Semisynthetic teicoplanin derivatives with dual antimicrobial activity against SARS-CoV-2 and multiresistant bacteriaArticle Published on 2022-09-262022-11-15 Journal: Scientific Reports [Category] SARS, 치료제, [키워드] active against Affect Antibiotics antimicrobial Antiviral approved Bacteria Bacterial cells Co-infection Compound conjugate coronavirus derivative drug drugs effective Efficacy Endemic endosomal entry enzyme HCoV-229E human Calu-3 cell hydrophobic infected with SARS-CoV-2 inhibiting inhibition assay inhibitor membrane modifications Prevent Prognosis risk RNA virus SARS-CoV-2 SARS-CoV-2 replication Seven shown VeroE6 cells [DOI] 10.1038/s41598-022-20182-y PMC 바로가기
Neutralization of Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant by Sera From BNT162b2 or CoronaVac Vaccine RecipientsBNT162b2 또는 CoronaVac 백신 수혜자의 혈청에 의한 중증 급성 호흡기 증후군 코로나바이러스 2 오미크론 변이체의 중화Article Published on 2022-08-242022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 변종, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antibody titer Antibody titers Beta Beta variant beta variants BNT162b2 CoronaVac coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccine Delta variants detectable Effectiveness elicited evade genome sequence geometric geometric mean GISAID database GMT GMTs Health Organization isolate Lineage Live virus microneutralization Mutation Nanopore nanopore sequencing neutralization Neutralizing Neutralizing antibodies neutralizing antibody Neutralizing antibody titer no significant difference not affect of BNT162b2 omicron Omicron variant Patient recipient recipients respiratory risk Risk assessment SARS-CoV-2 Sequencing sera severe acute respiratory syndrome Coronavirus significant difference significantly lower spike mutation strain Strains susceptibility TMPRSS2 Vaccine Vaccines variant variant of concern VeroE6 cells virus was determined whole genome sequence World Health Organization [DOI] 10.1093/cid/ciab1041 PMC 바로가기 [Article Type] Article
Cross-Neutralization of SARS-CoV-2-Specific Antibodies in Convalescent and Immunized Human Sera against the Bat and Pangolin Coronaviruses박쥐 및 천산갑 코로나바이러스에 대한 회복기 및 면역화된 인간 혈청에서 SARS-CoV-2-특이적 항체의 교차 중화Article Published on 2022-08-162022-09-12 Journal: Viruses [Category] SARS, 진단, [키워드] ACE2 analyzed appear bat bat coronavirus binding Cell cell-cell fusion chimeric chimeric proteins contribute coronavirus COVID-19 COVID-19 patient cross-neutralize highest Human human ACE2 receptor human host immunized inactivated induce less neutralization neutralization activity neutralized Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody overexpressing pandemic pangolin pangolin coronavirus pangolins pre-existing immunity promote Protein pseudo-virus pseudo-virus. RaTG13 RBD replaced sarbecovirus SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine serum sample significantly significantly higher spike the RBD the receptor-binding domain thought transmitted vaccination VeroE6 cells while widespread [DOI] 10.3390/v14081793 PMC 바로가기 [Article Type] Article
Clinical grade ACE2 as a universal agent to block SARS-CoV-2 variantsSARS-CoV-2 변종을 차단하는 범용 약제로서의 임상 등급 ACE2Article Published on 2022-08-082022-09-11 Journal: EMBO Molecular Medicine [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] ACE2 Alpha analyzed Beta binding affinity caused clinical clinical trial COVID-19 Delta develop Efficacy epithelial cell epithelial cells Gamma human lung human lung epithelial cells independent Infection inhibit inhibited neutralized neutralizing antibody omicron Phase 2 principle proof reduced SARS-CoV-2 isolates SARS-CoV-2 variant SARS-CoV-2 variants several variant several variants soluble ACE2 strain tested therapeutic Therapeutic strategies therapeutic strategy These data Treatment Vaccine variants variants of concern VeroE6 cell VeroE6 cells VoC [DOI] 10.15252/emmm.202115230 PMC 바로가기 [Article Type] Article
A Study of Drug Repurposing to Identify SARS-CoV-2 Main Protease (3CLpro) InhibitorsSARS-CoV-2 주요 프로테아제(3CLpro) 억제제 식별을 위한 약물 용도 변경 연구Article Published on 2022-06-092022-09-11 Journal: International Journal of Molecular Sciences [Category] Coronavirus, COVID19(2023년), SARS, 신약개발, 치료제, [키워드] 3CL 3CLpro acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Administered Antiviral antiviral activity artificial artificial intelligence caused Cell Combination Compound compounds coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cynarine cytotoxicity docking drug Drug repurposing eravacycline FRET in silico in vitro infected with SARS-CoV-2 inhibitory activity inhibitory compounds intelligence MPro outbreak phase prexasertib protease repurposing safety profile SARS-CoV-2 SARS-CoV-2 3CL protease SARS-CoV-2 main protease selected severe acute respiratory syndrome Coronavirus tested the disease Treatment trials Vaccine VeroE6 cell VeroE6 cells were used [DOI] 10.3390/ijms23126468 PMC 바로가기 [Article Type] Article
