Recombinant Rod Domain of Vimentin Reduces SARS-CoV-2 Viral Replication by Blocking Spike Protein–ACE2 InteractionsArticle Published on 2024-02-202024-09-05 Journal: International Journal of Molecular Sciences [Category] update2024, [키워드] acute lung injury COVID-19 SARS-CoV-2 vimentin [DOI] 10.3390/ijms25052477 PMC 바로가기 [Article Type] Article
The Function behind the Relation between Lipid Metabolism and Vimentin on H9N2 Subtype AIV ReplicationArticle Published on 2022-08-182023-06-22 Journal: Viruses [Category] 조류인플루엔자, [키워드] AMPK cholesterol H9N2 subtype AIV HMGCR Lipid rafts vimentin [DOI] 10.3390/v14081814 PMC 바로가기
Cell surface detection of vimentin, ACE2 and SARS-CoV-2 Spike proteins reveals selective colocalization at primary ciliavimentin, ACE2 및 SARS-CoV-2 스파이크 단백질의 세포 표면 검출은 일차 섬모에서 선택적 공동 국소화를 나타냅니다Article Published on 2022-04-292022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료기술, [키워드] ACE2 acetylated tubulin Arl13b binding Cell cell surface cell types cells cellular receptor cellular receptors ciliated cytoplasm docking Extracellular facilitate filament protein immunoreactivity Incubation Interaction Intermediate filament marker moderate occur Particle plasma membrane platform positive Protein receptor reported reveal S1 subunit SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein selective spike Spike protein Spike proteins structures tubulin vimentin viral invasion virus [DOI] 10.1038/s41598-022-11248-y PMC 바로가기 [Article Type] Article
Extracellular vimentin is an attachment factor that facilitates SARS-CoV-2 entry into human endothelial cells423 Published on 2022-01-252022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, COVID19(2023년), SARS, [키워드] A549 cell ACE2 Analysis angiotensin-converting enzyme 2 antibody bind binding blocked Cell cellular component Complication contribute CR3022 Endothelial cell endothelial cells Entry mechanism entry receptor enzyme epitope expressed expressing Extracellular facilitate filament protein HEK-293 cell HEK-293 cells host cell Human implication in viral inhibited Interaction knockdown lung neutralized Pathogenesis pathogenesis of COVID-19 performed Protein provide pseudotyped Pseudotyped virus purified RBD Receptor binding domain recognize reduced S-protein S-RBD SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2-S Significance significantly the SARS-CoV-2 Transmission Vaccines Vascular VIM vimentin viral entry virus with COVID-19 [DOI] 10.1073/pnas.2113874119 PMC 바로가기 [Article Type] 423
HBV HBx-Downregulated lncRNA LINC01010 Attenuates Cell Proliferation by Interacting with VimentinArticle Published on 2021-11-192023-06-03 Journal: International Journal of Molecular Sciences [Category] B형 간염, [키워드] LINC01010 cell proliferation HBV vimentin [DOI] 10.3390/ijms222212497 PMC 바로가기 [Article Type] Article
Spread of vimentin-immunoreactive cells within the plaque-like lesion in the spinal anterior horn of a patient with post-poliomyelitis syndromearticle Published on 2021-10-312024-09-01 Journal: Neuropathology [Category] 폴리오, [키워드] Astrocyte plaque-like lesion post-poliomyelitis syndrome spinal cord vimentin [Article Type] article
A Vimentin-Targeting Oral Compound with Host-Directed Antiviral and Anti-Inflammatory Actions Addresses Multiple Features of COVID-19 and Related Diseases숙주 지향적 항바이러스 및 항염 작용이 있는 Vimentin 표적 경구 화합물은 COVID-19 및 관련 질병의 여러 특징을 다룹니다Research Article Published on 2021-10-122022-09-10 Journal: mBio [Category] MERS, 변종, 치료제, [키워드] Action affected Anti-inflammation anti-inflammatory actions Antiviral Bleomycin cellular cellular processe complications Compound COVID-19 cultured cells damage disease symptom Diseases drug effective Efficacy endosomal trafficking Factor fibrosis filaments focus function host immune responses host-directed antiviral human ACE2 hyperinflammation identify immune responses Infection inhibited late-stage disease lung damage Lung injury macrophages mechanism mice Multiple oral outcome overactive pathogen pathogen clearance Patient physical physical properties Protein RATs reduced reducing regulatory T cells Safe SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 virus small molecule Spike protein T cells targets the SARS-CoV-2 the SARS-CoV-2 virus therapeutic agent therapeutic agents therapeutic potential treating COVID-19 triggered unique vimentin Viral Viral load Viral mutations [DOI] 10.1128/mBio.02542-21 PMC 바로가기 [Article Type] Research Article
Combination Treatment with the Vimentin-Targeting Antibody hzVSF and Tenofovir Suppresses Woodchuck Hepatitis Virus Infection in WoodchucksArticle Published on 2021-09-052023-06-03 Journal: Cells [Category] B형 간염, Fulltext, [키워드] antiviral efficacy Chronic Hepatitis B Entry inhibitor Hepatitis B virus humanized antibody hzVSF Liver inflammation Safety Tenofovir alafenamide fumarate vimentin Woodchuck [DOI] 10.3390/cells10092321 PMC 바로가기 [Article Type] Article
Role of Extracellular Vimentin in Cancer-Cell Functionality and Its Influence on Cell Monolayer Permeability Changes Induced by SARS-CoV-2 Receptor Binding DomainArticle Published on 2021-07-122022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] activated macrophages Activation activation pathway addition Alter angiotensin-converting enzyme 2 Astrocyte Bacterial bind binding binding domain Cancer Cancer cells cancer progression Cell Cell migration cells cellular change cytoskeletal domain Effect ENhance Extracellular extracellular space extracellular vimentin functional functions growth IGF-1 IGF-1 receptor induced Inflammation influence investigated involved MCF-7 Migration modulate modulation monolayer monolayers neutrophil infiltration overexpressed permeability physiological conditions proliferation promote Protein receptor Receptor binding domain reduced reduction role SARS-CoV-2 SARS-CoV-2 infections SARS-CoV-2 receptor SARS-COV-2 receptor binding domain SARS-CoV-2 spike protein secreted shown Spike protein Support surface the SARS-CoV-2 Treatment vimentin viral infection while [DOI] 10.3390/ijms22147469 PMC 바로가기 [Article Type] Article
Mechanical and Non-Mechanical Functions of Filamentous and Non-Filamentous VimentinReview Published on 2020-11-012023-07-11 Journal: Bioessays [Category] SARS, [키워드] cytoskeleton intermediate filaments nucleus Pathogenesis vimentin [DOI] 10.1002/bies.202000078 PMC 바로가기 [Article Type] Review