A Real-World Retrospective Analysis of the Management of Advanced Urothelial Carcinoma in CanadaArticle Published on 2024-01-252024-09-05 Journal: Current Oncology [Category] update2024, [키워드] Avelumab carboplatin care gap Chart review cisplatin Immunotherapy maintenance therapy platinum-based chemotherapy unmet need urothelial carcinoma [DOI] 10.3390/curroncol31020052 PMC 바로가기 [Article Type] Article
COVAD survey 2 long-term outcomes: unmet need and protocolArticle Published on 2022-12-012022-11-15 Journal: Rheumatology International [Category] 치료제, [키워드] adverse event antiviral drug approach approved Autoimmune diseases baseline booster doses cohorts COVID-19 COVID-19 infection COVID-19 vaccine disease Effect effort groups help Heterologous immune modulation Immunity IMPROVE long-term adverse effects pandemic protocol reduce registries risk syndrome synergistic Tolerability translation unmet need vaccination Vaccine while [DOI] 10.1007/s00296-022-05157-6 PMC 바로가기
RASCL: Rapid Assessment of Selection in CLades through molecular sequence analysisArticle Published on 2022-11-022022-11-16 Journal: PLoS ONE [Category] SARS, 변종, 치료기술, [키워드] acting Analysis assessment automatically COVID-19 pandemic dataset datasets detect evaluate Evolution Genome Genome sequences genomes genomic include Intensive Lineage lineages molecular Mutation natural selection Notation object pathogen Phylogenetic Rapid SARS-CoV-2 selected Selection selective sensitivity sequence Sequence analysis sequencing error Surveillance underlie unmet need variants of concern whole genes yielding [DOI] 10.1371/journal.pone.0275623 PMC 바로가기
The current status of thrombosis and anticoagulation therapy in patients with COVID-19 in Japan: From the CLOT-COVID studyObservational Study Published on 2022-10-012022-10-05 Journal: Journal of cardiology [Category] COVID19(2023년), SARS, 임상, [키워드] Anticoagulant Anticoagulants anticoagulation Asian bleeding Computed tomography coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection diagnosed with COVID-19 died disease dose enrolled hospital Hospitalization hospitalized patient incidence Japan Major management Mild Moderate COVID-19 multicenter cohort study occurred Patient patients with COVID-19 pharmacological Pneumonia polymerase chain positive proportion Respiratory failure retrospective severe COVID-19 severity the patient therapy Thromboprophylaxis thrombosis unmet need Venous Thromboembolism with COVID-19 [DOI] 10.1016/j.jjcc.2022.03.015 PMC 바로가기 [Article Type] Observational Study
Unmet needs in pneumonia research: a comprehensive approach by the CAPNETZ study groupArticle Published on 2022-09-102022-11-16 Journal: Respiratory Research [Category] SARS, 치료기술, [키워드] Acquired Acute respiratory infection Affect Antibiotic treatment Antiviral approach asked Biomarkers CAP pathogens changed community-acquired pneumonia Comorbidities Comorbidity complex complications computer scientist database DelPhi diagnostics disease epidemiologists Europe Guidance Health Host identify imaging immune response immune system Immune-compromised host improvement Influenza internal and external knowledge machine machine learning Mortality next generation sequencing Pathogens patients Personalized medicine Physicians pneumococcal vaccines Pneumonia public health Research resolved risk risk stratification SARS-CoV-2 pandemic second Sequencing shown study group systemic and local The “omics” approach the patient therapy Translational research Treatment Universal universal influenza vaccine unmet need Vaccine [DOI] 10.1186/s12931-022-02117-3 PMC 바로가기
Stroke Family Caregiver Life Changes From the COVID-19 PandemicRandomized Controlled Trial Published on 2022-08-012022-10-05 Journal: International journal for equity in health [Category] 임상, [키워드] activities activity added affected Analysis analyzed approach assessment Care Caregiver change changes changes in conducted Consensus Controlled clinical trial COVID-19 COVID-19 pandemic Data analysis determine emotional family feasibility finding Healthcare provider indicated Internet life Masks negative negative and positive problem qualitative data Quantitative Randomized reduced resource response resulting scale selected social contact Stress stroke survivor telehealth unmet need [DOI] 10.1097/JNN.0000000000000654 PMC 바로가기 [Article Type] Randomized Controlled Trial
