SARS-CoV-2 omicron BA.2.87.1 exhibits higher susceptibility to serum neutralization than EG.5.1 and JN.1Emerging and Re-Emerging Coronaviruses Published on 2024-05-232024-09-05 Journal: Emerging Microbes & Infections [Category] update2024, [키워드] Antibody evasion BA.2.87.1 COVID-19 EG.5.1 JN.1 polyclonal sera; mRNA vaccines receptor engagement SARS-CoV-2 viral infectivity [DOI] 10.1080/22221751.2024.2359004 PMC 바로가기 [Article Type] Emerging and Re-Emerging Coronaviruses
Quercetin: A promising drug candidate against the potential SARS-CoV-2-Spike mutants with high viral infectivityShort Communication Published on 2023-10-172024-09-05 Journal: Computational and Structural Biotechnology Journal [Category] update2024, [키워드] COVID-19 quercetin SARS-CoV-2 spike mutants viral infectivity [DOI] 10.1016/j.csbj.2023.10.029 PMC 바로가기 [Article Type] Short Communication
Overview of immunological & virological factors driving the evolution & global spread of SARS-CoV-2 variantsPractice: Review Article Published on 2023-09-162024-09-05 Journal: The Indian journal of medical research [Category] update2024, [키워드] COVID-19 immune evasion natural selection – SARS-CoV-2 viral infectivity Viral mutations viral transmissibility viral variants of concern [DOI] 10.4103/ijmr.ijmr_2591_22 PMC 바로가기 [Article Type] Practice: Review Article
High-throughput screening of mutations affecting SARS-CoV-2 spike functionsSpotlight Published on 2023-03-292024-09-05 Journal: Trends in immunology [Category] update2024, [키워드] deep mutational scanning immune evasion SARS-CoV-2 Spike protein viral infectivity [DOI] 10.1016/j.it.2023.03.010 PMC 바로가기 [Article Type] Spotlight
Role of cholesterol-recognition motifs in the infectivity of SARS-CoV-2 variantsArticle Published on 2023-02-012023-07-11 Journal: Colloids and surfaces. B, Biointerfaces [Category] COVID19(2023년), [키워드] Cell-surface phenomena cholesterol Cholesterol recognition motifs Cholesterol-protein interactions fusion proteins viral infectivity [DOI] 10.1016/j.colsurfb.2022.113090 PMC 바로가기
Effect of oral antiseptics in reducing SARS-CoV-2 infectivity: evidence from a randomized double-blind clinical trialRandomized Controlled Trial Published on 2022-12-012022-10-05 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 임상, [키워드] antiseptic mouthwashe cell cultures cetylpyridinium chloride clinical trial COVID-19 COVID-19 patients Culture double-blind Effect evaluated Evidence in vitro in vivo indicated Infectivity Mouthwash mouthwashe mouthwashes not affected Placebo placebo-controlled clinical trial quantitative PCR Randomized reduce reduced reducing Saliva salivary SARS-CoV-2 shown significantly tested viability viral infectivity Viral load Viral transmission virucidal [DOI] 10.1080/22221751.2022.2098059 PMC 바로가기 [Article Type] Randomized Controlled Trial
Naturally occurring spike mutations influence the infectivity and immunogenicity of SARS-CoV-2Article Published on 2022-11-012022-11-15 Journal: Cellular and Molecular Immunology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] A570D A701V addition Affect affected antibodies antigenicity B.1.1.529 B.1.1.7 B.1.1.7 lineage B.1.351 B.1.617.2 BALB/c mice binding circulating cross-neutralization activity D1118H decrease Del Delta determine DNA vaccine Effects Efficiency elicited humoral immune response immune evasion immunized immunogen in vitro investigated K417N L18F Lineage Mutation NAbs Naturally neutralization Neutralizing Neutralizing antibodies neutralizing antibody NTD omicron opposite overcome P681H Pseudotyped viruses reduced S982A SARS-CoV-2 SARS-CoV-2 variant sera significantly increased single mutation single mutations spike mutation T cell T cell responses T-cell Response T716I tested the RBD Transmissibility unlikely Vaccine vaccine immunogenicity variants of concern viral entry viral infectivity VoC VOCs was determined weakened [DOI] 10.1038/s41423-022-00924-8 PMC 바로가기
Dissecting Naturally Arising Amino Acid Substitutions at Position L452 of SARS-CoV-2 SpikeArticle Published on 2022-10-262022-11-15 Journal: Journal of Virology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acid acute respiratory syndrome addition addressed Amino acid amino acid substitution antigenic Antisera Care caused characterized coronavirus COVID-19 death demonstrated expressing expression level fitness FIVE GISAID globe greater Health highlight host immunity identifying Immune escape immune evasion immunological profile initiative Intervention L452 less lineages maintain mutant Mutation mutational studies Naturally neutralization pandemic phenotypic position promote pseudovirus retrieved SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variant selected sensitivity sequence single nucleotide spike Spike protein Substitution T cell Transmissibility variants of concern viral evolution viral fitness viral infectivity virus VoC [DOI] 10.1128/jvi.01162-22 PMC 바로가기
Murine Hepatitis Virus, a Biosafety Level 2 Model for SARS-CoV-2, Can Remain Viable on Meat and Meat Packaging Materials for at Least 48 HoursArticle Published on 2022-10-262022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 치료기술, [키워드] biosafety Biosafety Level 2 bottleneck BSL2 Can condition conditions contribute coronavirus Coronaviruses COVID-19 case creating detectable determine Evidence facilitate Factor FIVE highest hour hpi hygiene inoculated involved material meat MHV Model murine hepatitis virus notable outbreak packaging material. Particles persistence physical physical distancing plant provide reduction reduction in reservoir resulting SARS-CoV-2 Spread spread of COVID-19 steadily decreased Styrofoam survival tested unpaired t test viability Viable viral infectivity virus [DOI] 10.1128/spectrum.01862-22 PMC 바로가기
A human iPSC-array-based GWAS identifies a virus susceptibility locus in the NDUFA4 gene and functional variantsArticle Published on 2022-10-062022-11-16 Journal: Cell Stem Cell [Category] COVID19(2023년), SARS, 변종, [키워드] cause Cell Cluster Dengue dengue virus disease-associated functional variant genome-wide association Genome-wide association study GWAS Human genetics identify indicated individuals Infection iPSC array isogenic hiPSC lines leakage of mtDNA locus Loss mitochondrial mtDNA NDUFA4 non-risk allele polymorphism provide risk risk allele SARS-CoV-2 SARS-COV-2 infection screening strategy sensitivity Signaling single-nucleotide single-nucleotide polymorphism SNP SNPs Stress susceptibility type I interferon upregulation viral infection viral infectivity virus Zika virus ZIKV [DOI] 10.1016/j.stem.2022.09.008 PMC 바로가기