Establishment of a stable SARS-CoV-2 replicon system for application in high-throughput screening고처리량 스크리닝 적용을 위한 안정적인 SARS-CoV-2 레플리콘 시스템 구축Article Published on 2022-03-012022-09-11 Journal: Antiviral Research [Category] SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Antiviral Antiviral effect antiviral effects Bacterial bacterial artificial chromosome biosafety level Biosafety Level 3 BSL2 BSL3 camostat Cell cell line cell lines cells chromosome compounds condition conditions coronavirus COVID-19 examined exhibited Favipiravir gene encoding In vitro infection inhibited interferon level 3 luciferase luciferase activity molnupiravir Neomycin Novel coronavirus Particles powerful tool produced RdRP RdRp inhibitor Remdesivir Renilla Renilla luciferase replicon reported RNA SARS-coronavirus SARS-coronavirus-2 SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 sgRNA sgRNAs stable cell stable cell line suppressed the SARS-CoV-2 transient transfection transiently transfected Treatment VeroE6 cells Viral proteins viral replication [DOI] 10.1016/j.antiviral.2022.105268 PMC 바로가기 [Article Type] Article
Biodegradable Nanohybrid Materials as Candidates for Self-Sanitizing Filters Aimed at Protection from SARS-CoV-2 in Public Areas공공 장소에서 SARS-CoV-2로부터 보호하기 위한 자체 소독 필터의 후보로서의 생분해성 나노하이브리드 재료Article Published on 2022-02-162022-09-10 Journal: Molecules [Category] COVID19(2023년), MERS, SARS, 치료제, [키워드] anti-SARS-CoV-2 antiviral activity antiviral coating Antiviral effect Area can not candidate coating Concentration condition copper COVID-19 pandemic cultivation deposition effective evaluated exhibited exhibiting facemask facemasks Filter filtration highest implantation internal Ion ions material methodology Nanofiber nanofibers opens plasma positive problem PROTECT protection Public raised Rate released return SARS-CoV-2 significantly higher silver transmitted VeroE6 cell VeroE6 cells viability virus viruses XPS [DOI] 10.3390/molecules27041333 PMC 바로가기 [Article Type] Article
Viral isolation analysis of SARS-CoV-2 from clinical specimens of COVID-19 patientsCOVID-19 환자의 임상 표본에서 SARS-CoV-2의 바이러스 분리 분석Article Published on 2022-02-012022-09-11 Journal: Journal of infection and chemotherapy : official j [Category] COVID19(2023년), SARS, 치료기술, [키워드] Analysis Cell Chain Reaction clinical Clinical specimens Contamination correlation COVID-19 COVID-19 patient COVID-19 patients Ct value Ct values cultured cells cycle Cytopathic effect detectable diagnosis of COVID-19 examined Genetic testing herpes simplex herpes simplex virus herpes simplex virus type 1 Infectious virus infectious viruses investigated Isolation less Lower no significant difference PCR test polymerase chain polymerase chain reaction reverse transcriptase rRT-PCR rRT-PCR test SARS-CoV-2 SARS-CoV-2 genome specimen the mean threshold Threshold cycle (Ct) value TMPRSS2 TMPRSS2 cells transcriptase VeroE6 cell VeroE6 cells VeroE6/TMPRSS2 virus virus isolation [DOI] 10.1016/j.jiac.2021.10.028 PMC 바로가기 [Article Type] Article
Synthesis and antiviral activity of fatty acyl conjugates of remdesivir against severe acute respiratory syndrome coronavirus 2 and Ebola virus중증 급성 호흡기 증후군 코로나바이러스 2 및 에볼라 바이러스에 대한 렘데시비르의 지방 아실 접합체의 합성 및 항바이러스 활성Article Published on 2021-12-152022-09-11 Journal: European journal of medicinal chemistry [Category] SARS, 신약개발, 치료제, [키워드] A significant reduction acute respiratory syndrome antiviral activities antiviral activity antiviral agent Antiviral agents Calu3 CaLu3 cells characterization comparable Compound conjugate Conjugates coronavirus derivative derivatives Ebola Ebola virus EBOV Effectiveness exhibited fatty Fatty acid fatty acids Fatty acyl-RDV conjugates half-life Human plasma IMPROVE in viral in vitro less mono physical purification RDV reduction in remained Remdesivir Replication RNA synthesis SAR SAR-CoV-2 SARS-CoV-2 selected shown Structure-activity relationships (SAR). synthesis these compound these compounds Transcription VeroE6 cells Viral RNA viral RNA synthesis [DOI] 10.1016/j.ejmech.2021.113862 PMC 바로가기 [Article Type] Article
Efficacy of Ion-Channel Inhibitors Amantadine, Memantine and Rimantadine for the Treatment of SARS-CoV-2 In Vitro시험 관내 SARS-COV-2의 치료를위한 이온 채널 억제제 아만타딘, 메만 틴 및 리만타딘의 효능Brief Report Published on 2021-10-152022-09-10 Journal: Viruses [Category] SARS, 신약개발, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adamantane amantadine antagonistic Antiviral barrier to escape cells combination treatment coronavirus COVID-19 Drug repurposing effective Efficacy followed by hepatitis C virus p7 inhibitor hepatoma highest Huh7.5 in vitro inhibitor inhibitors ion-channel inhibitor lung carcinoma Memantine Remdesivir respiratory Rimantadine SARS-CoV-2 selectivity index severe acute respiratory syndrome Coronavirus Treatment VeroE6 cells Viral viral entry viral escape [DOI] 10.3390/v13102082 PMC 바로가기 [Article Type] Brief Report