SARS-CoV-2 infection and replication kinetics in different human cell types: The role of autophagy, cellular metabolism and ACE2 expressionArticle Published on 2022-11-012022-11-16 Journal: Life sciences [Category] SARS, 유전자 메커니즘, [키워드] A549 ACE2 ACE2 expression angiotensin ATP synthase autophagy BEAS-2B Brain Caco-2 can be used Cell cell line cell lines cellular cellular metabolism COVID-19 COX endothelial energy metabolism evaluated expression level HEK-293 human cell human cell line in vitro intestine intrinsically investigated kidney liver mechanism metabolism Mitochondria mitochondrial metabolism modified cell line molecular mechanism mRNA expression NDUFS2 overexpressed overexpressing overexpression Protein Replication replication kinetics respiratory tract RT-qPCR SARS-COV-2 infection SARS-CoV-2 replication SH-SY5Y susceptibility susceptible cell TMPRSS2 TMPRSS2 expression uninfected cell various tissue viral infection Viral load viral replication were assessed western blot [DOI] 10.1016/j.lfs.2022.120930 PMC 바로가기
The Complexity and Multiplicity of the Specific cAMP Phosphodiesterase Family: PDE4, Open New Adapted Therapeutic ApproachesArticle Published on 2022-09-132022-11-16 Journal: International Journal of Molecular Sciences [Category] 변종, [키워드] Adapted CAMP Cancer cardiovascular diseases cascade cellular cGMP complex complexity contribute COVID-19 cyclic cyclic nucleotide phosphodiesterase (PDE) Depression diabetes disease drug design dysregulation emesis Evolution Fatty liver increases in Inflammation inhibitor Interaction interactome knowledge maintain malignancies multiplicity New nucleotide obesity organ Osteoporosis overcome pathologic Pathologies phosphodiesterase Phosphorylation physiological state problems receptors Regulation Research selective selective PDE4 inhibitor (PDE4-I). Signaling Specific subcellular Therapeutic approach tissue ulcerative colitis variant various tissue [DOI] 10.3390/ijms231810616 PMC 바로가기
Mesenchymal stem cell-derived extracellular vesicles for immunomodulation and regeneration: a next generation therapeutic tool? Reviews Published on 2022-07-042022-10-05 Journal: Cell Death & Disease [Category] 바이오마커, [키워드] adipose body fluid Bone marrow Cell Characteristics effector Evidence EVs extracellular vesicle fibrosis heterogeneity highlight immune regulation Intercellular communication mesenchymal stem cell molecular mechanism MSC MSCs overcome paracrine supernatants Support therapeutic therapeutic effect therapy tissue tissue repair Treatment umbilical various tissue Vesicle [DOI] 10.1038/s41419-022-05034-x [Article Type] Reviews
Pulmonary and Systemic Pathology in COVID-19Article Published on 2022-06-242022-11-15 Journal: Deutsches Ärzteblatt international [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] acute respiratory distress affected Alter Analysis Angiogenesis ARDS arise Autopsy Brain cardiovascular system Central nervous system change clinical picture concerning contribute COVID COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients disease Endothelium Evidence gastrointestinal tract interstitial invagination Ischemia kidneys liver Lungs mechanisms molecular organ organ damage outbreak pandemic pathophysiology Placenta pulmonary Regulatory retrieved risk factor selective severe cases syndrome systemic thrombosis tissue various tissue vessel [DOI] 10.3238/arztebl.m2022.0231 PMC 바로가기
Molnupiravir and Its Active Form, EIDD-1931, Show Potent Antiviral Activity against Enterovirus Infections In Vitro and In VivoMolnupiravir 및 활성 형태인 EIDD-1931, 시험관 내 및 생체 내 엔테로바이러스 감염에 대한 강력한 항바이러스 활성을 나타냄Article Published on 2022-05-252022-09-11 Journal: Viruses [Category] 치료제, [키워드] active form activity administration Analysis Antiviral antiviral drug approved aseptic meningitis children Concentration concentrations COVID-19 death disease drug candidate EIDD-1931 EIDD-2801 Encephalitis enterovirus expression foot form hand Health authority indicated Infant Infants Infection infections mechanism Meningitis mice molnupiravir myocarditis plasma drug potent progeny reduce reducing reported show significantly state Treatment treatment of COVID-19 United Kingdom various tissue various tissues Viral load Viral protein virus [DOI] 10.3390/v14061142 PMC 바로가기 [Article Type] Article