Effects of non-steroidal anti-inflammatory drugs and other eicosanoid pathway modifiers on antiviral and allergic responses: EAACI task force on eicosanoids consensus report in times of COVID-19비스테로이드성 소염제 및 기타 에이코사노이드 경로 조절제가 항바이러스 및 알레르기 반응에 미치는 영향: COVID-19 시대의 에이코사노이드 합의 보고서에 대한 EAACI 태스크포스Article Published on 2022-08-012022-09-11 Journal: Allergy [Category] COVID19(2023년), SARS, 치료제, [키워드] allergic allergic diseases allergic inflammation allergy analgesic effect antagonist Anti-inflammatory anti-inflammatory drug Antipyretic Antiviral applied Asthma Biologicals biologicals. cannabinoids chronic inflammatory disease Consensus COVID-19 COVID-19 treatment Effect eicosanoid General population Horizon identify Inflammation Inflammatory diseases Interaction knowledge leukotriene leukotriene receptor antagonist leukotriene receptor antagonists LTRA mechanism mechanism of action medication medications NERD non-steroidal anti-inflammatory drug Non-steroidal anti-inflammatory drugs NSAID NSAIDS pandemic of COVID-19 pathway Pathways predict prostaglandin prostaglandin D2 Research Respiratory disease respiratory infections response SARS-CoV-2 selectivity Symptom therapy Treatment unmet need viral infection viral infections [DOI] 10.1111/all.15258 PMC 바로가기 [Article Type] Article
Single-cell sorting based on secreted products for functionally defined cell therapies Reviews Published on 2022-07-222022-10-05 Journal: Microsystems & Nanoengineering [Category] 바이오마커, [키워드] accumulating addition Analysis approach approaches autoimmune disorder Cell Cell therapy cellular cellular therapy Critical defined disease Efficacy exacerbated fibrosis functional Genetic Hematological malignancies in vivo individual cell killing labeling lack Migration molecular neurodegenerative disorder patients proliferation remained reporter robust secreted secretion Single Cell single-cell solid tumor therapeutic therapeutic potential Therapies therapy triggering unmet need while [DOI] 10.1038/s41378-022-00422-x [Article Type] Reviews
A structural homology approach to identify potential cross-reactive antibody responses following SARS-CoV-2 infection Research Published on 2022-07-062022-10-05 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 바이오마커, 치료제, [키워드] anti-SARS-CoV-2 antibody approach clinical observation clinical presentation contribute COVID-19 Critical cross-react cross-reactive antibody disease domain driving epitope evaluate function human protein human proteins Hypothesis identify indication linear epitopes novel SARS-CoV-2 virus Pathologies pathology Protein response SARS-COV-2 infection SARS-CoV-2 protein SARS-CoV-2 Wuhan strain structural homology Therapies understanding unmet need with COVID-19 [DOI] 10.1038/s41598-022-15225-3 [Article Type] Research
Efficacy and safety of a single dose of casirivimab and imdevimab for the prevention of COVID-19 over an 8-month period: a randomised, double-blind, placebo-controlled trialRandomized Controlled Trial Published on 2022-07-052022-10-05 Journal: The Lancet. Infectious Diseases [Category] COVID19(2023년), SARS, 변종, 임상, 진단, [키워드] 1:1 active against addition age Analysis assigned B.1.1.529 baseline Community Complete COVID-19 COVID-19 symptom COVID-19 vaccination COVID-19 vaccine death diagnostic dose double-blind drugs Efficacy Endpoint expected finding follow-up period funding Health healthy Hoffmann-La Roche hospitalised household contact immune response incidence infected individuals Infectious diseases investigator Local monoclonal antibody combination mounted occurred participant patient population Placebo placebo-controlled trial post-hoc post-hoc analysis prespecified analysis prevented prevention of COVID-19 Prophylaxis proportion provided randomisation randomised Randomly receive receiving reduced Regeneron Pharmaceuticals Registered reported risk of COVID-19 risk reduction Romania RT-PCR testing SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected individual Seroconversion seronegative seropositive shown single dose strain stratified subcutaneous injection susceptible symptomatic SARS-CoV-2 infection the placebo group timepoint treatment-emergent adverse event treatment-emergent adverse events uninfected unmet need USA variants waned [DOI] 10.1016/S1473-3099(22)00416-9 [Article Type] Randomized Controlled Trial