Breakthrough SARS-CoV-2 infections after vaccination: a critical review백신 접종 후 획기적인 SARS-CoV-2 감염: 비판적 검토Review Published on 2022-11-302022-09-12 Journal: Human vaccines & immunotherapeutics [Category] MERS, SARS, 진단, [키워드] acute respiratory syndrome antibody assumption breakthrough coronavirus COVID-19 COVID-19 infection Critical Evidence Humoral immunity Immunity immunization individual induce infected patients Infection pandemic raised Reinfection SARS-CoV-2 SARS-COV-2 infection unlikely vaccination [DOI] 10.1080/21645515.2022.2051412 PMC 바로가기 [Article Type] Review
Perceived feasibility, facilitators and barriers to incorporating point-of-care testing for SARS-CoV-2 into emergency medical services by ambulance service staff: a survey-based approachArticle Published on 2022-11-032022-11-15 Journal: BMJ Open [Category] SARS, 진단, [키워드] Accuracy acquisition ambulance service Analysis approach assessments assistant Care Characteristics clinical decision clinical utility collected COVID-19 criteria current elicit Emergency emergency situation facilitator feasibility feasible Follow-up healthcare services indicated Lateral flow device majority medical service molecular diagnostics Perceived point-of-care qualitative data qualitative research rapid SARS-CoV-2 testing required response risk stratification SARS-CoV-2 SARS-CoV-2 test Sensitivity and specificity supported survey to define unlikely while [DOI] 10.1136/bmjopen-2022-064038 PMC 바로가기
Naturally occurring spike mutations influence the infectivity and immunogenicity of SARS-CoV-2Article Published on 2022-11-012022-11-15 Journal: Cellular and Molecular Immunology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] A570D A701V addition Affect affected antibodies antigenicity B.1.1.529 B.1.1.7 B.1.1.7 lineage B.1.351 B.1.617.2 BALB/c mice binding circulating cross-neutralization activity D1118H decrease Del Delta determine DNA vaccine Effects Efficiency elicited humoral immune response immune evasion immunized immunogen in vitro investigated K417N L18F Lineage Mutation NAbs Naturally neutralization Neutralizing Neutralizing antibodies neutralizing antibody NTD omicron opposite overcome P681H Pseudotyped viruses reduced S982A SARS-CoV-2 SARS-CoV-2 variant sera significantly increased single mutation single mutations spike mutation T cell T cell responses T-cell Response T716I tested the RBD Transmissibility unlikely Vaccine vaccine immunogenicity variants of concern viral entry viral infectivity VoC VOCs was determined weakened [DOI] 10.1038/s41423-022-00924-8 PMC 바로가기
Low Risk of Severe Acute Respiratory Syndrome Coronavirus 2 Transmission by Fomites: A Clinical Observational Study in Highly Infectious Coronavirus Disease 2019 PatientsArticle Published on 2022-11-012022-11-15 Journal: The Journal of Infectious Diseases [Category] SARS, 치료기술, [키워드] acute respiratory syndrome addressed baseline carrier Cell culture clinical coronavirus 2 coronavirus disease Coronavirus-2 coughing COVID-19 COVID-19 patient Culture Cycle threshold value evaluate fomite transmission Hospitalized Infectious virus initiated Intensive laboratory parameter occur oropharyngeal swab pandemic Patient polymerase chain positive Quantitative respiratory risk Saliva SARS-CoV-2 SARS-CoV-2 transmission Sequencing single-center stability surface stability Swab Transmission unlikely Viral load viral ribonucleic acid virus virus transmission [DOI] 10.1093/infdis/jiac170 PMC 바로가기
An experimental test of the nicotinic hypothesis of COVID-19Article Published on 2022-11-012022-11-16 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acetylcholine receptors acute respiratory syndrome binding binding competition assays cells competing complex coronavirus COVID-19 disease ectodomain effort expressed Hypothesis Infection Ligand nicotinic receptors pathophysiological mechanism peptides performed Rabies virus receptor receptors S1 domain SARS-CoV-2 SARS-CoV-2 spike protein Spike protein suggested Symptom tested the SARS-CoV-2 unlikely virus [DOI] 10.1073/pnas.2204242119 PMC 바로가기
Immunogenicity, Safety, and Anti-Viral Efficacy of a Subunit SARS-CoV-2 Vaccine Candidate in Captive Black-Footed Ferrets ( Mustela nigripes) and Their Susceptibility to Viral ChallengeArticle Published on 2022-10-042022-11-15 Journal: Viruses [Category] COVID19(2023년), SARS, 진단, 치료제, [키워드] Affect Anti-viral Antibody Response Antibody titer black-footed ferrets candidate challenge clinical disease correlated declined Efficacy experimental challenge ferret highest Human immunogenicity in vitro in vivo increase in indicate lack lung viral load mice morbidity Mortality mustelids pathogen populations potential risk pre-vaccination produced Protein purified Safety SARS-CoV-2 SARS-CoV-2 S1 serum subunit susceptibility transfer Trial unlikely upper respiratory tract vaccination vaccinees viral replication was determined [DOI] 10.3390/v14102188 PMC 바로가기
