Elevated Myl9 reflects the Myl9-containing microthrombi in SARS-CoV-2-induced lung exudative vasculitis and predicts COVID-19 severity상승된 Myl9는 SARS-CoV-2 유발 폐삼출성 혈관염에서 Myl9 함유 미세혈전을 반영하고 COVID-19 중증도를 예측합니다Article Published on 2022-08-162022-09-12 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] accompanied accumulated activation of platelets acute respiratory syndrome Analysis Autopsy Clinical severity coronavirus coronavirus disease correlated COVID-19 COVID-19 patient COVID-19 severity exudative vasculitis fatal disease histological immune dysregulation immunothrombosis lung marker Microscopy microthrombi monocyte mononuclear cell Mortality nonconventional monocytes Pathogenesis pathology Peripheral blood plasma plasma Myl9. predict provide reflect SARS-CoV-2 severity Single-cell RNA sequencing the disease treatment for COVID-19 Vascular Vasculitis vessels X-ray spectroscopy [DOI] 10.1073/pnas.2203437119 PMC 바로가기 [Article Type] Article
Melatonin drugs inhibit SARS-CoV-2 entry into the brain and virus-induced damage of cerebral small vesselsArticle Published on 2022-06-132022-10-04 Journal: Cellular and Molecular Life Sciences [Category] COVID19(2023년), SARS, 신약개발, [키워드] ACE2 acute phase Analysis binding Brain Brain infection Cell clinical symptom clinically complex COVID-19 disease drug Drug repurposing drugs Endothelial cell entry receptor Human human Angiotensin-converting enzyme Immune cell infiltration IMPROVE Infection infection with SARS-CoV-2 Inflammation Inflammatory inhibit SARS-CoV-2 involved K18-hACE2 K18-hACE2 mice long-lasting melatonin Neuro-vasculature Neurological symptom Neurological symptoms Perspective Prevent prevented prevention reducing SARS-CoV-2 SARS-CoV-2 entry small vessel survival symptoms of COVID-19 the disease therapeutic Treatment triggered vessels [DOI] 10.1007/s00018-022-04390-3 PMC 바로가기 [Article Type] Article
Lung Spatial Profiling Reveals a T Cell Signature in COPD Patients with Fatal SARS-CoV-2 Infection폐 공간 프로파일링은 치명적인 SARS-CoV-2 감염이 있는 COPD 환자의 T 세포 서명을 나타냅니다Article Published on 2022-06-072022-09-11 Journal: Cells [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] airways Antigen CD4 CD45 CD45RO Cell characterized chronic obstructive chronic obstructive pulmonary disease chronic obstructive pulmonary disease (COPD) chronic obstructive pulmonary disease (COPD). COPD COVID-19 COVID-19 infection death died downregulation expression Gene Expression immune microenvironment immune response invasive lung Lung disease Lung diseases lung parenchyma memory memory T memory T cell obstructive pulmonary disease parenchyma Patient patients priming Profiling Protein proteomic pulmonary disease receptor ROI ROIs SARS-CoV-2 SARS-CoV-2 disease SARS-CoV-2 disease 2019 SARS-CoV-2 entry SARS-COV-2 infection sick signature significant enrichment Smokers Still structural gene T cell T cell response T cells T-lymphocyte T-lymphocytes transcriptomic underlie vessel vessels with COVID-19 [DOI] 10.3390/cells11121864 PMC 바로가기 [Article Type] Article
Inactivated COVID-19 vaccine induced acute stroke-like focal neurologic symptoms: a case series비활성화된 코로나19 백신 유발 급성 뇌졸중 유사 국소 신경 증상: 사례 시리즈Article Published on 2022-06-072022-09-11 Journal: BMC Neurology [Category] COVID19(2023년), SARS, 치료기술, [키워드] abnormality age benefit Brain Brain imaging brain infarction Case series case sery clinical Clinical characteristics collected COVID-19 COVID-19 pandemic COVID-19 vaccination COVID-19 vaccine detect deviation enrolled Evidence evidence of female Follow-up followed by had no headache inactivated Inactivated COVID-19 vaccine individual Infarction investigated laboratory investigation median Most patients motor weakness Neuroimaging neurologic Neurological complication neurological sign Neurological symptom Neurological symptoms no evidence of numbness outcome parenchymal pathophysiology Patient patients receiving Recurrent sensory deficit Side effects Stroke-like symptoms. subject Symptom Symptoms tongue tongue deviation Transient vaccination Vascular vessels was done weakness [DOI] 10.1186/s12883-022-02739-6 PMC 바로가기 [Article Type] Article
Pulmonary vascular inflammation with fatal coronavirus disease 2019 (COVID-19): possible role for the NLRP3 inflammasomeResearch Published on 2022-02-102022-10-28 Journal: Respiratory Research [Category] COVID-19, MERS, [키워드] accompany Activation acute respiratory disease affected appear ARDS caspase causes changes in component coronavirus disease COVID-19 disease distress expression H&E histological histopathological features hyperinflammation Inflammation Injury lung Lung inflammation Lungs Mechanical ventilation mechanical ventilation microthrombi Microthrombosis NLRP3 NLRP3 inflammasome Non-COVID-19 not different outcome pathway pulmonary response Result SARS-COV-2 infection shown subject subjects supplementary material syndrome thrombosis Treatment Vascular Vascular change Vascular endothelium vascular inflammation vessel wall vessels [DOI] 10.1186/s12931-022-01944-8 PMC 바로가기 [Article Type] Research
