ORAL NEUROPATHIC PAIN POST-COVID-19 IN A YOUNG BRAZILIAN PATIENTConference abstract Published on 2022-09-012022-10-05 Journal: Oral surgery, oral medicine, oral pathology and or [Category] 변종, [키워드] Anosmia complication of COVID-19 complications Concentration concerning cough COVID-19 cytidine develop disease fatigue information knowledge Medicine memory myalgia nasal congestion neurologic neuropathic neuropathic pain oral oral examination osseous Pain patients with COVID-19 positive presenting reported service sore throat Treatment uridine vitamin B12 worsening [DOI] 10.1016/j.oooo.2022.01.079 [Article Type] Conference abstract
Flipped over U: structural basis for dsRNA cleavage by the SARS-CoV-2 endoribonuclease뒤집힌 U: SARS-CoV-2 엔도리보뉴클레아제에 의한 dsRNA 절단의 구조적 기초Article Published on 2022-08-122022-09-11 Journal: Nucleic Acids Research [Category] SARS, 유전자 메커니즘, 치료법, [키워드] activate Activation active site cleavage cleave coronavirus Coronavirus replication Critical cryo-EM structure cryo-EM structures double-stranded dsRNA endoribonuclease evade form generate Host immune MDA5 mechanism Nsp15 Pattern recognition pattern recognition receptor platform processing recognize replication-transcription complex RNA SARS-CoV-2 SARS-CoV-2 Nsp15 single-stranded site-directed mutagenesis structures substrates the SARS-CoV-2 uridine Vesicle viral replication [DOI] 10.1093/nar/gkac589 PMC 바로가기 [Article Type] Article
Rhabdomyolysis-Induced AKI (RIAKI) Including the Role of COVID-19COVID-19의 역할을 포함한 횡문근 융해 유발 AKI(RIAKI)Review Published on 2022-07-262022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), MERS, SARS, 바이오마커, 치료기술, [키워드] acute kidney Acute kidney injury acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration AKI aspartate Aspartate aminotransferase AST bloodstream caused Cell combination therapy Complication contribute coronavirus Course COVID-19 COVID-19 disease creatine creatine kinase damage defined develop Diagnosis disease drugs escape Factors FIVE Fluid resuscitation furosemide high mortality rate in some Including Lactate lactate dehydrogenase LDH life-threatening limit mannitol many cases marker muscle pain Myoglobin occur Pain Patient patients Potassium renal renal replacement therapy replacement therapy required respiratory rhabdomyolysis role RRT SARS-CoV-2 serious complication serum severe acute respiratory syndrome Coronavirus Side effect Side effects sodium sodium bicarbonate statin Striated muscle therapeutic interventions therapy Treatment uridine [DOI] 10.3390/ijms23158215 PMC 바로가기 [Article Type] Review
Diagnosis and prognosis of COVID-19 employing analysis of patients’ plasma and serum via LC-MS and machine learningLC-MS 및 머신러닝을 통한 환자의 혈장 및 혈청 분석을 통한 코로나19 진단 및 예후Article Published on 2022-07-012022-09-11 Journal: Computers in biology and medicine [Category] COVID19(2023년), MERS, SARS, 바이오마커, 변종, 진단, 치료기술, [키워드] Accuracy acetyl Algorithm Analysis analyzed best Biomarker Biomarkers caused China controls COVID COVID 19 COVID-19 COVID-19 diagnosis COVID-19 patient datasets Diagnosis evaluate evaluated fatality glucosamine greater healthy volunteer healthy volunteers help hospital independent l-ornithine LC-MS machine machine learning material metabolite methyl isobutyrate negative RT-PCR outcomes Patient patients with COVID-19 patients with pneumonia phosphate plasma Pneumonia predict Prognosis prognostic indicator RT-PCR Sample SARS-CoV-2 serum severity significantly SVM the disease uridine virus viruses were used with COVID-19 [DOI] 10.1016/j.compbiomed.2022.105659 PMC 바로가기 [Article Type] Article
Concise synthesis of antiviral drug, molnupiravir by direct coupling of fully protected d-Ribose with cytosineShort communication Published on 2022-05-012022-10-05 Journal: Tetrahedron Letters [Category] 치료제, [키워드] Anti-viral antiviral drug cytidine cytosine d-Ribose effective expand expected group groups hydrolysis hydroxy less molnupiravir Ribonucleoside uridine [DOI] 10.1016/j.tetlet.2022.153783 [Article Type] Short communication
mRNA vaccines against COVID-19: a showcase for the importance of microbial biotechnologyCOVID-19에 대한 mRNA 백신: 미생물 생명공학의 중요성에 대한 쇼케이스Article Published on 2022-01-012022-09-11 Journal: Microbial Biotechnology [Category] SARS, 변종, [키워드] Adverse reaction Adverse reactions Alpha Beta variant booster chills Coverage COVID-19 CureVac delta variant Delta variants Efficacy Extensive Facial nerve facial nerve paralysis fatigue Fever Formulation group headache increase in Infection injection injection site pain lipid composition male microbial Mild Moderna mRNA mRNA vaccine mRNA vaccines muscle pain myocarditis nanoparticle nerve paralysis neutralization observational studies observational study Older Pain Pfizer-BioNTech phase Population pseudouridine replacement risk safety profile SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 spike protein severe COVID-19 Spike protein subject Surveillance symptomatic disease the SARS-CoV-2 uridine Vaccine vaccine trial variant viruses [DOI] 10.1111/1751-7915.13974 PMC 바로가기 [Article Type] Article
