UPR – Communicable Diseases Research

SARS-CoV-2 Diverges from Other Betacoronaviruses in Only Partially Activating the IRE1α/XBP1 Endoplasmic Reticulum Stress Pathway in Human Lung-Derived Cells

Article

Published on 2022-10-262022-11-15
Journal: mBio [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, 치료기술,

Live and let die: signaling AKTivation and UPRegulation dynamics in SARS-CoVs infection and cancer

Article

Published on 2022-10-032022-11-16
Journal: Cell Death & Disease [Category] COVID19(2023년), SARS, 신약개발, 유전자 메커니즘,

Impact of SARS-CoV-2 RBD Mutations on the Production of a Recombinant RBD Fusion Protein in Mammalian Cells

Article

Published on 2022-08-242022-11-16
Journal: Biomolecules [Category] SARS, 변종,

Repurposing the Antiplatelet Agent Ticlopidine to Counteract the Acute Phase of ER Stress Condition: An Opportunity for Fighting Coronavirus Infections and Cancer

응급실 스트레스 상태의 급성기에 대응하기 위해 항혈소판제 티클로피딘의 용도 변경: 코로나바이러스 감염 및 암 퇴치를 위한 기회

Article

Published on 2022-07-062022-09-11
Journal: Molecules [Category] COVID19(2023년), SARS, 신약개발,

[키워드] Achille agent antiplatelet Antiplatelet agent approach approved drugs attribute Cancer Cancer cells Cell Coronavirus infections Coronavirus-2 COVID-19 demonstrated Endoplasmic reticulum endoplasmic reticulum (ER) ER membranes ER stress exacerbating Fighting heel homeostasis life cycle Metastasis Modification modulation opportunity P2Y12 P2Y12 inhibitors pathological conditions Perturbation phase promote receptor representing repurposing responsible SARS Coronavirus SARS-CoV-2 sigma sigma 1 receptor (S1R) terminal UPR the disease therapeutic intervention Therapies ticlopidine ticlopidine. Tumor tumor growth unfolded protein response UPR viral glycoprotein viral glycoproteins viral infection viral infections viral life cycle
[DOI] 10.3390/molecules27144327 PMC 바로가기 [Article Type] Article

The Role of Unfolded Protein Response in Coronavirus Infection and Its Implications for Drug Design

Microbiology

Published on 2021-12-242022-10-31
Journal: Frontiers in Microbiology [Category] COVID-19,

SARS-CoV-2 ORF3a Induces Incomplete Autophagy via the Unfolded Protein Response

Article

Published on 2021-12-092022-10-28
Journal: Viruses [Category] COVID-19, SARS,

The PERK/PKR-eIF2α Pathway Negatively Regulates Porcine Hemagglutinating Encephalomyelitis Virus Replication by Attenuating Global Protein Translation and Facilitating Stress Granule Formation

Cellular Response to Infection

Published on 2021-10-132022-10-30
Journal: Journal of Virology [Category] Coronavirus, MERS,

[키워드] activate activated activating Activation acute respiratory syndrome addition antiviral drugs antiviral role Betacoronavirus cause caused Cell Characteristics coronavirus Coronavirus replication coronavirus-infected cell coronavirus-infected cells Coronaviruses decrease disease Diseases double-stranded eIF2α eIF2α Encephalomyelitis Endoplasmic reticulum endoplasmic reticulum stress ER stress facilitate Facilitating Formation Granule high mortality rate Host Human in vitro in vivo infected cells Infection inhibited innate response Interaction interferon invading pathogen mechanism MERS-CoV Middle East modulate nerve cell neurotropic new treatment strategy Occurrence outcome pathogenic pathway Phosphorylation PKR porcine hemagglutinating encephalomyelitis virus promoted Protein protein translation regulate regulated Replication repressed respiratory syndrome coronavirus reveal SARS-CoV SARS-CoV-2 signaling pathway specific treatment stress granule suppressed target translation attenuation triggered turn unfolded protein response UPR viral proliferation viral replication virus
[DOI] 10.1128/JVI.01695-21 PMC 바로가기 [Article Type] Cellular Response to Infection