The Role of Von Willebrand Factor in the Pathogenesis of Pulmonary Vascular Thrombosis in COVID-19Article Published on 2022-01-212022-10-28 Journal: Viruses [Category] COVID-19, [키워드] ARDS Bacterial correlation COVID-19 demonstrated died disease disease severity Duration endothelial Endothelium Factor histological immunostaining independent independent predictor intensity lung Mortality nonsurvivor Pathogenesis Patient patients with COVID-19 performed plasma Pneumonia pulmonary Pulmonary embolism reported role SARS-CoV-2 significant increase significantly more staining intensity the disease the patient thrombosis thrombotic complication Thrombotic complications thrombus formation Vascular endothelium Ventilation venular vessels von Willebrand factor vWF [DOI] 10.3390/v14020211 PMC 바로가기 [Article Type] Article
Cardiovascular System during SARS-CoV-2 InfectionReview Published on 2022-01-212022-10-30 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] Acute cardiac injury Arrhythmias Biomarkers Cardiac complications cardiac injury cardiological cardiovascular cardiovascular complication cardiovascular disease Comorbidity complications conducted Coronavirus disease 2019 COVID-19 death rate deteriorate diabetes diagnosed disease hypertension independent risk factor infected patient Infection Injury library myocardial injury occur other organs outcome Oxford Patient patients with COVID-19 patients with SARS-CoV-2 Prognosis Research Respiratory system SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus System troponin UpToDate vessels [DOI] 10.3390/ijerph19031184 PMC 바로가기 [Article Type] Review
3D virtual histopathology of cardiac tissue from Covid-19 patients based on phase-contrast X-ray tomographyResearch Article Published on 2021-12-212022-10-31 Journal: eLife [Category] COVID-19, SARS, [키워드] alteration Analysis analyzed annotations automated cardiac tissue concerning controls COVID-19 dataset deep learning distribution elevated High-resolution histopathological Histopathology Human Influenza Intussusceptive angiogenesis Laboratory measure Microscopy myocarditis Occurrence pathological pathological change Patient progression quantified Radiation Tensor tissue tomography Variation Vascular vessels virus X-ray X-ray tomography [DOI] 10.7554/eLife.71359 PMC 바로가기 [Article Type] Research Article
Interactions of adenoviruses with platelets and coagulation and the vaccine-induced immune thrombotic thrombocytopenia syndrome혈소판 및 응고와 아데노바이러스의 상호작용 및 백신 유발 면역 혈전성 혈소판 감소증 증후군Review Published on 2021-12-012022-09-11 Journal: Haematologica [Category] SARS, 치료기술, [키워드] adenoviral vector adenoviral vectors Adenovirus adenovirus-based affected age antibody AstraZeneca benefit Blood coagulation Characteristics Clinical data Coagulation Course COVID-19 pandemic Disseminated intravascular coagulation Economy Endothelium epidemiological studies Evidence Evolution fertile global health Health hypothese identify immune immunological reaction Infection Interaction intravascular coagulation janssen mechanism patients Platelet Platelets Prognostic factor Prognostic factors proportion reported Research subject syndrome thrombocytopenia thrombotic thrombotic complication thrombotic event triggering unique vaccination Vaccine Vaccines venous vessels women [DOI] 10.3324/haematol.2021.279289 PMC 바로가기 [Article Type] Review
Case Reports: Bronchial Mucosal Vasculature Is Also Involved in the Acute Vascular Distress Syndrome of COVID-19Medicine Published on 2021-11-302022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] acute respiratory syndrome addressed AVDS BAL bronchial Bronchoalveolar lavage bronchovideoscopy Case report contributes coronavirus coronavirus disease COVID-19 COVID-19 disease COVID-19 pandemic description dry cough Dyspnoea Fever Ground glass opacity highlight induce intrapulmonary Intrapulmonary shunt knowledge mucosa NBI (narrow band imaging) patients patients hospitalized performed Pharyngeal swab Pneumonia pulmonary blood flow repeated RT-PCR SARS-CoV-2 Shunt Symptom target Thoracic two patients Vascular vasculature vessel vessels viral disease [DOI] 10.3389/fmed.2021.710992 PMC 바로가기 [Article Type] Medicine