Immunogenicity and protection efficacy of a COVID-19 DNA vaccine encoding spike protein with D614G mutation and optimization of large-scale DNA vaccine productionArticle Published on 2024-06-152024-09-05 Journal: Scientific Reports [Category] update2024, [키워드] DNA vaccine downstream Drug discovery K18-hACE2 transgenic mice Large-scale production Microbiology SARS-CoV-2 upstream [DOI] 10.1038/s41598-024-64690-5 PMC 바로가기 [Article Type] Article
Microbial astaxanthin: from bioprocessing to the market recognitionMini-Review Published on 2023-05-262024-09-05 Journal: Applied Microbiology and Biotechnology [Category] update2024, [키워드] astaxanthin downstream Haematococcus pluvialis Health market Microbial sources Phaffia rhodozyma upstream [DOI] 10.1007/s00253-023-12586-1 PMC 바로가기 [Article Type] Mini-Review
Prevalence and Correlates of SARS CoV-2 Among a Community-Based Sample Recruited Using Randomized Venue-Based Sampling. Essex County, NJ, 2020Article Published on 2022-12-012022-11-15 Journal: Journal of racial and ethnic health disparities [Category] COVID19(2023년), SARS, 진단, [키워드] antibody black blood sample Care Community conducted correlates COVID-19 death determine Diagnosis disease Disparities disparity Factor help identify Infection Latinx morbidity and mortality New no significant difference outcome participant Participants PCR testing positive Prevalence provided public health reflected Sample sampling SARS CoV-2 SARS-CoV-2 antibodies Seroprevalence stick suggested Surveillance Testing the disease Treatment underlying conditions upstream USA virus [DOI] 10.1007/s40615-021-01175-5 PMC 바로가기
A Meta-summary and Bioinformatic Analysis Identified Interleukin 6 as a Master Regulator of COVID-19 Severity BiomarkersResearch article Published on 2022-11-012022-10-05 Journal: Cytokine [Category] 바이오마커, 임상, 진단, 치료기술, [키워드] addition approach Bioinformatic Bioinformatics analysis Biomarker Biomarkers candidate Compound conserved COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 severity Cytokine storm Cytokines dataset datasets disease severity enriched biological processe extreme highlight Identified identify IL6 immunological reaction include Inflammatory biomarker Inflammatory response interleukin 6 Isolation neurological Patient physiological system Prognosis Prognostic markers progression Protein proteomics regulator rising robust screening methods severity Therapeutic approach treating COVID-19 Treatment upstream validation study [DOI] 10.1016/j.cyto.2022.156011 [Article Type] Research article
Adding colchicine to tocilizumab in hospitalized patients with severe COVID-19 pneumonia: An open-label randomized controlled trialArticle Published on 2022-09-302022-11-15 Journal: Medicine [Category] SARS, 진단, [키워드] 1:1 added Adding Analysis antagonists Anti-inflammatory anti-inflammatory agent approved cascade center Colchicine Corporation cytokine Cytokine storm Efficacy and safety Ethics evaluate hospitalized patient IL-6 IL-6 blockade include Inflammasome inhibiting institutional review board Invasive mechanical ventilation Local mechanism of action Mortality NLRP3 Open-label Patient peer-reviewed Primary outcome Randomized Randomized controlled trial receptor receptor protein reduce Result risk safety profile severe COVID-19 Severe COVID-19 pneumonia Study protocol submitted Tocilizumab upstream [DOI] 10.1097/MD.0000000000030843 PMC 바로가기
Deciphering SARS CoV-2-associated pathways from RNA sequencing data of COVID-19-infected A549 cells and potential therapeutics using in silico methodsArticle Published on 2022-09-022022-11-16 Journal: Medicine [Category] SARS, 유전자 메커니즘, [키워드] A549 cell activated Activation acute respiratory syndrome addition Analysis Atypical candidate caused characterized CLC complications CoV COVID COVID-19 COVID-19 infection cytokine deaths DEGs Determining differentially expressed gene disease drug effective experimental validation Gene Expression Omnibus gene signatures Genomics GEO GSE147507 human-to-human transmission identify IFNβ IL-17 IL-1β Illumina in silico In silico method influenza A Interaction interferon beta interferon regulatory factor IRF3 IRF9 JQ1 knowledge mechanism Methylprednisolone mock-treated pathology pathway Pneumonia Prednisolone Quality control receptors RNA RNA sequencing RNA sequencing data SARS CoV-2 signaling pathway signaling pathways small molecule STAT2 the Coronaviridae the disease therapy Transcription Treatment underlying disease upstream Viral protein virus infection was used with COVID-19 Wuhan, China [DOI] 10.1097/MD.0000000000029554 PMC 바로가기
