Successful high flow nasal cannula therapy for severe COVID-19 pneumonia is associated with tocilizumab use중증 COVID-19 폐렴에 대한 성공적인 고유량 비강 캐뉼라 요법은 토실리주맙 사용과 관련이 있습니다.Article Published on 2022-05-012022-09-12 Journal: Infectious diseases now [Category] MERS, 진단, [키워드] absence Admission age anti-IL6 AOR applied cohort study COVID-19 CT scan death defined determine drugs facial failure HFNO High flow nasal cannula hospital Hospital admission mechanical ventilation nasal Oxygen therapy Patient patients patients with COVID-19 randomized study respiratory Respiratory failure respiratory rate risk factor severe COVID-19 Severe COVID-19 pneumonia steroid treatment Steroids the disease therapeutic therapy thromboembolic complications Tocilizumab tocilizumab administration Treatment use of steroid was performed [DOI] 10.1016/j.idnow.2022.02.006 PMC 바로가기 [Article Type] Article
Tocilizumab in addition to standard of care in the management of COVID-19: a meta-analysis of RCTsCOVID-19 관리에서 표준 치료에 추가된 Tocilizumab: RCT의 메타 분석Meta-Analysis Published on 2022-03-142022-09-11 Journal: Acta bio-medica : Atenei Parmensis [Category] 임상, 진단, [키워드] 28-day mortality 95% CI addition Admission adverse event adverse events Analysis baseline benefit carried clinical benefit clinical benefits Cochrane Library control group Controlled controlled trials coronavirus disease Coronavirus disease 2019 COVID-19 defined Direct eligible event ICU ICU admission identify include initial intensive care intensive care unit less management mechanical ventilation Meta-analysis Mortality nine Occurrence Odds ratio outcome overall mortality participant Participants Patient performed Primary outcome progression randomization Randomized RCT RCTs receiving Science Science Direct secondary Secondary outcomes serious infection serious infections severe disease Standard of care statistically significant Steroids Subgroup analyses survival systematic review Tocilizumab use of steroid [DOI] 10.23750/abm.v93i1.12208 PMC 바로가기 [Article Type] Meta-Analysis
Cardiac inflammation and microvascular procoagulant changes are decreased in second wave compared to first wave deceased COVID-19 patients심장 염증 및 미세혈관 응고촉진제 변화는 1차 물결로 사망한 COVID-19 환자에 비해 2차 물결에서 감소Article Published on 2022-02-152022-09-12 Journal: International journal of cardiology [Category] COVID19(2023년), SARS, 진단, [키워드] accompanied addition analyzed Anticoagulant cardiac Cardiac pathology CD3+ CD45+ CD68+ change CML Cohort control patient COVID-19 COVID-19 patient COVID-19 patients Deceased decrease disease course DPP4 dysfunction Evidence Factor factor VII factor XII fatal COVID-19 First and second wave First wave heart infiltration Inflammation Injury leukocyte lymphocyte lymphocytic myocarditis Macrophage majority marker Microvascular thrombosis Mortality Necrosis Non-COVID-19 Occurrence pandemic patients peptidase procoagulant procoagulant factor Protein quantified reported second wave shown significant decrease significantly significantly lower T lymphocyte Thrombosis microvasculature. Treatment use of steroid [DOI] 10.1016/j.ijcard.2021.11.079 PMC 바로가기 [Article Type] Article
A guide to immunotherapy for COVID-19 Reviews Published on 2022-01-212022-10-05 Journal: Nature Medicine [Category] 바이오마커, 임상, 치료법, 치료제, [키워드] Algorithm anti-cytokine therapies clinical trial COVID-19 dysregulation Evidence help heterogeneity immune-based therapy Immunotherapy pathophysiology Patient patients with COVID-19 phenotype reported review severe infections Stratification Support the disease therapy Treatment Trial use of steroid [DOI] 10.1038/s41591-021-01643-9 [Article Type] Reviews
Use of steroids in COVID-19 patients: A meta-analysisResearch article Published on 2022-01-012022-10-05 Journal: European journal of pharmacology [Category] SARS, 신약개발, 임상, [키워드] 95% confidence interval Alter Analysis association benefit calculated clinical clinical evidence COVID-19 COVID-19 patient COVID-19 patients death deaths Dexamethasone drugs exclusion criteria Google hospitalized COVID-19 patient Hydrocortisone Inclusion Man Meta-analysis Methylprednisolone Odds ratio Patient Physicians Quantitative analysis reduce reduction in required Result searched sensitivity sensitivity analysis shown steroid Steroids subgroup analysis The Rev Trial use of steroid was done was used [DOI] 10.1016/j.ejphar.2021.174579 [Article Type] Research article
