Valproic acid – Communicable Diseases Research

Long-term analysis of the effects of COVID-19 in people with epilepsy: results from a multicenter on-line survey across the pandemic waves

Research article

Published on 2022-10-012022-10-05
Journal: Epilepsy & behavior : E&B
[Category] COVID19(2023년), SARS, 진단,

[키워드] 3CLproSARS-CoV-2-3-chymotrypsin-like protease affected age Analysis analyzed antiseizures medication Anxiety appear ASMantiseizures medication Assessing anxiety caused characteristics of patients chronic condition Chronic diseases Coronavirus disease 2019 COVID-19 COVID-19 diagnosis COVID-19coronavirus disease 2019 Deterioration Effect epilepsy evaluated Follow-up HDAChistone deacetylase HDACihistone deacetylase inhibitor Health status heterogenous higher risk histone deacetylase Histone deacetylase inhibitor ICUIntensive Care Unit individual intensive care unit Italy lockdown lombardy management Molecular diagnosis multicenter Nasopharyngeal swab overlapping pandemic Patient people with epilepsy populations positive Prevalence Psychological distress PWEpeople with epilepsy questionnaire recognize reported reported symptom Result risk factor SARS-COV-2 infection SARS-CoV-2 virus SARS-CoV-2-3-chymotrypsin-like protease Seizure severe COVID-19 severity of symptoms Sex sleep quality subject subjects Support survey Symptom Telemedicine Therapies treat treatment regimen Vaccines Valproic acid VPAValproic acid worldwide pandemic
[DOI] 10.1016/j.yebeh.2022.108900 [Article Type] Research article

Mechanistic insights of key host proteins and potential repurposed inhibitors regulating SARS-CoV-2 pathway

SARS-CoV-2 경로를 조절하는 주요 숙주 단백질 및 잠재적 용도 변경 억제제에 대한 기계론적 통찰력

Article

Published on 2022-07-052022-09-11
Journal: Journal of computational chemistry
[Category] COVID19(2023년), SARS, 변종, 신약개발, 치료제,

[키워드] acute respiratory syndrome camostat catalytic activity Clinical studies clinical study develop dissociation pathways drug drugs Efficacy eIF4E2 energetics finding HDAC2 Host host protein host proteins independent inhibitor inhibitors inhibitory involved Keeping Kinetics mechanism mechanisms Metadynamics molecular molecular dynamics molecular dynamics. MOST nafamostat pandemic paper pathway Pathways Patient Probability Protein Repurposed drugs residue residues SARS-CoV-2 Severe acute respiratory syndrome severe COVID-19 patients Silmitasertib Support target targets treat Vaccine Valproic acid variant Zotatifin
[DOI] 10.1002/jcc.26888 PMC 바로가기 [Article Type] Article

Exposure to valproic acid is associated with less pulmonary infiltrates and improvements in diverse clinical outcomes and laboratory parameters in patients hospitalized with COVID-19

Research Article

Published on 2022-01-272022-10-28
Journal: PLoS ONE
[Category] COVID-19, SARS,

[키워드] Admission age analyzed Asymptomatic biochemical cause clinical endpoint Clinical outcome clinical setting Control control patients cumulative death develop duration of symptom Effect Efficacy evaluate exposure to hospital ICU admission improvement in vitro In-hospital inflammatory parameters Laboratory laboratory parameter less lung infiltrate lung infiltrates lymphocyte monocyte multicenter Multivariate analysis no difference Non-COVID-19 outcome Patient patients hospitalized Protective pulmonary infiltrate receiving Result Retrospective study SARS-COV-2 infection serious COVID-19 severity Sex shown survival Treatment two groups Valproic acid were recorded with COVID-19 worsening
[DOI] 10.1371/journal.pone.0262777 PMC 바로가기 [Article Type] Research Article

Epigenetic targeting of the ACE2 and NRP1 viral receptors limits SARS-CoV-2 infectivity

