Helmet continuous positive airway pressure versus high-flow nasal cannula in COVID-19: a pragmatic randomised clinical trial (COVID HELMET)COVID-19에서 헬멧 연속 양압기 대 고유량 비강 캐뉼러: 실용적인 무작위 임상 시험(COVID HELMET)Randomized Controlled Trial Published on 2020-12-032022-09-10 Journal: Trials [Category] MERS, SARS, 임상, 치료기술, [키워드] 1:1 90% power clinical trial COVID COVID-19 COVID-19 cohort COVID-19 epidemic CPAP detect End-Expiratory Pressure Evidence feasible Helmet CPAP HFNC High-flow nasal cannula hypothesise hypoxaemia implication International intubation Invasive mechanical ventilation investigator investigator-initiated low-flow oxygen therapy Mann-Whitney U test nasal nasal cannula oxygen Oxygen therapy Patient patient recruitment PEEP positive airway pressure Positive end-expiratory pressure Pragmatic Primary outcome randomised Randomised controlled trial protocol Randomised trial reduce required Sample size significance level survival treated Trial registration ventilator free day ventilator free days Ventilator-free days VFD with COVID-19 [DOI] 10.1186/s13063-020-04863-5 PMC 바로가기 [Article Type] Randomized Controlled Trial
A prospective, randomised, double blind placebo-controlled trial to evaluate the efficacy and safety of tocilizumab in patients with severe COVID-19 pneumonia (TOC-COVID): A structured summary of a study protocol for a randomised controlled trialLetter Published on 2020-06-032022-10-29 Journal: Trials [Category] Coronavirus, SARS, [키워드] 1:1 48 hour Admission allergic reaction anticipated application AST/ALT Bacterial infection Bacterial infections blinded block Breast feeding clinical clinical trial Combination concealed conducted Contraception Control COVID-19 COVID-19 patient criteria defined dependent on Desirable diagnostic Diaphragm dissemination dose double blind ECMO Efficacy Efficacy and safety element Endpoint evaluate extracorporeal membrane oxygenation failure female Germany Hospital stay Hydroxychloroquine IL-6-Rezeptor blockade Immunosuppression immunosuppressive therapy IMV independent Inflammation ingredient Injury Inpatient intensive care units interfere Invasive mechanical ventilation investigator investigators less life lung failure mechanical ventilation methotrexate NaCl NIV non-invasive ventilation number objective outcome parallel group parameters participant Participation Pathogenesis Patient patients PCT performed placebo-controlled trial Pneumonia polymerase chain positive Prednisolone produced progression proof protocol Pulmonary function pulmonary inflammation Quality of life randomisation randomised randomised controlled trial recruited reduce Registered respiratory Safe Sample size SARS-CoV-2 SARS-CoV2 SARS-CoV2 infection SAS severe COVID-19 Severe COVID-19 pneumonia Simultaneous single dose status stratified Study protocol sulfasalazine System the patient therapy Tocilizumab Treatment Trial trials Tuberculosis ULN unit Ventilation ventilator ventilator free day ventilator free days VFD Viral hepatitis website [DOI] 10.1186/s13063-020-04447-3 PMC 바로가기 [Article Type] Letter