New insights on mucormycosis and its association with the COVID-19 pandemicReview Published on 2021-12-162022-10-31 Journal: Future Science OA [Category] COVID-19, [키워드] Abstract association can be used clinician correlation COVID-19 COVID-19 pandemic Diagnosis elevated Epidemiology Factors fatality Fungal infection healthcare help Host immune response immune dysregulation Infection management Mucormycosis New Pathogenesis recommendation Risk factors Secondary infection Treatment use of steroid virus [DOI] 10.2144/fsoa-2021-0122 PMC 바로가기 [Article Type] Review
Short-Course of Methylprednisolone Improves Respiratory Functional Parameters After 120 Days in Hospitalized COVID-19 Patients (Metcovid Trial): A Randomized Clinical TrialMedicine Published on 2021-11-302022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] acute phase Admission Analysis benefit Brazil carried clinical clinical trial conducted coronavirus Corticosteroid COVID-19 Day double-blind evaluated expiratory fibrosis Follow-up functions FVC group help Hospital admission hospitalized COVID-19 patient hospitalized patient ICU IIb IL-6 level impairment IMV Inflammation Invasive mechanical ventilation less long-COVID Methylprednisolone Older parameter participant Patient patients Placebo placebo-controlled Primary outcome pulmonary function parameters Pulmonary function test Pulmonary function testing Randomized respiratory Respiratory failure SARS-CoV-2 Seven severe COVID-19 significantly higher supplementary oxygen Supportive treatment survived surviving patient the cytokine storm Univariate analysis use of corticosteroid use of steroid Volume [DOI] 10.3389/fmed.2021.758405 PMC 바로가기 [Article Type] Medicine
Global Prevalence of COVID-19-Associated Mucormycosis (CAM): Living Systematic Review and Meta-AnalysisArticle Published on 2021-11-182022-10-30 Journal: Journal of Fungi [Category] COVID-19, [키워드] age all-cause mortality rate approach article clinical outcomes Coinfection Comprehensive COVID-19 COVID-19 diagnosis COVID-19 pandemic COVID-19 patient criteria database diabetes eligible epidemiological Epidemiological study Epidemiology for inclusion Fungal infection glycemic control Healthcare system high mortality rate highest Infection investigator Meta-analysis mortality rate Mucormycosis Mycoses Patient patients performed Prevalence Primary outcome recorded review rising Risk factors Sample size screened secondary outcome Seven systematic review the patient use of steroid was used WHO [DOI] 10.3390/jof7110985 PMC 바로가기 [Article Type] Article
COVID19 associated mucormycosis: Is GRP78 a possible link?COVID19 관련 점막 진균증: GRP78이 가능한 링크입니까?Review Published on 2021-10-012022-09-11 Journal: Journal of infection and public health [Category] SARS, 변종, [키워드] acidosis aspergillosis candidiasis chaperone common complement CoTH COVID19 Delta delta variant Factor feature ferritin Fungal infection fungal infections glucocorticoid Glucose GRP78 host receptor Immunity implicated incidence India Infection internal and external Invasion invasive involved life-threatening mechanism molecular molecular mechanism molecular mechanisms Mucorales Mucormycosis over-expressed pandemic Pathogenesis raised receptor Research second wave Steroids therapy Treatment use of steroid [DOI] 10.1016/j.jiph.2021.09.004 PMC 바로가기 [Article Type] Review
Herpes Simplex Virus Re-Activation in Patients with SARS-CoV-2 Pneumonia: A Prospective, Observational StudyArticle Published on 2021-09-072022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] Herpesviridae association clinical manifestation clinically Co-infection conducted consecutive patient detectable Encephalitis event Evidence Hepatitis Herpe herpes labialis High dose Hospitalized hospitalized COVID-19 patients HSV-1 IMV incidence increased risk Infection LDH Logistic regression analysis manifestation mechanical ventilation Modena Odds ratio participant Patient patients patients with COVID-19 patients with SARS-CoV-2 PCR plasma Pneumonia positive patient Prospective re-activation SARS-CoV-2 SARS-CoV-2 pneumonia severe pneumonia significantly simplex single-center study steroid steroid treatment Steroids Support tested The effect size Tocilizumab treated use of steroid Viremia [DOI] 10.3390/microorganisms9091896 PMC 바로가기 [Article Type] Article