ACE2 및 NRP1 바이러스 수용체의 후성적 표적화는 SARS-CoV-2 감염성을 제한합니다

Research

Published on 2021-10-112022-09-10
Journal: Clinical Epigenetics
[Category] MERS, SARS, 유전자 메커니즘, 치료제,

[키워드] 2-propylpentanoic acid ACE-2 ACE2 addition Affect angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 anti-inflammatory effect Antiviral approved BEAS-2B block Caco-2 Cell cell line cell lines cells Clinical use COVID-19 COVID-19 patients Cytokines dampen decrease dose-dependent manner downregulate effective elements Engagement Epigenetic expression genomic gRNA HCoV HCoV-229E HDAC HDAC inhibitor host protein Huh-7 hyperinflammation IL-6 impair Infection infectious virus infectious viruses Inflammatory cytokine Inflammatory cytokines Inflammatory response inhibit inhibition inhibitor inhibitory activity limit mechanism Messenger RNA mRNAs N protein neuropilin NRP1 Patient Post-infection priming protease Protease activity protein level protein levels receptor reduce reduced reducing Replication Result S protein Safe SARS-CoV-2 SARS-COV-2 infection Serine serine protease serine protease TMPRSS2 severity of COVID-19 shown significantly supplementary material TMPRSS2 TNF-α Treatment treatment for COVID-19 triggered Vaccine Valproic acid Viral viral spread virion virus virus viruses VSV
[DOI] 10.1186/s13148-021-01168-5 PMC 바로가기 [Article Type] Research

Potential repurposing of the HDAC inhibitor valproic acid for patients with COVID-19

COVID-19 환자를 위한 HDAC 억제제 발프로산의 잠재적인 용도 변경

Review

Published on 2021-05-052022-09-11
Journal: European journal of pharmacology
[Category] SARS, 신약개발,

[키워드] acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 anti-inflammatory effect cellular coronavirus disease Coronavirus-2 COVID-19 cytokine response distress drug Effect end-organ damage enzyme epilepsy expression HDAC HDAC inhibitor histone Histone deacetylase inhibitor immune Infection inhibitor mitigate modulate Patient patients with COVID-19 Potential Prevent reduce reducing required respiratory distress Respiratory distress syndrome SARS-CoV-2 SARS-CoV-2 viral Serine Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe COVID-19 therapeutic therapeutic approach therapeutic approaches therapeutic target therapy transmembrane serine protease transmembrane serine protease 2 Valproic acid Valproic acid.
[DOI] 10.1016/j.ejphar.2021.173988 PMC 바로가기 [Article Type] Review

Toxicity of psychotropic drugs in patients with COVID-19: A systematic review

Review article

Published on 2021-05-012022-10-05
Journal: General hospital psychiatry
[Category] 치료제,

Immunopharmacological management of COVID-19: Potential therapeutic role of valproic acid

Comment

Published on 2020-10-012023-07-06
Journal: Med Hypotheses
[Category] SARS,

[키워드] COVID-19 Cytokines immunomodulation immunopharmacology Mood stabilizers Valproic acid viral replication.
[DOI] 10.1016/j.mehy.2020.109891 PMC 바로가기 [Article Type] Comment

Interferon-Induced Transmembrane Protein (IFITM3) Is Upregulated Explicitly in SARS-CoV-2 Infected Lung Epithelial Cells

Immunology

Published on 2020-06-102022-11-01
Journal: Frontiers in Immunology
[Category] COVID-19, MERS, SARS,

Drug-Induced Liver Injury: An Institutional Case Series and Review of Literature

Case Report

Published on 2018-03-142023-08-30
Journal: Journal of investigative medicine high impact case
[Category] E형 간염,

[키워드] Amiodarone Drug-induced liver injury failure fluconazole liver Valproic acid
[DOI] 10.1177/2324709618761754 PMC 바로가기 [Article Type] Case Report