Neuropilin-1-Mediated SARS-CoV-2 Infection in Bone Marrow-Derived Macrophages Inhibits Osteoclast Differentiation골수 유래 대식세포의 뉴로필린-1 매개 SARS-CoV-2 감염은 파골세포 분화를 억제합니다Article Published on 2022-05-012022-09-11 Journal: Advanced Biology [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis angiotensin angiotensin-converting enzyme 2 B.1.351 bone Bone marrow bone marrow-derived macrophages calcium Clinical data Cluster Complication coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients damage dependent on differentiation Evidence expression host cell host cells Human skeleton humans identify impede in vivo Infection inhibit SARS-CoV-2 Interaction investigated knockdown macrophages marrow-derived macrophage metabolism mouse model Mouse models neuropilin Neuropilin-1 neutralization NRP1 organs osteoclast osteoclast differentiation Pathogenesis pathogenesis of SARS-CoV-2 patients phosphorus phosphorus metabolism provide receptor RNA sequencing SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significantly Single-cell RNA sequencing susceptible tissue tropism various tissue various tissues virus wild-type [DOI] 10.1002/adbi.202200007 PMC 바로가기 [Article Type] Article
The atlas of ACE2 expression in fetal and adult human hearts reveals the potential mechanism of heart-injured patients infected with SARS-CoV-2태아 및 성인 인간 심장에서 ACE2 발현의 아틀라스는 SARS-CoV-2에 감염된 심장 부상 환자의 잠재적 메커니즘을 보여줍니다Article Published on 2022-04-012022-09-11 Journal: American journal of physiology. Cell physiology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] ACE2 ACE2 expression acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Analysis analyzed angiotensin angiotensin I angiotensin I converting enzyme 2 binding calcium Calcium signaling Cardiomyopathy coronavirus dilated cardiomyopathy embryonic embryonic development embryos enzyme expressed gene expressing expression expression level expression profile fetal heart heart failure hearts host cell host cells increase infect infected with SARS-CoV-2 molecular docking Myocyte Numerous organs pathway Pathway analysis Patient potential mechanism Protein protein-protein interaction RAS RAS system regulate Renin renin-angiotensin system reveal risk of infection SARS-CoV-2 Sequencing analysis severe acute respiratory syndrome Coronavirus shown single-cell Spike protein Stage transcription profile upregulated upregulation variant spike various tissue various tissues ventricular was increased was used Wnt signaling pathway [DOI] 10.1152/ajpcell.00169.2021 PMC 바로가기 [Article Type] Article
Deep learning approach based on superpixel segmentation assisted labeling for automatic pressure ulcer diagnosis자동 압력 궤양 진단을위한 슈퍼 픽셀 세분화 보조 라벨링에 기반한 딥 러닝 접근Research Article Published on 2022-02-172022-09-10 Journal: PLoS ONE [Category] COVID19(2023년), MERS, SARS, 치료기술, [키워드] Accuracy Algorithm Algorithms applied approach Automatic best Care Clinical data Convolution COVID-19 pandemic dataset datasets deep deep learning detect Diagnosis difficulty disease domain exacerbated excluded feature FIVE healing Injury labeling Mask Medical care MONITOR Precision pressure ulcer pressure ulcers recall skin surgical tissue Traditional ulcer various tissue various tissues wound wound healing [DOI] 10.1371/journal.pone.0264139 PMC 바로가기 [Article Type] Research Article
A Previously Undiscovered Circular RNA, circTNFAIP3, and Its Role in Coronavirus ReplicationResearch Article Published on 2021-11-162022-10-29 Journal: mBio [Category] Coronavirus, [키워드] activate analyzed Apoptosis candidate Cell cells cellular response circTNFAIP3 Circular circular RNA Deltacoronavirus differentially expressed DNA virus dysregulated expressed expression facilitate function identify Infection information inhibited mechanism ncRNAs noncoding RNA promote promoted provide reducing Replication reverse transcription-PCR RNA RNA sequencing RNA virus RNA viruses role Seven significantly TNFAIP3 various tissue various tissues virus replication [DOI] 10.1128/mBio.02984-21 PMC 바로가기 [Article Type] Research Article
The Impact of ACE2 Polymorphisms on COVID-19 Disease: Susceptibility, Severity, and TherapyCOVID-19 질병에 대한 ACE2 다형성의 영향: 감수성, 중증도 및 치료Review Published on 2021-10-222022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 변종, 유전자 메커니즘, [키워드] ACE ACE2 ACE2 variant ACE2 variants acquisition acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age angiotensin Angiotensin II Angiotensin-converting enzyme angiotensin-converting enzyme 2 benefit caused Characteristics circulating combating contribute coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 disease develop disease Effect effective Epigenetic Ethnicity explain Factor functional Gender gene polymorphism help high morbidity and mortality homeostatic host genetics hrsACE2 human ACE2 human body Impact increase in measure mechanism morbidity and mortality organ organs outbreak outcome peptide peptides physiological progression putative receptor Regulation respiratory rises SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus severity severity of COVID-19 Spread Stage susceptibility the disease Transmissibility variants various tissue various tissues widespread [DOI] 10.3389/fcimb.2021.753721 PMC 바로가기 [Article Type] Review