Evolutionary deletions within the SARS-CoV-2 genome as signature trends for virus fitness and adaptationMinireview Published on 2024-01-132024-09-05 Journal: Journal of virology [Category] update2024, [키워드] deletions evolutionary mechanisms SARS-CoV-2 structural mutations viral adaptation [DOI] 10.1128/jvi.01404-23 PMC 바로가기 [Article Type] Minireview
Hotspot residues and resistance mutations in the nirmatrelvir-binding site of SARS-CoV-2 main protease: Design, identification, and correlation with globally circulating viral genomesArticle Published on 2022-11-122022-11-15 Journal: Biochemical and Biophysical Research Communication [Category] SARS, 변종, 치료제, [키워드] acute respiratory syndrome Adaptability Antiviral approved circulating coronavirus correlation COVID-19 cases COVID-19 pandemic develop drug resistance FDA highest hotspot intracellular protein Like M pro main protease Mild-to-moderate mutant Mutation mutations Nirmatrelvir offer omicron predicted Probability protease Protein design reported residue residues resistance resistance mutations robust SARS-CoV-2 SARS-CoV-2 lineage signature Signatures of adaptation. Surveillance unique variant Variation variations viral adaptation viral genome viruses [DOI] 10.1016/j.bbrc.2022.09.010 PMC 바로가기
Structural basis for mouse receptor recognition by SARS-CoV-2 omicron variantArticle Published on 2022-11-012022-11-16 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 acute respiratory syndrome Angiotensin-converting enzyme coronavirus COVID-19 domain Effect ENhance human ACE2 human Angiotensin-converting enzyme humans infect investigated mouse angiotensin-converting enzyme 2 Mutation Mutational hotspots N501Y Omicron variant question raised RBD receptor Receptor-binding domain (RBD) SARS-CoV-2 Spread the RBD viral adaptation X-ray X-ray crystallography [DOI] 10.1073/pnas.2206509119 PMC 바로가기
Mutational induction in SARS-CoV-2 major lineages by experimental exposure to neutralising sera중화 혈청에 대한 실험적 노출에 의한 SARS-CoV-2 주요 계통의 돌연변이 유도Article Published on 2022-07-212022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] acquisition addition antibody characterisation escape mutation Evolution Evolution of SARS-CoV-2 human population immune evasion immune response Interaction Lineage Mutagenesis neutralisation neutralising neutralising antibody Neutralizing antibody response offer Perspective promoted required responsible SARS-CoV-2 sera species structural protein structural proteins target Viral viral adaptation viral variant [DOI] 10.1038/s41598-022-16533-4 PMC 바로가기 [Article Type] Article
Ex vivo and in vivo suppression of SARS-CoV-2 with combinatorial AAV/RNAi expression vectors조합 AAV/RNAi 발현 벡터를 사용한 SARS-CoV-2의 생체외 및 생체내 억제Article Published on 2022-05-042022-09-11 Journal: Molecular therapy : the journal of the American So [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] AAV acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition adeno-associated virus Antiviral Antiviral agents antiviral RNAi Cell clinically cocktail complement coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 disease symptom effective escape mutant escape mutants experiment expression vector flexible Genetic global effort Gut hACE2 in vivo infected cell infected cells intestinal cells intranasal mice mutational escape. N gene N genes organoids pandemic prevented RdRP RNA RNAi SARS virus SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RdRp SARS-CoV-2 strains severe acute respiratory syndrome Coronavirus suppressed the SARS-CoV-2 therapeutic translation triggers Vaccine vector vectors viral adaptation Viral load viral loads virus wild-type [DOI] 10.1016/j.ymthe.2022.01.024 PMC 바로가기 [Article Type] Article
Unsupervised explainable AI for molecular evolutionary study of forty thousand SARS-CoV-2 genomesResearch Published on 2022-03-102022-10-28 Journal: BMC Microbiology [Category] COVID-19, MERS, SARS, [키워드] applied big data changes clade clades Cluster Clustering complement concerning COVID-19 division feature FIVE Genome genome sequence genomic region genomic sequence hidden information knowledge modifications molecular oligonucleotide PCR primer Phylogenetic provided public health responsible Result reveal RNA SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes sequence supplementary material Therapeutic oligonucleotide viral adaptation virus while zoonotic virus [DOI] 10.1186/s12866-022-02484-3 PMC 바로가기 [Article Type] Research
