Dynamics of viral shedding during ancestral or Omicron BA.1 SARS-CoV-2 infection and enhancement of pre-existing immunity during breakthrough infectionsArticle Published on 2022-12-012022-11-15 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] addition Anti-RBD IgG antibody Breakthrough infection Cell cellular immunity cellular response circulating Delta Diagnosis Dynamics exhibited faster greater HCW HCWs healthcare worker humoral IFN-γ Immunity Infection infectiousness investigated isolates median neutralization capacity neutralizing antibody titre normalized omicron pandemic positive pre-existing immunity proportion reported RT-qPCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 isolates SARS-CoV-2 peptides SARS-CoV-2 variants symptom onset Vaccine vaccine-immunity variant viral clearance viral culture Viral load viral loads viral shedding Viral shedding. [DOI] 10.1080/22221751.2022.2122578 PMC 바로가기
An open, prospective cohort study of VV116 in Chinese participants infected with SARS-CoV-2 omicron variantsSARS-CoV-2 오미크론 변이체에 감염된 중국 참가자의 VV116에 대한 공개, 전향적 코호트 연구Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, [키워드] adjusted administration adverse event adverse events anti-SARS-CoV-2 antiviral drug baseline characteristics Chinese Cohort cohort study collected conducted control group COVID-19 Cox regression analysis effective Effectiveness Efficacy enrolled evaluate first positive Follow-up Hospitalized infected with SARS-CoV-2 Infection Intervention median time no significant difference omicron Omicron variant participant Patient preclinical studies predominant Prevalence prospective cohort study receive regression analysis reported resolved robust Safe Serious Adverse Event Serious Adverse Events standard treatment Symptom symptomatic treatment group variant variant of SARS-CoV-2 Viral load Viral load. viral shedding VV116 with COVID-19 [DOI] 10.1080/22221751.2022.2078230 PMC 바로가기 [Article Type] Article
Molecular detection of SARS-COV-2 in exhaled breath at the point-of-needArticle Published on 2022-12-012022-11-15 Journal: Biosensors & bioelectronics [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] Aerosols Analysis Antigen approach approach breath contagious contagiousness detect diagnostics Direct equipment help identify impactor Infection Lab-on-a-chip less limitation molecular Nasopharyngeal swab offer Particle Pathogens patients PCR positive quantification respiratory infections RT-qPCR Saliva SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2. Spread subject temporal dynamics tested Viral load Viral RNA viral shedding Volume while [DOI] 10.1016/j.bios.2022.114663 PMC 바로가기
Pulmonary lesions following inoculation with the SARS-CoV-2 Omicron BA.1 (B.1.1.529) variant in Syrian golden hamsters시리아 골든 햄스터에서 SARS-CoV-2 Omicron BA.1(B.1.1.529) 변종 접종 후 폐 병변Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, [키워드] animals B.1.1.529 B.1.617.2 characterized Clinical signs COVID-19 disease decrease Delta Disease progression disease severity evaluate Evidence evidence of golden hamster hamster hamsters histopathological Human Immune escape Immunity Infection inoculated intrinsic Kinetics lesion Mutation omicron Omicron BA.1 pathogenicity pathological changes pathology Pneumonia pre-existing immunity progression pulmonary re-challenge. reduced SARS-CoV-2 SARS-CoV-2 variant Syrian golden hamster the SARS-CoV-2 vaccination variant viral genome viral shedding viral spread virus [DOI] 10.1080/22221751.2022.2095932 PMC 바로가기 [Article Type] Article
Identification of CKD, bedridden history and cancer as higher-risk comorbidities and their impact on prognosis of hospitalized Omicron patients: a multi-centre cohort studyArticle Published on 2022-12-012022-11-16 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 치료기술, [키워드] advanced age age Cancer China Chronic kidney disease CKD cohort study Comorbidity condition conditions COVID-19 critical cases enrolled Factor female first positive hospialized population Hospitalized hospitalized patient hypertension identification Logistic regression Metabolic disorders multivariate Observational cohort study omicron participant Patient patients Primary outcome Prognosis progression risk factor Risk factors Risk factors. SARS-CoV-2 SARS-CoV-2 detection secondary outcome severity Shanghai suggested vaccination viral shedding [DOI] 10.1080/22221751.2022.2122581 PMC 바로가기