C5a elevation in convalescents from severe COVID-19 is not associated with early complement activation markers C3bBbP or C4dArticle Published on 2022-08-242022-11-15 Journal: Frontiers in Immunology [Category] SARS, 바이오마커, [키워드] Activation Alternative pathway Analysis anaphylatoxin C4d C5a Clinical course clinical risk clinical risk score collected complement Complement pathway complement system convalescent correlation Course COVID-19 disease severity elevated evaluated Follow-up groups highest hospital discharge Hospitalization infected with SARS-CoV-2 marker Numerous pathway Patient positive correlation reported severe COVID-19 severely ill patient severity soluble fraction suffered the disease the patient upstream were assessed [DOI] 10.3389/fimmu.2022.946522 PMC 바로가기
Multiomic analysis reveals cell-type-specific molecular determinants of COVID-19 severity다중체 분석은 COVID-19 중증도의 세포 유형별 분자 결정 요인을 나타냅니다.Article Published on 2022-08-172022-10-30 Journal: Cell Systems [Category] COVID-19, MERS, 바이오마커, 변종, 유전자 메커니즘, [키워드] Analysis CD56 Cell cell types COVID-19 COVID-19 severity cytokine determinant determinants dysfunction enrichment functions gene discovery Genes Genetic genetic risk Genetic variation genome-wide association Genome-wide association study genomic GWAS healthy human lung innate immune response Intervention limit machine learning mendelian randomization molecular natural killer network analysis NK cell NK cells NK-cell Pathogenesis potential therapeutic targets provide rare variant analysis reveal risk severe COVID-19 severe disease single-cell single-cell multiomic profiling. Support T cells these cell These cells upstream variant [DOI] 10.1016/j.cels.2022.05.007 PMC 바로가기 [Article Type] Article
QTQTN motif upstream of the furin-cleavage site plays a key role in SARS-CoV-2 infection and pathogenesis푸린 절단 부위의 QTQTN 모티프는 SARS-CoV-2 감염 및 발병에 중요한 역할을 합니다Article Published on 2022-08-092022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] attenuate cleavage coronavirus CoVs Critical cultured virus deleting Deletion determine disease Disruption Efficiency Factor FCS furin furin cleavage site furin-cleavage site glycosylated glycosylation host proteases in vitro in vivo Infection isolates less motif mutant Pathogenesis peptide QTQTN reduced required residue residues respiratory respiratory cell respiratory cells S1/S2 cleavage S1/S2 cleavage site SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication SARS-CoV-2 spike protein spike Spike protein the SARS-CoV-2 TMPRSS2 upstream Viral viral replication virus replication [DOI] 10.1073/pnas.2205690119 PMC 바로가기 [Article Type] Article
Pyroptotic Patterns in Blood Leukocytes Predict Disease Severity and Outcome in COVID-19 Patients혈액 백혈구의 Pyroptotic 패턴은 COVID-19 환자의 질병 심각도와 결과를 예측합니다Article Published on 2022-07-192022-09-11 Journal: Frontiers in Immunology [Category] 유전자 메커니즘, [키워드] acute respiratory distress acute respiratory distress syndrome ARDS blood leukocyte caused Clinical treatment Cluster Clustering Compound coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients deaths detrimental effects differentially expressed gene Differentially expressed genes disease effective enrichment analysis expression gene set enrichment analysis Genes GSEA hyperinflammation hyperinflammatory state IMPROVE LASSO leukocyte leukocytes operator pandemic Patient patients pattern Prognosis prognosis model prognostic model proteomic pyroptosis respiratory distress Respiratory distress syndrome syndrome therapeutic transcription factor transcription factors transcriptomic data Unsupervised clustering upstream worse prognosis [DOI] 10.3389/fimmu.2022.888661 PMC 바로가기 [Article Type] Article