose significantly higher Sinopharm subsequent the N protein the RBD the SARS-CoV-2 virus total antibody uninfected vaccinee vaccinees were infected [DOI] 10.1371/journal.pone.0274845 PMC 바로가기
Humoral and cellular immune response over 9 months of mRNA-1273, BNT162b2 and ChAdOx1 vaccination in a University Hospital in SpainArticle Published on 2022-10-072022-11-15 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 진단, [키워드] antibody BNT162b2 booster vaccinations carried cellular Cellular immune response cellular immunity ChAdOx1 COVID-19 COVID-19 vaccination dose elimination half-life Follow-up healthcare worker Heterologous humoral Immunity individual infected individual inoculated mRNA-1273 naïve Naturally participant preserved Prospective Study receiving reported robust SARS-CoV-2 spike second dose single dose Spain T cell uninfected university vaccination Vaccine Validity [DOI] 10.1038/s41598-022-19537-2 PMC 바로가기
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Outbreak at a College With High Coronavirus Disease 2019 (COVID-19) Vaccination Coverage-Connecticut, August 2021-September 2021Article Published on 2022-10-032022-11-16 Journal: Clinical Infectious Diseases: An Official Publicat [Category] COVID19(2023년), SARS, 변종, [키워드] 95% CI 95% confidence interval activity acute respiratory syndrome adjusted odds ratio Analysis attack Attending Characteristics collected college Community Complete Connecticut coronavirus coronavirus 2 Coverage COVID-19 Delta delta variant demographics Department diagnosed Enrollment genomes higher education highest Infection information investigated laboratory-confirmed Logistic regression multivariate outbreak Phylogenetic relationship provided Public reduce respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 transmission student suggested uninfected vaccination Vaccine Vaccine breakthrough viral genome sequence [DOI] 10.1093/cid/ciac422 PMC 바로가기