Molecular Docking and Dynamics Investigations for Identifying Potential Inhibitors of the 3-Chymotrypsin-like Protease of SARS-CoV-2: Repurposing of Approved Pyrimidonic Pharmaceuticals for COVID-19 TreatmentSARS-COV-2의 3- chymotrypsin- 유사 프로테아제의 잠재적 억제제를 식별하기위한 분자 도킹 및 역학 조사 : Covid-19 치료를위한 승인 된 피리 미도 론적 제약의 재구성Article Published on 2021-12-092022-08-31 Journal: Molecules [Category] SARS, 신약개발, 치료제, [키워드] 3-chymotrypsin-like protease 3CL pro active site active sites approved binding binding affinity binding energy binding free energy catalytic catalytic dyad chymotrypsin citicoline complexes conformation coronavirus SARS-CoV-2 COVID-19 Cys145 cytarabine determined by docked complex drug Drug administration Dynamics Floxuridine food free energy His41 identifying inhibitory effect investigation involved lamivudine molecular molecular docking molecular dynamics molecular dynamics simulations Molecular mechanics mustard pharmaceutical Potential protease pyrimidonic pharmaceuticals ranged repurposing residue residues SARS-CoV-2 stability stavudine surface area telbivudine tested tipiracil trifluridine uracil uracil mustard uridine uridine triacetate US Food and Drug Administration zalcitabine [DOI] 10.3390/molecules26247458 PMC 바로가기 [Article Type] Article
The New Generation h DHODH Inhibitor MEDS433 Hinders the In Vitro Replication of SARS-CoV-2 and Other Human CoronavirusesArticle Published on 2021-08-142022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] hDHODH inhibitor addition Anti-SARS-CoV-2 Activity Antiviral antiviral activity antiviral agent biosynthesis pathway broad-spectrum antiviral cells cellular combination treatment contribute coronavirus CoV COVID-19 CoVs de novo develop development DHODH drug effective embryonic enzyme Generation Human in vitro infections inhibited inhibitor kidney organoid lack New organoids Other pandemic Pandemics predicted prevented Probability pyrimidine biosynthesis Replication reversed SARS-CoV-2 stem cells therapeutic intervention Threats uridine zoonotic disease [DOI] 10.3390/microorganisms9081731 PMC 바로가기 [Article Type] Article
Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis몰누피라비르 유발 SARS-CoV-2 돌연변이 유발 메커니즘Article Published on 2021-08-112022-09-10 Journal: Nature Structural & Molecular Biology [Category] MERS, SARS, 변종, 유전자 메커니즘, 치료제, [키워드] (RdRp (RdRp) active form Analysis animal model animal models antiviral activity antiviral drug base pair base pairs biochemical assay cause complexes COVID-19 Cryo-EM analysis Cryoelectron microscopy cytidine cytidine triphosphate explain Frequency High-resolution humans impair incorporation increase mechanism molecular mechanism molecular mechanisms molnupiravir Mutagenesis mutated Mutation NHC patients with COVID-19 phase III trial Phase III trials polymerase Proofreading RdRP resulting RNA RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 mutagenesis SARS-CoV-2 replication Structural analysis substrate Template Treatment triphosphate uridine uridine triphosphate Viral Viral mutagenesis Viral RNA viral RNA-dependent RNA polymerase [DOI] 10.1038/s41594-021-00651-0 PMC 바로가기 [Article Type] Article
Identification of potential inhibitors of SARS-COV-2 endoribonuclease (EndoU) from FDA approved drugs: a drug repurposing approach to find therapeutics for COVID-19FDA 승인 약물로부터 SARS-COV-2 엔도 리보 뉴 클레아 제 (ENDOU)의 잠재적 억제제의 확인 : COVID-19에 대한 치료제를 찾기위한 약물 재구성 접근법Article Published on 2021-08-012022-08-31 Journal: Journal of biomolecular structure & dynamics [Category] MERS, SARS, 신약개발, 치료제, [키워드] active site Amino acid amino acid residues antiviral drug approach approved binding binding affinity binding free energies binding free energy calculated catalytically causative agent Clinical efficacy Comparative Compound COVID-19 diabete diabetes dose drug Drug development Drug repurposing ENCODE endonuclease EndoU enzyme essential amino acid FDA free energies Glisoxepide IC50 Idarubicin identification in silico inhibitor intermolecular interaction leukemia life cycle molecular molecular dynamic simulation molecular dynamics monophosphate Nsp15 performed predicted required responsible ribonucleotide SARS-CoV-2 selected Simulation study Structural analysis suggested surface area therapeutic therapeutic option treat Treatment uridine uridine monophosphate Vaccine Viral Virtual screening Virus life cycle [DOI] 10.1080/07391102.2020.1775127 PMC 바로가기 [Article Type] Article