Omicron infections profile and vaccination status among 1881 liver transplant recipients: a multi-centre retrospective cohortArticle Published on 2022-12-012022-11-16 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome adverse event adverse events Breakthrough infection China clinical manifestation Cohort collected concerning conducted coronavirus Coronavirus disease 2019 COVID-19 COVID-19 vaccination decrease Efficacy enrolled fatigue feature grade 3 higher risk inactivated Inactivated vaccine Infection infections liver liver dysfunction Liver transplantation Mild myalgia occurred omicron participant Patient patients postoperative protection rate. recipient retrospective cohort Retrospective study Safe safety profile SARS-CoV-2 Seven vaccination Vaccine variant viral shedding were infected whole-virion SARS-CoV-2 vaccine [DOI] 10.1080/22221751.2022.2136535 PMC 바로가기
Onset and window of SARS-CoV-2 infectiousness and temporal correlation with symptom onset: a prospective, longitudinal, community cohort studyArticle Published on 2022-11-012022-11-15 Journal: The Lancet. Respiratory Medicine [Category] SARS, 변종, 치료기술, [키워드] accelerate Alpha assessment assumption Bayesian Cohort cohort study Community Contact correlation Course COVID-19 COVID-19 case determine diagnosed early diagnosis eight eligible enrolled Evidence Final Guidance Hierarchical High-resolution household index cases Infection infection control Infectious virus initial IQR Isolation kinetic Lateral flow device LFD median Older Onset participant PCR positive PCR-confirmed plaque-forming unit post-symptom onset Probability quantified real-world data recruitment reduced released RT-PCR SARS-CoV-2 Self-isolation sensitivity Seven study population suggested Support survival Symptom symptom onset Symptoms the median the SARS-CoV-2 to define Transmission upper respiratory tract variant viral growth Viral load viral replication Viral RNA viral RNA load viral shedding virus were assessed [DOI] 10.1016/S2213-2600(22)00226-0 PMC 바로가기
Transmission of SARS-CoV-2 by children to contacts in schools and households: a prospective cohort and environmental sampling study in LondonArticle Published on 2022-11-012022-11-16 Journal: The Lancet. Microbe [Category] SARS, 변종, 치료기술, [키워드] acquisition Assessing Asymptomatic children Community Contact Contamination Department eight Evidence FIVE Frequency Genome sequencing Health household contact household contacts IMPROVE incident index case Infection Innovation Laboratory Local London occur PCR testing positive positive PCR positive SARS-CoV-2 PCR Precaution Prevent prospective cohort public health pupil Pupils quantified reduced representing rising SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA SARS-CoV-2 transmission School Schools secondary transmission Spread supported symptomatic individual tested Testing throat swab Transmission transmission of SARS-CoV-2 variant Ventilation viral shedding was done Weekly with COVID-19 [DOI] 10.1016/S2666-5247(22)00124-0 PMC 바로가기
B.1.351 SARS-CoV-2 Variant Exhibits Higher Virulence but Less Viral Shedding than That of the Ancestral Strain in Young Nonhuman PrimatesArticle Published on 2022-10-262022-11-16 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] addition Alpha animal model association B.1.351 Beta caused changes in Characteristics Chinese circulating Clinical signs contribute determine distribution drugs early stage Efficacy and safety elevated exhibited IFN-γ IL-17 Infection Inflammatory Inflammatory cytokine interferon gamma interleukin 17 investigated less Lower respiratory tract lung tissue mechanisms mutated Necrosis NHP NHPs nonhuman primate pathogenesis of SARS-CoV-2 pathogenic pathogenicity pathological changes primate provide pulmonary inflammation reduced replicated Research rhesus macaque SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 vaccine SARS-CoV-2 variant SARS-CoV-2 variants severe lung injury shedding spike-specific T-cell response strain Strains tissue TNF-α Transmission upper respiratory tract Vaccine variant variants of concern viral distribution viral shedding virulence virulence. virulent VoC VOCs were infected [DOI] 10.1128/spectrum.02263-22 PMC 바로가기
Protection from COVID-19 with a VSV-based vaccine expressing the spike and nucleocapsid proteinsArticle Published on 2022-10-242022-11-16 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome addition Administered caused conserved coronavirus COVID-19 COVID-19 pandemic disease Efficacy effort expressing Hamster model highlighting intranasal intranasal vaccination memory morbidity and mortality nucleocapsid nucleocapsid protein pandemic PROTECT protection Protective Protein reduce reduced resulting SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 single dose the N protein the SARS-CoV-2 vaccination Vaccine variants of concern vesicular stomatitis virus Vesicular stomatitis virus. Viral antigen viral shedding VoC with COVID-19 [DOI] 10.3389/fimmu.2022.1025500 PMC 바로가기