Risk of vertical transmission of SARS CoV-2 infection to neonates born to covid positive mothers: A pilot study from a tertiary care hospital of North India코로나 바이러스 양성 산모에게서 태어난 신생아에게 SARS CoV-2 감염의 수직 전파 위험: 북인도의 3차 병원에서 실시한 파일럿 연구Article Published on 2022-10-012022-09-11 Journal: Journal of infection and chemotherapy : official j [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] amniotic Amniotic fluid Analysis anti-SARS-CoV-2 IgG anti-SARS-CoV-2 IgG antibodies anti-SARS-CoV-2 IgG antibody anti-SARS-CoV-2 IgM antibody biological sample Blood Breast breast milk Care Cervicovaginal secretion clinical implication conducted Cord blood Cord blood IgG-IGM COVID-19 demonstrated disease disease severity fetal fetal membrane greater hospital IgG IgM antibodies Immunoglobulin India Infection material mechanism membrane mother Nasopharyngeal swab Neonatal Neonate Neonates North passive immunity performed pilot study positive positive correlation pregnant women Presence Prospective Study risk RT-PCR SARS CoV-2 SARS-CoV-2 SARS-COV-2 infection secretion shown tested Transmission unlikely vertical transmission virus women [DOI] 10.1016/j.jiac.2022.06.004 PMC 바로가기 [Article Type] Article
Increases in symptoms of depression and anxiety in adults during the initial phases of the COVID-19 pandemic are limited to those with less resources: Results from the Lifelines Cohort StudyResearch article Published on 2022-10-012022-10-05 Journal: Journal of psychiatric research [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, [키워드] age agency And personality Anxiety anxiety symptoms association average baseline Capital class condition COVID COVID-19 COVID-19 cohort COVID-19 pandemic Depression element ENhance finding Health health condition increase increase in individual individuals initial Latent less maintain mental health MOST number of symptom obesity Odds ratio predicted Probability ranged receive reported reporting symptom Research resource Result socioeconomic status subsequent Symptom symptoms of depression the mean trajectory unlikely were used [DOI] 10.1016/j.jpsychires.2022.07.011 [Article Type] Research article
Plasma SARS-CoV-2 nucleocapsid antigen levels are associated with progression to severe disease in hospitalized COVID-19Article Published on 2022-09-142022-11-15 Journal: Critical Care [Category] SARS, 치료기술, [키워드] 95% CI adjusted Antigen association AUROC baseline Clinical deterioration Clinical outcome clinical outcomes clinical status Coagulation collected Concentration correlated correlation correlations Course COVID-19 Cutoff death detectable Enrollment Hospital admission hospitalized COVID-19 hospitalized patient host response ICU admission IL-10 IMPROVE In-hospital increase in Inflammation IP-10 marker mechanical ventilation Multiple multiple logistic regression N-antigen Negative predictive value Pathogenesis Patient plasma plasma biomarker plasma concentration plasma sample Positive predictive value Primary outcome Prognosis prognostic progression prospective observational cohort RAGE risk stratification SARS-CoV-2 SARS-CoV-2 N-antigen SARS-CoV-2 nucleocapsid secondary outcome severe disease significantly Study participants subject tested tissue damage unlikely upper respiratory tract Viral antigen Viral RNA was used were assessed were measured WHO WHO ordinal scale with COVID-19 World Health Organization [DOI] 10.1186/s13054-022-04153-3 PMC 바로가기
Detection of Higher Cycle Threshold Values in Culturable SARS-CoV-2 Omicron BA.1 Sublineage Compared with Pre-Omicron Variant Specimens – San Francisco Bay Area, California, July 2021-March 2022Article Published on 2022-09-092022-11-15 Journal: Morbidity and Mortality Weekly Report [Category] SARS, 변종, 치료기술, [키워드] Analysis Area B.1.1.529 cause CDC Cohort collected COVID-19 Culture cycle cycle threshold demonstrated detection generate Guidance in viral Infection infections Infectious virus marker nasal omicron participant positive public health reliability remains uncertain Research RNA RT-PCR San Francisco Bay SARS-CoV-2 SARS-CoV-2 test SARS-CoV-2 variant SARS-CoV-2 variants specimen Supporting These data unlikely value variant variant of SARS-CoV-2 Viral RNA virus were used [DOI] 10.15585/mmwr.mm7136a3 PMC 바로가기