Pneumocytes are distinguished by highly elevated expression of the ER stress biomarker GRP78, a co-receptor for SARS-CoV-2, in COVID-19 autopsies

폐렴 세포는 COVID-19 부검에서 SARS-CoV-2의 공동 수용체인 ER 스트레스 바이오마커 GRP78의 고도로 상승된 발현으로 구별됩니다

Article

Published on 2021-09-012022-09-11
Journal: Cell stress & chaperones [Category] SARS, 치료기술, 치료법, 치료제,

[키워드] acute respiratory distress syndrome age alveolar damage ARDS Autopsy Biomarker cellular Co-receptor controls COVID-19 COVID-19 patient death rate death rates Deceased Degradation determined by distress edema elevated ER stress examined exhibited expression feature Gender Glucose GRP78 Host hyaline membrane hyaline membrane formation immune modulation immunohistochemical staining immunostaining implicated independent independent of Inflammation Interaction lung Lung injury Lungs Macrophage macrophages modulate morbidity morbidity and mortality Non-COVID-19 nucleocapsid protein overlap overlapped pathway pneumocyte Pneumocytes Protein Proteostasis receptor reducing Resilience respiratory distress Respiratory distress syndrome robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections severe lung injury staining surgical resection syndrome therapeutic strategy tissue repair unfolded protein response UPR Vaccinations was increased
[DOI] 10.1007/s12192-021-01230-4 PMC 바로가기 [Article Type] Article

Endoplasmic reticulum stress and NF‐kB activation in SARS‐CoV ‐2 infected cells and their response to antiviral therapy

SARS-CoV-2 감염 세포에서 소포체 스트레스와 NF-kB 활성화와 항바이러스 치료에 대한 반응

Special Issue

Published on 2021-08-132022-09-10
Journal: Iubmb Life [Category] MERS, SARS, 치료제,

[키워드] Activation antiviral therapy c‐Jun caspase Cell cell interaction cells cellular cellular processe cellular stress response change characterized COVID‐19 cytopathic Endoplasmic reticulum expression host cell hpi identify inducer infected cell infection process Inflammation Inflammatory inhibition Interaction investigated MAPK MAPK signaling molecular nelfinavir NF‐kB occur Pathogenesis pathway Protease inhibitor Protein protein expression Remdesivir SARS‐CoV‐2 infection SARS‐CoV‐2 Signal transduction Signaling stimulate Stress stress response therapy transcriptional regulation unfolded protein response UPR VERO‐E6 cells Viral viral infection viral replication virus
[DOI] 10.1002/iub.2537 PMC 바로가기 [Article Type] Special Issue

Unfolded Protein Response Inhibition Reduces Middle East Respiratory Syndrome Coronavirus-Induced Acute Lung Injury

Research Article

Published on 2021-08-102022-10-29
Journal: mBio [Category] COVID-19, MERS,

[키워드] acute lung injury alleviate Analysis Apoptosis approved Cell culture contribute coronavirus Critical Cytopathic effect data set demonstrated disease Endothelial cell expression pattern fibroblast fibroblasts functional enrichment HAE Host host response human airway epithelial human lung individuals inhibition Interaction Intervention kinetic lung lung cell Lung disease male mechanism MERS-CoV MERS-CoV infection mice microvascular endothelial cells Middle East Outbreaks outcomes pathway patients Pharmacologic primary human lung cells progression Protein proteomes provide reduced reductions in regulated replicate replication kinetics respiratory Respiratory function respiratory syndrome coronavirus response Stress Symptom System tissue transcript transcriptomes unfolded protein response UPR validation study viability viral titer virus infection weight loss were infected
[DOI] 10.1128/mBio.01572-21 PMC 바로가기 [Article Type] Research Article