Targeted vaccination and the speed of SARS-CoV-2 adaptation표적 백신 접종과 SARS-CoV-2 적응 속도Article Published on 2022-01-182022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptation Analysis consequence coronavirus country COVID-19 cumulative deaths determine effective epidemiological epidemiologically Evolutionary epidemiology expected faster Frequency Host increase individual involved Older proportion pros question raise reduce required SARS-CoV-2 second dose severe acute respiratory syndrome Coronavirus single dose speed Spread target the disease vaccinate vaccination Vaccination strategy Vaccine variant viral adaptation [DOI] 10.1073/pnas.2110666119 PMC 바로가기 [Article Type] Article
Evolution of enhanced innate immune evasion by SARS-CoV-2SARS-CoV-2에 의한 강화된 타고난 면역 회피의 진화Article Published on 2021-12-232022-09-10 Journal: Nature [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료법, [키워드] Activation adaptation airway airway epithelial cell airway epithelial cells Alpha Alpha variant antagonists assays association B.1.1.7 changes in characterization coding region contribute Delta Duration of infection effective effort ENhance epithelial cells expression first-wave Human human-to-human transmission immune responses increase increase in innate immune innate immune response innate immune responses Interaction isolate isolates lead likelihood MAVS mitochondrial Mutation nucleocapsid protein observation omicron ORF6 Orf9b Phosphoproteomics Phosphorylation Protein protein level protein levels Proteins proteomics regulated regulatory region Replication required RNA RNA sequencing SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Spike protein suppress suppresse suppressed Systems biology the spike protein Transmission upregulation variant variants variants of concern Viral viral adaptation viral replication [DOI] 10.1038/s41586-021-04352-y PMC 바로가기 [Article Type] Article
Insight into the emerging role of SARS-CoV-2 nonstructural and accessory proteins in modulation of multiple mechanisms of host innate defense숙주 선천적 방어의 다중 메커니즘의 조절에서 SARS-COV-2 비 구조 및 보조 단백질의 새로운 역할에 대한 통찰력Review Published on 2021-10-012022-09-01 Journal: Bosnian Journal of Basic Medical Sciences [Category] 진단, [키워드] accessory protein accessory proteins Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Antigen presentation Apoptosis array caused complex coronavirus coronavirus disease Coronavirus disease-19 COVID-19 Defense disease severity disrupting effector molecules Elimination ENhance favor Frame Health Host host immune system IFN-I IFN-I signaling immune evasion immune response immunomodulators Infection Infectious disease Inflammatory mediators insight interferon mediators modulate modulation molecular multiple mechanism nonstructural protein nonstructural proteins Nsps ORFs pathogenic pathway persistence proinflammatory respiratory SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus Signaling Therapies therapy type I interferon Vaccine Viral viral adaptation virus [DOI] 10.17305/bjbms.2020.5543 PMC 바로가기 [Article Type] Review
Insight into the emerging role of SARS-CoV-2 nonstructural and accessory proteins in modulation of multiple mechanisms of host innate defenseReview Published on 2021-10-012022-10-27 Journal: Bosnian Journal of Basic Medical Sciences [Category] COVID-19, [키워드] accessory protein accessory proteins Activation acute respiratory syndrome addition Antigen presentation Apoptosis caused complex coronavirus COVID-19 Defense disease severity disrupting effector molecules ENhance favor Frame Health Host host immune system IFN-I IFN-I signaling immune evasion immune response immunomodulators Infection Infectious disease Inflammatory mediators insight interferon modulate modulation molecular multiple mechanism nonstructural protein nonstructural proteins ORFs pathogenic pathway persistence proinflammatory SARS-CoV-2 SARS-COV-2 infection Signaling Therapies therapy type I interferon Vaccine viral adaptation virus [DOI] 10.17305/bjbms.2020.5543 PMC 바로가기 [Article Type] Review